ZN524_MOUSE
ID ZN524_MOUSE Reviewed; 321 AA.
AC Q9D0B1; Q9DCQ0;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 161.
DE RecName: Full=Zinc finger protein 524;
GN Name=Znf524; Synonyms=Zfp524;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, Embryo, and Kidney;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=FVB/N; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB22215.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK002594; BAB22215.1; ALT_FRAME; mRNA.
DR EMBL; AK011620; BAB27739.1; -; mRNA.
DR EMBL; AK154328; BAE32517.1; -; mRNA.
DR EMBL; BC019995; AAH19995.1; -; mRNA.
DR CCDS; CCDS20752.1; -.
DR RefSeq; NP_079600.1; NM_025324.2.
DR RefSeq; XP_006540339.1; XM_006540276.2.
DR RefSeq; XP_006540340.1; XM_006540277.3.
DR RefSeq; XP_011248972.1; XM_011250670.1.
DR AlphaFoldDB; Q9D0B1; -.
DR SMR; Q9D0B1; -.
DR BioGRID; 211183; 1.
DR IntAct; Q9D0B1; 1.
DR STRING; 10090.ENSMUSP00000083533; -.
DR PhosphoSitePlus; Q9D0B1; -.
DR EPD; Q9D0B1; -.
DR MaxQB; Q9D0B1; -.
DR PaxDb; Q9D0B1; -.
DR PRIDE; Q9D0B1; -.
DR ProteomicsDB; 299585; -.
DR DNASU; 66056; -.
DR Ensembl; ENSMUST00000086349; ENSMUSP00000083533; ENSMUSG00000051184.
DR Ensembl; ENSMUST00000207901; ENSMUSP00000146921; ENSMUSG00000051184.
DR Ensembl; ENSMUST00000209030; ENSMUSP00000147095; ENSMUSG00000051184.
DR GeneID; 66056; -.
DR KEGG; mmu:66056; -.
DR UCSC; uc009ezj.1; mouse.
DR CTD; 66056; -.
DR MGI; MGI:1916740; Zfp524.
DR VEuPathDB; HostDB:ENSMUSG00000051184; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163198; -.
DR HOGENOM; CLU_1057530_0_0_1; -.
DR InParanoid; Q9D0B1; -.
DR OMA; PKRAPHF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9D0B1; -.
DR TreeFam; TF338348; -.
DR BioGRID-ORCS; 66056; 1 hit in 71 CRISPR screens.
DR PRO; PR:Q9D0B1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q9D0B1; protein.
DR Bgee; ENSMUSG00000051184; Expressed in granulocyte and 146 other tissues.
DR Genevisible; Q9D0B1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:1990837; F:sequence-specific double-stranded DNA binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 2.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..321
FT /note="Zinc finger protein 524"
FT /id="PRO_0000234580"
FT DNA_BIND 49..59
FT /note="A.T hook"
FT ZN_FING 109..131
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 137..159
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 165..187
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 193..216
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..80
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 86..105
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 248..321
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 259..274
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 255
FT /note="E -> G (in Ref. 1; BAB22215)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 321 AA; 34809 MW; 39F71B5061E40BAC CRC64;
MDNPSSDPLP STLSGEEEKP LALLPPVPRG RRGRPPGGAT TSNRTLKSSL PRKRGRPPRS
EQETPLTAPV DSGGSSDLLL IDDQGVPYTV PEGSAADGPQ GSGSKRAPHF CPVCLRAFPY
LSDLERHSIS HSELKPHVCK DCGKTFKRSS HLRRHCNIHA GLRPFRCVLC PRRFREAGEL
AHHHRIHSGE RPYQCPSCRV RFTEANTLRR HYKRKHPELV GMPVRLCPPN PRTQPLWDDD
EGIPVQEGVQ EESPEGKEPT WPISSTTSPL SGFTAGGSAG AGRGQEGQDT LVSGGIPTME
GDQKQGPKPL GPGAIGHPPV D
