ZN511_MOUSE
ID ZN511_MOUSE Reviewed; 227 AA.
AC Q6P0X2;
DT 04-NOV-2008, integrated into UniProtKB/Swiss-Prot.
DT 04-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 104.
DE RecName: Full=Zinc finger protein 511;
GN Name=Znf511; Synonyms=Zfp511;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=C57BL/6J; TISSUE=Thymus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-238 (ISOFORM 2), AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6P0X2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6P0X2-2; Sequence=VSP_035623;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC109205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC065404; AAH65404.1; -; mRNA.
DR CCDS; CCDS52431.1; -. [Q6P0X2-2]
DR RefSeq; NP_081477.1; NM_027201.1. [Q6P0X2-2]
DR AlphaFoldDB; Q6P0X2; -.
DR STRING; 10090.ENSMUSP00000129154; -.
DR iPTMnet; Q6P0X2; -.
DR PhosphoSitePlus; Q6P0X2; -.
DR EPD; Q6P0X2; -.
DR MaxQB; Q6P0X2; -.
DR PaxDb; Q6P0X2; -.
DR PeptideAtlas; Q6P0X2; -.
DR PRIDE; Q6P0X2; -.
DR ProteomicsDB; 299583; -. [Q6P0X2-2]
DR Antibodypedia; 32647; 65 antibodies from 16 providers.
DR Ensembl; ENSMUST00000168194; ENSMUSP00000129154; ENSMUSG00000025470. [Q6P0X2-2]
DR GeneID; 69752; -.
DR KEGG; mmu:69752; -.
DR UCSC; uc012fwe.1; mouse. [Q6P0X2-2]
DR CTD; 69752; -.
DR MGI; MGI:1917002; Zfp511.
DR VEuPathDB; HostDB:ENSMUSG00000025470; -.
DR eggNOG; KOG4173; Eukaryota.
DR GeneTree; ENSGT00390000011381; -.
DR HOGENOM; CLU_092647_0_0_1; -.
DR InParanoid; Q6P0X2; -.
DR OMA; CHISGCR; -.
DR OrthoDB; 1360267at2759; -.
DR PhylomeDB; Q6P0X2; -.
DR TreeFam; TF323277; -.
DR BioGRID-ORCS; 69752; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q6P0X2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q6P0X2; protein.
DR Bgee; ENSMUSG00000025470; Expressed in embryonic brain and 227 other tissues.
DR ExpressionAtlas; Q6P0X2; baseline and differential.
DR Genevisible; Q6P0X2; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR039258; ZNF511.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR21354; PTHR21354; 1.
DR SMART; SM00355; ZnF_C2H2; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Methylation; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..227
FT /note="Zinc finger protein 511"
FT /id="PRO_0000353091"
FT ZN_FING 80..105
FT /note="C2H2-type 1"
FT ZN_FING 107..130
FT /note="C2H2-type 2"
FT ZN_FING 144..169
FT /note="C2H2-type 3"
FT REGION 180..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 226..227
FT /note="SV -> IPSTVCFGQGAARGFKSTKKKNKHH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_035623"
FT MOD_RES Q6P0X2-2:238
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
SQ SEQUENCE 227 AA; 25761 MW; 7FCA52DF931D5DA7 CRC64;
MLLPPALYSR LAGEPGAAEP LPVERNPAAG EAPFRFAPRA VRFPRDHEFF EDGDVQRHLY
LQDMLTQVSE TPEKSMVPEF TCQVAGCCQV FAAIEDYQHH YHMMHGNTCS FCNRAFPSGH
LLDVHILEWH DSLFQILAQR QDMYQCLVES CPEKFKTSQD RKDHMVRLHL YPADFRFDKP
KTNRGPAMPA AADAATRAPT DDSDAMEICS EPAAPPPCRR TYSHRSV
