ZN511_HUMAN
ID ZN511_HUMAN Reviewed; 252 AA.
AC Q8NB15; A8K8L5; Q8WUP1; Q96BV2;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 16-JAN-2019, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 511 {ECO:0000305};
GN Name=ZNF511 {ECO:0000312|HGNC:HGNC:28445};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Chondrocyte, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15164054; DOI=10.1038/nature02462;
RA Deloukas P., Earthrowl M.E., Grafham D.V., Rubenfield M., French L.,
RA Steward C.A., Sims S.K., Jones M.C., Searle S., Scott C., Howe K.,
RA Hunt S.E., Andrews T.D., Gilbert J.G.R., Swarbreck D., Ashurst J.L.,
RA Taylor A., Battles J., Bird C.P., Ainscough R., Almeida J.P.,
RA Ashwell R.I.S., Ambrose K.D., Babbage A.K., Bagguley C.L., Bailey J.,
RA Banerjee R., Bates K., Beasley H., Bray-Allen S., Brown A.J., Brown J.Y.,
RA Burford D.C., Burrill W., Burton J., Cahill P., Camire D., Carter N.P.,
RA Chapman J.C., Clark S.Y., Clarke G., Clee C.M., Clegg S., Corby N.,
RA Coulson A., Dhami P., Dutta I., Dunn M., Faulkner L., Frankish A.,
RA Frankland J.A., Garner P., Garnett J., Gribble S., Griffiths C.,
RA Grocock R., Gustafson E., Hammond S., Harley J.L., Hart E., Heath P.D.,
RA Ho T.P., Hopkins B., Horne J., Howden P.J., Huckle E., Hynds C.,
RA Johnson C., Johnson D., Kana A., Kay M., Kimberley A.M., Kershaw J.K.,
RA Kokkinaki M., Laird G.K., Lawlor S., Lee H.M., Leongamornlert D.A.,
RA Laird G., Lloyd C., Lloyd D.M., Loveland J., Lovell J., McLaren S.,
RA McLay K.E., McMurray A., Mashreghi-Mohammadi M., Matthews L., Milne S.,
RA Nickerson T., Nguyen M., Overton-Larty E., Palmer S.A., Pearce A.V.,
RA Peck A.I., Pelan S., Phillimore B., Porter K., Rice C.M., Rogosin A.,
RA Ross M.T., Sarafidou T., Sehra H.K., Shownkeen R., Skuce C.D., Smith M.,
RA Standring L., Sycamore N., Tester J., Thorpe A., Torcasso W., Tracey A.,
RA Tromans A., Tsolas J., Wall M., Walsh J., Wang H., Weinstock K., West A.P.,
RA Willey D.L., Whitehead S.L., Wilming L., Wray P.W., Young L., Chen Y.,
RA Lovering R.C., Moschonas N.K., Siebert R., Fechtel K., Bentley D.,
RA Durbin R.M., Hubbard T., Doucette-Stamm L., Beck S., Smith D.R., Rogers J.;
RT "The DNA sequence and comparative analysis of human chromosome 10.";
RL Nature 429:375-381(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Brain, and Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-240 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Colon carcinoma;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000305}.
CC -!- INTERACTION:
CC Q8NB15; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-10269136, EBI-12006120;
CC Q8NB15; Q8IYR0: CFAP206; NbExp=3; IntAct=EBI-10269136, EBI-749051;
CC Q8NB15; P51800-3: CLCNKA; NbExp=3; IntAct=EBI-10269136, EBI-11980535;
CC Q8NB15; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-10269136, EBI-744099;
CC Q8NB15; O75031: HSF2BP; NbExp=3; IntAct=EBI-10269136, EBI-7116203;
CC Q8NB15; P61371: ISL1; NbExp=7; IntAct=EBI-10269136, EBI-3906896;
CC Q8NB15; Q92993: KAT5; NbExp=3; IntAct=EBI-10269136, EBI-399080;
CC Q8NB15; P50458: LHX2; NbExp=3; IntAct=EBI-10269136, EBI-12179869;
CC Q8NB15; P25800: LMO1; NbExp=6; IntAct=EBI-10269136, EBI-8639312;
CC Q8NB15; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-10269136, EBI-77889;
CC Q8NB15; Q96HA8: NTAQ1; NbExp=3; IntAct=EBI-10269136, EBI-741158;
CC Q8NB15; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-10269136, EBI-748391;
CC Q8NB15; Q96GM5: SMARCD1; NbExp=3; IntAct=EBI-10269136, EBI-358489;
CC Q8NB15; Q96DC7: TMCO6; NbExp=6; IntAct=EBI-10269136, EBI-746174;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=2;
CC IsoId=Q8NB15-2; Sequence=Displayed;
CC Name=1;
CC IsoId=Q8NB15-1; Sequence=VSP_059997;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH15139.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK091711; BAC03729.1; -; mRNA.
DR EMBL; AK292380; BAF85069.1; -; mRNA.
DR EMBL; AL360181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471211; EAW61333.1; -; Genomic_DNA.
DR EMBL; BC015139; AAH15139.1; ALT_INIT; mRNA.
DR EMBL; BC019897; AAH19897.1; -; mRNA.
DR CCDS; CCDS7677.1; -. [Q8NB15-2]
DR RefSeq; NP_665805.2; NM_145806.3. [Q8NB15-2]
DR AlphaFoldDB; Q8NB15; -.
DR BioGRID; 125611; 40.
DR IntAct; Q8NB15; 26.
DR STRING; 9606.ENSP00000355251; -.
DR iPTMnet; Q8NB15; -.
DR PhosphoSitePlus; Q8NB15; -.
DR BioMuta; ZNF511; -.
DR DMDM; 74760090; -.
DR EPD; Q8NB15; -.
DR jPOST; Q8NB15; -.
DR MassIVE; Q8NB15; -.
DR MaxQB; Q8NB15; -.
DR PaxDb; Q8NB15; -.
DR PeptideAtlas; Q8NB15; -.
DR PRIDE; Q8NB15; -.
DR ProteomicsDB; 72716; -. [Q8NB15-1]
DR ProteomicsDB; 72717; -. [Q8NB15-2]
DR Antibodypedia; 32647; 65 antibodies from 16 providers.
DR DNASU; 118472; -.
DR Ensembl; ENST00000359035.4; ENSP00000351929.3; ENSG00000198546.15. [Q8NB15-1]
DR Ensembl; ENST00000361518.10; ENSP00000355251.5; ENSG00000198546.15. [Q8NB15-2]
DR GeneID; 118472; -.
DR KEGG; hsa:118472; -.
DR MANE-Select; ENST00000361518.10; ENSP00000355251.5; NM_145806.4; NP_665805.2.
DR UCSC; uc001lmj.2; human. [Q8NB15-2]
DR CTD; 118472; -.
DR GeneCards; ZNF511; -.
DR HGNC; HGNC:28445; ZNF511.
DR HPA; ENSG00000198546; Low tissue specificity.
DR neXtProt; NX_Q8NB15; -.
DR OpenTargets; ENSG00000198546; -.
DR PharmGKB; PA134940031; -.
DR VEuPathDB; HostDB:ENSG00000198546; -.
DR eggNOG; KOG4173; Eukaryota.
DR GeneTree; ENSGT00390000011381; -.
DR HOGENOM; CLU_092647_0_0_1; -.
DR InParanoid; Q8NB15; -.
DR OMA; CHISGCR; -.
DR OrthoDB; 1360267at2759; -.
DR PhylomeDB; Q8NB15; -.
DR TreeFam; TF323277; -.
DR PathwayCommons; Q8NB15; -.
DR SignaLink; Q8NB15; -.
DR BioGRID-ORCS; 118472; 108 hits in 1084 CRISPR screens.
DR ChiTaRS; ZNF511; human.
DR GenomeRNAi; 118472; -.
DR Pharos; Q8NB15; Tdark.
DR PRO; PR:Q8NB15; -.
DR Proteomes; UP000005640; Chromosome 10.
DR RNAct; Q8NB15; protein.
DR Bgee; ENSG00000198546; Expressed in hindlimb stylopod muscle and 181 other tissues.
DR Genevisible; Q8NB15; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR039258; ZNF511.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR21354; PTHR21354; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Methylation; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..252
FT /note="Zinc finger protein 511"
FT /id="PRO_0000047629"
FT ZN_FING 80..105
FT /note="C2H2-type 1"
FT ZN_FING 107..130
FT /note="C2H2-type 2"
FT ZN_FING 144..169
FT /note="C2H2-type 3"
FT REGION 177..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 240
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT VAR_SEQ 228..252
FT /note="IPSTICFGQGAARGFKSNKKKTKQC -> SVSELFLKPVLNMCSVLRILGCT
FT WAAALLILNSER (in isoform 1)"
FT /id="VSP_059997"
SQ SEQUENCE 252 AA; 28265 MW; 06EB73C722D8BA33 CRC64;
MQLPPALCAR LAAGPGAAEP LPVERDPAAG AAPFRFVARP VRFPREHQFF EDGDVQRHLY
LQDVIMQVAD VPEKPRVPAF ACQVAGCCQV FDALDDYEHH YHTLHGNVCS FCKRAFPSGH
LLDAHILEWH DSLFQILSER QDMYQCLVEG CTEKFKTSRD RKDHMVRMHL YPADFRFDKP
KKSRSPASAE APGDSGERSE GEAMEICSEP VAASPAPAGE RRIYRHRIPS TICFGQGAAR
GFKSNKKKTK QC
