ZN514_HUMAN
ID ZN514_HUMAN Reviewed; 400 AA.
AC Q96K75; Q5JPJ3;
DT 16-FEB-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 514;
GN Name=ZNF514;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lymph node;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15815621; DOI=10.1038/nature03466;
RA Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P.,
RA Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C.,
RA Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L.,
RA Du H., Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A.,
RA Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J.,
RA Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M.,
RA Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T.,
RA Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S.,
RA Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K.,
RA McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C.,
RA Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S.,
RA Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C.,
RA Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M.,
RA Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C.,
RA Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J.,
RA Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E.,
RA Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X.,
RA Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M.,
RA Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C.,
RA Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S.,
RA Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H.,
RA Wilson R.K.;
RT "Generation and annotation of the DNA sequences of human chromosomes 2 and
RT 4.";
RL Nature 434:724-731(2005).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK027363; BAB55064.1; -; mRNA.
DR EMBL; AL832263; CAI46170.1; -; mRNA.
DR EMBL; AC092835; AAX88981.1; -; Genomic_DNA.
DR EMBL; BC074900; AAH74900.1; -; mRNA.
DR EMBL; BC074901; AAH74901.1; -; mRNA.
DR EMBL; BC110524; AAI10525.1; -; mRNA.
DR EMBL; BC110525; AAI10526.1; -; mRNA.
DR CCDS; CCDS2011.1; -.
DR RefSeq; NP_001304934.1; NM_001318005.1.
DR RefSeq; NP_116177.1; NM_032788.2.
DR RefSeq; XP_006712869.1; XM_006712806.2.
DR AlphaFoldDB; Q96K75; -.
DR SMR; Q96K75; -.
DR BioGRID; 124319; 21.
DR IntAct; Q96K75; 15.
DR MINT; Q96K75; -.
DR STRING; 9606.ENSP00000295208; -.
DR GlyGen; Q96K75; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96K75; -.
DR PhosphoSitePlus; Q96K75; -.
DR BioMuta; ZNF514; -.
DR DMDM; 42560003; -.
DR EPD; Q96K75; -.
DR MassIVE; Q96K75; -.
DR PaxDb; Q96K75; -.
DR PeptideAtlas; Q96K75; -.
DR PRIDE; Q96K75; -.
DR ProteomicsDB; 77046; -.
DR Antibodypedia; 32302; 111 antibodies from 16 providers.
DR DNASU; 84874; -.
DR Ensembl; ENST00000295208.7; ENSP00000295208.2; ENSG00000144026.12.
DR Ensembl; ENST00000411425.1; ENSP00000405509.1; ENSG00000144026.12.
DR GeneID; 84874; -.
DR KEGG; hsa:84874; -.
DR MANE-Select; ENST00000295208.7; ENSP00000295208.2; NM_032788.3; NP_116177.1.
DR UCSC; uc002sue.2; human.
DR CTD; 84874; -.
DR GeneCards; ZNF514; -.
DR HGNC; HGNC:25894; ZNF514.
DR HPA; ENSG00000144026; Low tissue specificity.
DR neXtProt; NX_Q96K75; -.
DR OpenTargets; ENSG00000144026; -.
DR PharmGKB; PA134978837; -.
DR VEuPathDB; HostDB:ENSG00000144026; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163499; -.
DR HOGENOM; CLU_002678_0_7_1; -.
DR InParanoid; Q96K75; -.
DR OMA; DHEWSEF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96K75; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q96K75; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96K75; -.
DR BioGRID-ORCS; 84874; 11 hits in 1101 CRISPR screens.
DR ChiTaRS; ZNF514; human.
DR GenomeRNAi; 84874; -.
DR Pharos; Q96K75; Tdark.
DR PRO; PR:Q96K75; -.
DR Proteomes; UP000005640; Chromosome 2.
DR RNAct; Q96K75; protein.
DR Bgee; ENSG00000144026; Expressed in endothelial cell and 181 other tissues.
DR ExpressionAtlas; Q96K75; baseline and differential.
DR Genevisible; Q96K75; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 7.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 7.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..400
FT /note="Zinc finger protein 514"
FT /id="PRO_0000047633"
FT DOMAIN 1..72
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 204..226
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 400 AA; 45938 MW; 7BD27F892ABE3FF8 CRC64;
MTFEDVAVEF SQWEWGQLNP AQKDLYREVM LENFRNLAIL GLLVSKPYVI CQLEEGGEPF
MVEREISTGA HSDWKRRSKS KESMPSWGIS KEELFQVVSV EKHIQDVLQF SKLKAACGCD
GQLEMQQIKQ ERHLKQMSTI HKSATTLSRD YKWNGFGRSL GLRSVLVNQH SILMGEGSYK
CDTEFRQTLG GNNSQRTHPE KKSCKCNECG KSFHFQSELR RHQRCHTGEK PYECSDCGRA
FGHISSLIKH QRTHTGEKPY ECSECGRAFS QSSSLVLHYR FHTGEKPYKC NECGRAFGHT
SSLIKHQRTH TGEKPYECRE CGRTFSQSSS LIVHYRFHTG EKPYKCNKCG RAFSQSSSLT
QHYRFHTGEK PYKCNECGRA FAHTASLIKH QRSHAGKKTL
