ZN510_HUMAN
ID ZN510_HUMAN Reviewed; 683 AA.
AC Q9Y2H8; Q5SZP5;
DT 16-APR-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 182.
DE RecName: Full=Zinc finger protein 510;
GN Name=ZNF510; Synonyms=KIAA0972;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=10231032; DOI=10.1093/dnares/6.1.63;
RA Nagase T., Ishikawa K., Suyama M., Kikuno R., Hirosawa M., Miyajima N.,
RA Tanaka A., Kotani H., Nomura N., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XIII. The
RT complete sequences of 100 new cDNA clones from brain which code for large
RT proteins in vitro.";
RL DNA Res. 6:63-70(1999).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164053; DOI=10.1038/nature02465;
RA Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L.,
RA Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R.,
RA Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S.,
RA Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K.,
RA Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C.,
RA Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E.,
RA Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M.,
RA Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J.,
RA Frankish A., Frankland J.A., French L., Fricker D.G., Garner P.,
RA Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S.,
RA Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E.,
RA Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D.,
RA Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E.,
RA Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K.,
RA Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S.,
RA Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J.,
RA Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E.,
RA McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V.,
RA Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S.,
RA Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K.,
RA Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J.,
RA Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M.,
RA West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L.,
RA Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M.,
RA Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J.,
RA Dunham I.;
RT "DNA sequence and analysis of human chromosome 9.";
RL Nature 429:369-374(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-467.
RC TISSUE=Prostate;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA76816.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB023189; BAA76816.2; ALT_INIT; mRNA.
DR EMBL; AK292600; BAF85289.1; -; mRNA.
DR EMBL; AL589843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471174; EAW92666.1; -; Genomic_DNA.
DR EMBL; BC058022; AAH58022.1; ALT_TERM; mRNA.
DR CCDS; CCDS35074.1; -.
DR RefSeq; NP_001300988.1; NM_001314059.1.
DR RefSeq; NP_055745.1; NM_014930.2.
DR RefSeq; XP_016869972.1; XM_017014483.1.
DR AlphaFoldDB; Q9Y2H8; -.
DR SMR; Q9Y2H8; -.
DR BioGRID; 116536; 23.
DR IntAct; Q9Y2H8; 23.
DR MINT; Q9Y2H8; -.
DR STRING; 9606.ENSP00000364379; -.
DR iPTMnet; Q9Y2H8; -.
DR PhosphoSitePlus; Q9Y2H8; -.
DR BioMuta; ZNF510; -.
DR DMDM; 20178235; -.
DR jPOST; Q9Y2H8; -.
DR MassIVE; Q9Y2H8; -.
DR MaxQB; Q9Y2H8; -.
DR PaxDb; Q9Y2H8; -.
DR PeptideAtlas; Q9Y2H8; -.
DR PRIDE; Q9Y2H8; -.
DR ProteomicsDB; 85787; -.
DR Antibodypedia; 55571; 81 antibodies from 15 providers.
DR DNASU; 22869; -.
DR Ensembl; ENST00000223428.9; ENSP00000223428.4; ENSG00000081386.13.
DR Ensembl; ENST00000375231.5; ENSP00000364379.1; ENSG00000081386.13.
DR GeneID; 22869; -.
DR KEGG; hsa:22869; -.
DR MANE-Select; ENST00000223428.9; ENSP00000223428.4; NM_014930.3; NP_055745.1.
DR UCSC; uc004awn.1; human.
DR CTD; 22869; -.
DR GeneCards; ZNF510; -.
DR HGNC; HGNC:29161; ZNF510.
DR HPA; ENSG00000081386; Low tissue specificity.
DR MIM; 619385; gene.
DR neXtProt; NX_Q9Y2H8; -.
DR OpenTargets; ENSG00000081386; -.
DR PharmGKB; PA134944603; -.
DR VEuPathDB; HostDB:ENSG00000081386; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153505; -.
DR HOGENOM; CLU_002678_0_12_1; -.
DR InParanoid; Q9Y2H8; -.
DR OMA; CIFKPEV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9Y2H8; -.
DR TreeFam; TF337898; -.
DR PathwayCommons; Q9Y2H8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9Y2H8; -.
DR BioGRID-ORCS; 22869; 17 hits in 1104 CRISPR screens.
DR ChiTaRS; ZNF510; human.
DR GenomeRNAi; 22869; -.
DR Pharos; Q9Y2H8; Tdark.
DR PRO; PR:Q9Y2H8; -.
DR Proteomes; UP000005640; Chromosome 9.
DR RNAct; Q9Y2H8; protein.
DR Bgee; ENSG00000081386; Expressed in ganglionic eminence and 136 other tissues.
DR Genevisible; Q9Y2H8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..683
FT /note="Zinc finger protein 510"
FT /id="PRO_0000047628"
FT DOMAIN 46..117
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 254..276
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 460..482
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..566
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 572..594
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..622
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 628..650
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 43
FT /note="Q -> R (in dbSNP:rs2289651)"
FT /id="VAR_019982"
FT VARIANT 89
FT /note="C -> R (in dbSNP:rs3780548)"
FT /id="VAR_021893"
FT VARIANT 273
FT /note="N -> K (in dbSNP:rs10217154)"
FT /id="VAR_052848"
FT VARIANT 398
FT /note="H -> D (in dbSNP:rs11999094)"
FT /id="VAR_052849"
FT VARIANT 401
FT /note="M -> I (in dbSNP:rs10217494)"
FT /id="VAR_052850"
FT VARIANT 634
FT /note="G -> E (in dbSNP:rs10119874)"
FT /id="VAR_052851"
SQ SEQUENCE 683 AA; 79142 MW; A87DB365993EE3F3 CRC64;
MSPHPEAITD CVTLNTVGQL AEGGYPLRFS TLFQEQQKMN ISQASVSFKD VTIEFTQEEW
QQMAPVQKNL YRDVMLENYS NLVSVGYCCF KPEVIFKLEQ GEEPWFSEEE FSNQSHPKDY
RGDDLIKQNK KIKDKHLEQA ICINNKTLTT EEEKVLGKPF TLHVAAVAST KMSCKCNSWE
VNLQSISEFI INNRNYSTKK IGCGNVCENS PFKINFEKTQ TGEKFYEHNK NMKALNYNEN
LPKHPKFQTL EQAFECNKIG KAFNDKANCV KHNSSHTGET SSKDDEFRKN CDKKTLFDHR
RTGTGKKHLH LNQCGKSFEK STVEEYNKLN MGIKHYELNP SGNNFNRKAH LTDPQTAVIE
ENPLVSNDRT QTWVKSSEYH ENKKSYQTSV HRVRRRSHSM MKPYKCNECG KSFCQKGHLI
QHQRTHTGEK PFECSECGKT FSQKSHLSTH QRIHTAEKPY KCNECGKTFV QKSTLRGHQR
IHTGEKPYEC SECGKTFVQK STLRDHHRIH TGEKSFQCNQ CGKTFGQKSN LRIHQRTHTG
EKTYQCNECE KSFWRKDHLI QHQKTHTGEK PFKCNECGKT FARTSTLRVH QRIHTGEKPF
KCNECGKKFV RKAILSDHQR IHTGEKPFQC NKCGKTFGQK SNLRIHQRTH SGEKSYECNE
YGKLCKKSTL SLYQKIQGEG NPY
