ZN519_HUMAN
ID ZN519_HUMAN Reviewed; 540 AA.
AC Q8TB69;
DT 24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 519;
GN Name=ZNF519;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=16177791; DOI=10.1038/nature03983;
RA Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT "DNA sequence and analysis of human chromosome 18.";
RL Nature 437:551-555(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-206.
RC TISSUE=Prostatic adenocarcinoma;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC006557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC024227; AAH24227.1; -; mRNA.
DR CCDS; CCDS32797.1; -.
DR RefSeq; NP_660330.2; NM_145287.3.
DR RefSeq; XP_016881051.1; XM_017025562.1.
DR RefSeq; XP_016881052.1; XM_017025563.1.
DR RefSeq; XP_016881053.1; XM_017025564.1.
DR RefSeq; XP_016881054.1; XM_017025565.1.
DR AlphaFoldDB; Q8TB69; -.
DR SMR; Q8TB69; -.
DR BioGRID; 127827; 1.
DR IntAct; Q8TB69; 1.
DR STRING; 9606.ENSP00000464872; -.
DR iPTMnet; Q8TB69; -.
DR PhosphoSitePlus; Q8TB69; -.
DR BioMuta; ZNF519; -.
DR DMDM; 296453045; -.
DR EPD; Q8TB69; -.
DR jPOST; Q8TB69; -.
DR MassIVE; Q8TB69; -.
DR PaxDb; Q8TB69; -.
DR PeptideAtlas; Q8TB69; -.
DR PRIDE; Q8TB69; -.
DR ProteomicsDB; 73968; -.
DR Antibodypedia; 21965; 27 antibodies from 12 providers.
DR DNASU; 162655; -.
DR Ensembl; ENST00000590202.3; ENSP00000464872.2; ENSG00000175322.12.
DR GeneID; 162655; -.
DR KEGG; hsa:162655; -.
DR MANE-Select; ENST00000590202.3; ENSP00000464872.2; NM_145287.4; NP_660330.2.
DR UCSC; uc002kst.3; human.
DR CTD; 162655; -.
DR GeneCards; ZNF519; -.
DR HGNC; HGNC:30574; ZNF519.
DR HPA; ENSG00000175322; Low tissue specificity.
DR neXtProt; NX_Q8TB69; -.
DR OpenTargets; ENSG00000175322; -.
DR PharmGKB; PA134863605; -.
DR VEuPathDB; HostDB:ENSG00000175322; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000153165; -.
DR HOGENOM; CLU_002678_44_17_1; -.
DR InParanoid; Q8TB69; -.
DR OMA; FNRGSYL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TB69; -.
DR PathwayCommons; Q8TB69; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TB69; -.
DR BioGRID-ORCS; 162655; 38 hits in 1035 CRISPR screens.
DR GenomeRNAi; 162655; -.
DR Pharos; Q8TB69; Tdark.
DR PRO; PR:Q8TB69; -.
DR Proteomes; UP000005640; Chromosome 18.
DR RNAct; Q8TB69; protein.
DR Bgee; ENSG00000175322; Expressed in buccal mucosa cell and 117 other tissues.
DR ExpressionAtlas; Q8TB69; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..540
FT /note="Zinc finger protein 519"
FT /id="PRO_0000047637"
FT DOMAIN 4..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 181..203
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 460..482
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 18
FT /note="W -> R (in dbSNP:rs16941623)"
FT /id="VAR_052854"
FT VARIANT 89
FT /note="G -> S (in dbSNP:rs10221432)"
FT /id="VAR_052855"
FT VARIANT 206
FT /note="K -> E (in dbSNP:rs2159940)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_052856"
FT VARIANT 229
FT /note="R -> I (in dbSNP:rs8094412)"
FT /id="VAR_052857"
FT CONFLICT 167
FT /note="N -> D (in Ref. 2; AAH24227)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 540 AA; 63020 MW; D3212C320B418C3C CRC64;
MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN QGILPEQGIQ
DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL CSQYLTTSHN KHLTVKGDKE
YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL KSVFCNKNQI NFNHDSNISK HHSTHFLENY
YNCNECEKVF YQSSKLIFPE NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN
KKCIIVFSQS HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA
FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC EECGKAFNRG
SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG EKPFKCKECG KAFNRASHLT
QHQRIHTGEK HFKCKECGKA FNRGSHLTRH QRIHTGEKSF KCEECGKAFI WGSHLTQHQR
VHTGEKFFKC KECGKAFTRS SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR