ZN507_MOUSE
ID ZN507_MOUSE Reviewed; 941 AA.
AC Q6ZPY5; Q3UQU3; Q80VK1;
DT 02-SEP-2008, integrated into UniProtKB/Swiss-Prot.
DT 02-SEP-2008, sequence version 2.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Zinc finger protein 507;
GN Name=Znf507; Synonyms=Kiaa1084, Zfp507;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryonic tail;
RX PubMed=14621295; DOI=10.1093/dnares/10.4.167;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: III.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 10:167-180(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=129/Sv X 129SvCp; TISSUE=Embryonic stem cell;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-449.
RC STRAIN=C57BL/6J; TISSUE=Eye;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC98093.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK129283; BAC98093.1; ALT_INIT; mRNA.
DR EMBL; BC050041; AAH50041.1; -; mRNA.
DR EMBL; AK142141; BAE24946.1; -; mRNA.
DR CCDS; CCDS52204.1; -.
DR RefSeq; NP_808407.2; NM_177739.3.
DR RefSeq; XP_006540360.1; XM_006540297.2.
DR AlphaFoldDB; Q6ZPY5; -.
DR STRING; 10090.ENSMUSP00000058609; -.
DR iPTMnet; Q6ZPY5; -.
DR PhosphoSitePlus; Q6ZPY5; -.
DR EPD; Q6ZPY5; -.
DR MaxQB; Q6ZPY5; -.
DR PaxDb; Q6ZPY5; -.
DR PRIDE; Q6ZPY5; -.
DR ProteomicsDB; 302084; -.
DR Antibodypedia; 28867; 39 antibodies from 13 providers.
DR Ensembl; ENSMUST00000061586; ENSMUSP00000058609; ENSMUSG00000044452.
DR GeneID; 668501; -.
DR KEGG; mmu:668501; -.
DR UCSC; uc009gkh.3; mouse.
DR CTD; 668501; -.
DR MGI; MGI:1916378; Zfp507.
DR VEuPathDB; HostDB:ENSMUSG00000044452; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00490000043434; -.
DR HOGENOM; CLU_013272_0_0_1; -.
DR InParanoid; Q6ZPY5; -.
DR OMA; PICEHKA; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6ZPY5; -.
DR TreeFam; TF331496; -.
DR BioGRID-ORCS; 668501; 3 hits in 72 CRISPR screens.
DR ChiTaRS; Zfp507; mouse.
DR PRO; PR:Q6ZPY5; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6ZPY5; protein.
DR Bgee; ENSMUSG00000044452; Expressed in manus and 222 other tissues.
DR ExpressionAtlas; Q6ZPY5; baseline and differential.
DR Genevisible; Q6ZPY5; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 5.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..941
FT /note="Zinc finger protein 507"
FT /id="PRO_0000349309"
FT ZN_FING 122..144
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 152..175
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 237..259
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 630..652
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 658..680
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 686..709
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 746..768
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 774..796
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 899..921
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 165..198
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 455..477
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 823..856
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 174..195
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 832..856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 95
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TCN5"
FT MOD_RES 415
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8TCN5"
FT CONFLICT 185
FT /note="S -> Y (in Ref. 1; BAC98093)"
FT /evidence="ECO:0000305"
FT CONFLICT 857..858
FT /note="QL -> RQ (in Ref. 2; AAH50041)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 941 AA; 102884 MW; F38C864D9268A775 CRC64;
MEESSSIAML VQEIGEPEAV LTAEGVLSPS SEVDQQRKAK ADPLVHVIQK LSKIVGHEKS
QKCLLIGKKR PRPSETANSL EKLENCEIPA KATESPAAGV RKTEMSQASS TLASNDGKAM
SYQCSLCKFL SPSFSVLKEH VKQHGQQHDV MLMCSECHAT SRSQQELEAH VVSEHENSAS
SQARSSPSGQ GATERKSETM VDIPVNMGSP QTHAVQSAAM AESGRRKWYA YEQYGMYRCL
FCSYTCGQQR MLKTHAWKHA GEVNCSYPIF ENENEPLGLL ASSMSAAPGG VDAVVIAIGD
SELSIHNGPS VQVQICSSDP PSSSPLEQST EEGVHLNQAV TLDANEEEML EVMSDSEENL
FADSLLSSAQ KIISSSPNKK GHVNVIVERL PSAEETLPPK HFLINAEMEE GKSPSPSEAQ
TGCVGAGNMY HADKCTVDIG GLIIGWSSAE KKDSELSKGL APDENAPPGR RRTNSESLRL
HSLAAEALVT MPIRAAELTR ASLGHYGDIN LLDPDTGQRQ VSGPLATYSK KIMSPLKNST
DGVTSFNQSN STVVALPEGR QELSDGQVKT GISMSLLTVI EKLRERTDQN ASDDDILKEL
QDNAQCQPNS DGSLLGSNVV EYIPDAERPY RCRLCNYSSG NRGYIKQHLR VHRQRQPYQC
PICEHIAENS KDLESHMINH CKTRIHQCKQ CKESFHYKSQ LRNHEREQHC LPNTLSVASN
EPRISRDAAD GKCAQEGNKP STQKQYRCDV CDYTSTTYVG VRNHRRVHNS DKPYRCSLCG
YVCSHPPSLK SHMWKHASDQ NYNYEQVNKA INDAISQSAR VLGKSRGKPL LTSSEERTGP
TTGSPENLVS SSELTSQLPG EVMDASELEK LNPTGCSSDV SGRSCSLAAP GTEYCVLLFC
CCICGFESTS KESLLDHMKE HEGEIVSIIL NKDHSTALNA N
