ID   ZN512_PONAB             Reviewed;         567 AA.
AC   Q5R6F3; Q5R5Q5;
DT   12-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   21-DEC-2004, sequence version 1.
DT   03-AUG-2022, entry version 99.
DE   RecName: Full=Zinc finger protein 512;
GN   Name=ZNF512;
OS   Pongo abelii (Sumatran orangutan) (Pongo pygmaeus abelii).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9601;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain cortex;
RG   The German cDNA consortium;
RL   Submitted (NOV-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; CR860537; CAH92663.1; -; mRNA.
DR   EMBL; CR860801; CAH92911.1; -; mRNA.
DR   RefSeq; NP_001126711.1; NM_001133239.1.
DR   RefSeq; NP_001128873.1; NM_001135401.1.
DR   AlphaFoldDB; Q5R6F3; -.
DR   STRING; 9601.ENSPPYP00000014005; -.
DR   Ensembl; ENSPPYT00000014572; ENSPPYP00000014005; ENSPPYG00000012540.
DR   GeneID; 100173711; -.
DR   KEGG; pon:100173711; -.
DR   CTD; 84450; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000158595; -.
DR   HOGENOM; CLU_481412_0_0_1; -.
DR   InParanoid; Q5R6F3; -.
DR   OMA; PFFPESG; -.
DR   OrthoDB; 222563at2759; -.
DR   TreeFam; TF331185; -.
DR   Proteomes; UP000001595; Chromosome 2A.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF00096; zf-C2H2; 1.
DR   SMART; SM00355; ZnF_C2H2; 4.
DR   SUPFAM; SSF57667; SSF57667; 5.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 3.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW   Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW   Zinc-finger.
FT   CHAIN           1..567
FT                   /note="Zinc finger protein 512"
FT                   /id="PRO_0000290350"
FT   ZN_FING         197..220
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         287..310
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         406..430
FT                   /note="C2H2-type 3; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         440..463
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..32
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          86..148
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          486..567
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        97..119
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CROSSLNK        18
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96ME7"
FT   CROSSLNK        84
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96ME7"
FT   CROSSLNK        227
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96ME7"
FT   CROSSLNK        333
FT                   /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT                   G-Cter in SUMO2)"
FT                   /evidence="ECO:0000250|UniProtKB:Q96ME7"
FT   CONFLICT        4
FT                   /note="R -> S (in Ref. 1; CAH92911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        13
FT                   /note="G -> R (in Ref. 1; CAH92911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        31
FT                   /note="Missing (in Ref. 1; CAH92911)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        167
FT                   /note="G -> D (in Ref. 1; CAH92911)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   567 AA;  64652 MW;  129D4371E3B47F64 CRC64;
     MSSRLGAVPA TSGPTTFKQQ RSTRIVGAKN SRTQCSIKDN SFQYTIPHDD SLSGSSSASS
     CEPVSDFPAS FRKSAYWMKM RRIKPAATSH VEGSGGVSAK GKRKPRQEED EDYREFPQKK
     HKLYGRKQRP KTQPNPKSQA RRIRKEPPVY AAGSLEEQWY LEIVDKGSVS CPTCQAVGRK
     TIEGLKKHME NCKQEMFTCH HCGKQLRSLA GMKYHVMANH NSLPILKAGD EIDEPSERER
     LRTVLKRLGK LRCMRESCSS SFTSIMGYLY HVRKCGKGAA ELEKMTLKCH HCGKPYRSKA
     GLAYHLRSEH GPISFFPESG QPECLKEMNL ESKSGGRVQR RSAKIAVYHL QELASAELAK
     EWPKRKVLQD LVPDDRKLKY TRPGLPTFSQ EVLHKWKTDI KKYHRIQCPN QGCEAVYSSV
     SGLKAHLGSC TLGNFVAGKY KCLLCQKEFV SESGVKYHIN SVHAEDWFVV NPTTTKSFEK
     LMKIKQRQQE EEKRRQQHRS RRSLRRRQQP GIELPETELS LRVGKDQRRN NEELVVSASC
     KEPEQEPVPA QFQKVKPPKT NHKRGRK