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ZN519_HUMAN
ID   ZN519_HUMAN             Reviewed;         540 AA.
AC   Q8TB69;
DT   24-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   18-MAY-2010, sequence version 2.
DT   03-AUG-2022, entry version 153.
DE   RecName: Full=Zinc finger protein 519;
GN   Name=ZNF519;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16177791; DOI=10.1038/nature03983;
RA   Nusbaum C., Zody M.C., Borowsky M.L., Kamal M., Kodira C.D., Taylor T.D.,
RA   Whittaker C.A., Chang J.L., Cuomo C.A., Dewar K., FitzGerald M.G., Yang X.,
RA   Abouelleil A., Allen N.R., Anderson S., Bloom T., Bugalter B., Butler J.,
RA   Cook A., DeCaprio D., Engels R., Garber M., Gnirke A., Hafez N., Hall J.L.,
RA   Norman C.H., Itoh T., Jaffe D.B., Kuroki Y., Lehoczky J., Lui A.,
RA   Macdonald P., Mauceli E., Mikkelsen T.S., Naylor J.W., Nicol R., Nguyen C.,
RA   Noguchi H., O'Leary S.B., Piqani B., Smith C.L., Talamas J.A., Topham K.,
RA   Totoki Y., Toyoda A., Wain H.M., Young S.K., Zeng Q., Zimmer A.R.,
RA   Fujiyama A., Hattori M., Birren B.W., Sakaki Y., Lander E.S.;
RT   "DNA sequence and analysis of human chromosome 18.";
RL   Nature 437:551-555(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT GLU-206.
RC   TISSUE=Prostatic adenocarcinoma;
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA project:
RT   the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
CC   -!- FUNCTION: May be involved in transcriptional regulation.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; AC006557; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BC024227; AAH24227.1; -; mRNA.
DR   CCDS; CCDS32797.1; -.
DR   RefSeq; NP_660330.2; NM_145287.3.
DR   RefSeq; XP_016881051.1; XM_017025562.1.
DR   RefSeq; XP_016881052.1; XM_017025563.1.
DR   RefSeq; XP_016881053.1; XM_017025564.1.
DR   RefSeq; XP_016881054.1; XM_017025565.1.
DR   AlphaFoldDB; Q8TB69; -.
DR   SMR; Q8TB69; -.
DR   BioGRID; 127827; 1.
DR   IntAct; Q8TB69; 1.
DR   STRING; 9606.ENSP00000464872; -.
DR   iPTMnet; Q8TB69; -.
DR   PhosphoSitePlus; Q8TB69; -.
DR   BioMuta; ZNF519; -.
DR   DMDM; 296453045; -.
DR   EPD; Q8TB69; -.
DR   jPOST; Q8TB69; -.
DR   MassIVE; Q8TB69; -.
DR   PaxDb; Q8TB69; -.
DR   PeptideAtlas; Q8TB69; -.
DR   PRIDE; Q8TB69; -.
DR   ProteomicsDB; 73968; -.
DR   Antibodypedia; 21965; 27 antibodies from 12 providers.
DR   DNASU; 162655; -.
DR   Ensembl; ENST00000590202.3; ENSP00000464872.2; ENSG00000175322.12.
DR   GeneID; 162655; -.
DR   KEGG; hsa:162655; -.
DR   MANE-Select; ENST00000590202.3; ENSP00000464872.2; NM_145287.4; NP_660330.2.
DR   UCSC; uc002kst.3; human.
DR   CTD; 162655; -.
DR   GeneCards; ZNF519; -.
DR   HGNC; HGNC:30574; ZNF519.
DR   HPA; ENSG00000175322; Low tissue specificity.
DR   neXtProt; NX_Q8TB69; -.
DR   OpenTargets; ENSG00000175322; -.
DR   PharmGKB; PA134863605; -.
DR   VEuPathDB; HostDB:ENSG00000175322; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   GeneTree; ENSGT00940000153165; -.
DR   HOGENOM; CLU_002678_44_17_1; -.
DR   InParanoid; Q8TB69; -.
DR   OMA; FNRGSYL; -.
DR   OrthoDB; 1318335at2759; -.
DR   PhylomeDB; Q8TB69; -.
DR   PathwayCommons; Q8TB69; -.
DR   Reactome; R-HSA-212436; Generic Transcription Pathway.
DR   SignaLink; Q8TB69; -.
DR   BioGRID-ORCS; 162655; 38 hits in 1035 CRISPR screens.
DR   GenomeRNAi; 162655; -.
DR   Pharos; Q8TB69; Tdark.
DR   PRO; PR:Q8TB69; -.
DR   Proteomes; UP000005640; Chromosome 18.
DR   RNAct; Q8TB69; protein.
DR   Bgee; ENSG00000175322; Expressed in buccal mucosa cell and 117 other tissues.
DR   ExpressionAtlas; Q8TB69; baseline and differential.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   CDD; cd07765; KRAB_A-box; 1.
DR   InterPro; IPR001909; KRAB.
DR   InterPro; IPR036051; KRAB_dom_sf.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01352; KRAB; 1.
DR   Pfam; PF00096; zf-C2H2; 9.
DR   SMART; SM00349; KRAB; 1.
DR   SMART; SM00355; ZnF_C2H2; 10.
DR   SUPFAM; SSF109640; SSF109640; 1.
DR   SUPFAM; SSF57667; SSF57667; 7.
DR   PROSITE; PS50805; KRAB; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE   2: Evidence at transcript level;
KW   DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW   Transcription; Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           1..540
FT                   /note="Zinc finger protein 519"
FT                   /id="PRO_0000047637"
FT   DOMAIN          4..78
FT                   /note="KRAB"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT   ZN_FING         181..203
FT                   /note="C2H2-type 1; degenerate"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         292..314
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         320..342
FT                   /note="C2H2-type 3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         348..370
FT                   /note="C2H2-type 4"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         376..398
FT                   /note="C2H2-type 5"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         404..426
FT                   /note="C2H2-type 6"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         432..454
FT                   /note="C2H2-type 7"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         460..482
FT                   /note="C2H2-type 8"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         488..510
FT                   /note="C2H2-type 9"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         516..538
FT                   /note="C2H2-type 10"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   VARIANT         18
FT                   /note="W -> R (in dbSNP:rs16941623)"
FT                   /id="VAR_052854"
FT   VARIANT         89
FT                   /note="G -> S (in dbSNP:rs10221432)"
FT                   /id="VAR_052855"
FT   VARIANT         206
FT                   /note="K -> E (in dbSNP:rs2159940)"
FT                   /evidence="ECO:0000269|PubMed:15489334"
FT                   /id="VAR_052856"
FT   VARIANT         229
FT                   /note="R -> I (in dbSNP:rs8094412)"
FT                   /id="VAR_052857"
FT   CONFLICT        167
FT                   /note="N -> D (in Ref. 2; AAH24227)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   540 AA;  63020 MW;  D3212C320B418C3C CRC64;
     MELLTFRDVA IEFSPEEWKC LDPAQQNLYR DVMLENYRNL VSLAVYSYYN QGILPEQGIQ
     DSFKKATLGR YGSCGLENIC LWKNWESIGE GEGQKECYNL CSQYLTTSHN KHLTVKGDKE
     YRIFQKKPQF LSAAPTEPCI PMNKYQHKFL KSVFCNKNQI NFNHDSNISK HHSTHFLENY
     YNCNECEKVF YQSSKLIFPE NIHIQKKPYN SNECGETSDP FSKLTQHQRI YIGESSQRCN
     KKCIIVFSQS HLKGHKIINT GEKSVKYKER GKAFTRGLHL GHQKIHTGEK PYKCKKCDKA
     FNKSSHLAQH QRIHTGEKPF KCKECGKAFN RGSYLTQHQR IHTGERAFKC EECGKAFNRG
     SYLTQHQRIH TGEKPFRCKE CGKAFNRSSY VTQHQRMHTG EKPFKCKECG KAFNRASHLT
     QHQRIHTGEK HFKCKECGKA FNRGSHLTRH QRIHTGEKSF KCEECGKAFI WGSHLTQHQR
     VHTGEKFFKC KECGKAFTRS SHLTQHQRIH TGEKPFKCKE CGKAFNRRST LTQHQIIHTR
 
 
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