ZN526_HUMAN
ID ZN526_HUMAN Reviewed; 670 AA.
AC Q8TF50; B3KV29; Q69YI2; Q96E24;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 02-OCT-2007, sequence version 2.
DT 03-AUG-2022, entry version 143.
DE RecName: Full=Zinc finger protein 526;
GN Name=ZNF526; Synonyms=KIAA1951;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=11853319; DOI=10.1093/dnares/8.6.319;
RA Nagase T., Kikuno R., Ohara O.;
RT "Prediction of the coding sequences of unidentified human genes. XXII. The
RT complete sequences of 50 new cDNA clones which code for large proteins.";
RL DNA Res. 8:319-327(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT PHE-511.
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 210-670.
RC TISSUE=Melanoma;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q8TF50; Q8TBE0: BAHD1; NbExp=3; IntAct=EBI-11035148, EBI-742750;
CC Q8TF50; Q9H7E9: C8orf33; NbExp=3; IntAct=EBI-11035148, EBI-715389;
CC Q8TF50; Q3B820: FAM161A; NbExp=3; IntAct=EBI-11035148, EBI-719941;
CC Q8TF50; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-11035148, EBI-6658203;
CC Q8TF50; O95363: FARS2; NbExp=3; IntAct=EBI-11035148, EBI-2513774;
CC Q8TF50; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-11035148, EBI-11959863;
CC Q8TF50; A0A024R4Z4: hCG_2042749; NbExp=3; IntAct=EBI-11035148, EBI-14231181;
CC Q8TF50; P61978-2: HNRNPK; NbExp=3; IntAct=EBI-11035148, EBI-7060731;
CC Q8TF50; Q14005-2: IL16; NbExp=3; IntAct=EBI-11035148, EBI-17178971;
CC Q8TF50; Q9C086: INO80B; NbExp=3; IntAct=EBI-11035148, EBI-715611;
CC Q8TF50; Q8NA54: IQUB; NbExp=3; IntAct=EBI-11035148, EBI-10220600;
CC Q8TF50; Q92993: KAT5; NbExp=3; IntAct=EBI-11035148, EBI-399080;
CC Q8TF50; P25800: LMO1; NbExp=3; IntAct=EBI-11035148, EBI-8639312;
CC Q8TF50; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-11035148, EBI-11742507;
CC Q8TF50; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-11035148, EBI-726739;
CC Q8TF50; Q9Y3B7: MRPL11; NbExp=3; IntAct=EBI-11035148, EBI-5453723;
CC Q8TF50; O43639: NCK2; NbExp=3; IntAct=EBI-11035148, EBI-713635;
CC Q8TF50; Q9Y5B8: NME7; NbExp=3; IntAct=EBI-11035148, EBI-744782;
CC Q8TF50; Q9BRP0: OVOL2; NbExp=3; IntAct=EBI-11035148, EBI-13007247;
CC Q8TF50; Q6TGC4: PADI6; NbExp=3; IntAct=EBI-11035148, EBI-10892722;
CC Q8TF50; Q96KB5: PBK; NbExp=3; IntAct=EBI-11035148, EBI-536853;
CC Q8TF50; O43189: PHF1; NbExp=3; IntAct=EBI-11035148, EBI-530034;
CC Q8TF50; Q13526: PIN1; NbExp=3; IntAct=EBI-11035148, EBI-714158;
CC Q8TF50; O43741: PRKAB2; NbExp=3; IntAct=EBI-11035148, EBI-1053424;
CC Q8TF50; Q99633: PRPF18; NbExp=3; IntAct=EBI-11035148, EBI-2798416;
CC Q8TF50; P98175: RBM10; NbExp=3; IntAct=EBI-11035148, EBI-721525;
CC Q8TF50; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-11035148, EBI-748391;
CC Q8TF50; P49903: SEPHS1; NbExp=3; IntAct=EBI-11035148, EBI-714091;
CC Q8TF50; Q5MJ10: SPANXN2; NbExp=3; IntAct=EBI-11035148, EBI-12023934;
CC Q8TF50; Q15560: TCEA2; NbExp=3; IntAct=EBI-11035148, EBI-710310;
CC Q8TF50; Q9NVV9: THAP1; NbExp=3; IntAct=EBI-11035148, EBI-741515;
CC Q8TF50; O43422: THAP12; NbExp=3; IntAct=EBI-11035148, EBI-2828217;
CC Q8TF50; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-11035148, EBI-725997;
CC Q8TF50; P26368-2: U2AF2; NbExp=3; IntAct=EBI-11035148, EBI-11097439;
CC Q8TF50; Q3SXR9: VCX2; NbExp=3; IntAct=EBI-11035148, EBI-11983741;
CC Q8TF50; Q9BW85: YJU2; NbExp=3; IntAct=EBI-11035148, EBI-10300345;
CC Q8TF50; O43167: ZBTB24; NbExp=3; IntAct=EBI-11035148, EBI-744471;
CC Q8TF50; Q15973: ZNF124; NbExp=3; IntAct=EBI-11035148, EBI-2555767;
CC Q8TF50; O43296: ZNF264; NbExp=3; IntAct=EBI-11035148, EBI-4395808;
CC Q8TF50; Q9H9D4: ZNF408; NbExp=3; IntAct=EBI-11035148, EBI-347633;
CC Q8TF50; Q7Z4V0: ZNF438; NbExp=3; IntAct=EBI-11035148, EBI-11962468;
CC Q8TF50; Q6ZNH5: ZNF497; NbExp=3; IntAct=EBI-11035148, EBI-10486136;
CC Q8TF50; Q96C55: ZNF524; NbExp=3; IntAct=EBI-11035148, EBI-10283126;
CC Q8TF50; Q86XF7: ZNF575; NbExp=3; IntAct=EBI-11035148, EBI-14069183;
CC Q8TF50; Q96N58: ZNF578; NbExp=3; IntAct=EBI-11035148, EBI-11955189;
CC Q8TF50; Q9H7X3: ZNF696; NbExp=3; IntAct=EBI-11035148, EBI-11090299;
CC Q8TF50; P36508: ZNF76; NbExp=3; IntAct=EBI-11035148, EBI-7254550;
CC Q8TF50; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-11035148, EBI-10251462;
CC Q8TF50; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-11035148, EBI-10240849;
CC Q8TF50; Q9Y2P0: ZNF835; NbExp=3; IntAct=EBI-11035148, EBI-5667516;
CC Q8TF50; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-11035148, EBI-11962574;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB85537.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AB075831; BAB85537.1; ALT_INIT; mRNA.
DR EMBL; AK122649; BAG53641.1; -; mRNA.
DR EMBL; CH471126; EAW57113.1; -; Genomic_DNA.
DR EMBL; BC013013; AAH13013.1; -; mRNA.
DR EMBL; AL833399; CAH10586.1; -; mRNA.
DR CCDS; CCDS12598.1; -.
DR RefSeq; NP_001300962.1; NM_001314033.2.
DR RefSeq; NP_597701.1; NM_133444.2.
DR AlphaFoldDB; Q8TF50; -.
DR SMR; Q8TF50; -.
DR BioGRID; 125475; 79.
DR IntAct; Q8TF50; 72.
DR STRING; 9606.ENSP00000301215; -.
DR CarbonylDB; Q8TF50; -.
DR iPTMnet; Q8TF50; -.
DR PhosphoSitePlus; Q8TF50; -.
DR BioMuta; ZNF526; -.
DR DMDM; 158706495; -.
DR EPD; Q8TF50; -.
DR jPOST; Q8TF50; -.
DR MassIVE; Q8TF50; -.
DR MaxQB; Q8TF50; -.
DR PaxDb; Q8TF50; -.
DR PeptideAtlas; Q8TF50; -.
DR PRIDE; Q8TF50; -.
DR ProteomicsDB; 74560; -.
DR Antibodypedia; 30899; 64 antibodies from 15 providers.
DR DNASU; 116115; -.
DR Ensembl; ENST00000301215.8; ENSP00000301215.2; ENSG00000167625.11.
DR GeneID; 116115; -.
DR KEGG; hsa:116115; -.
DR MANE-Select; ENST00000301215.8; ENSP00000301215.2; NM_133444.3; NP_597701.1.
DR UCSC; uc002osz.2; human.
DR CTD; 116115; -.
DR DisGeNET; 116115; -.
DR GeneCards; ZNF526; -.
DR HGNC; HGNC:29415; ZNF526.
DR HPA; ENSG00000167625; Low tissue specificity.
DR MIM; 614387; gene.
DR neXtProt; NX_Q8TF50; -.
DR OpenTargets; ENSG00000167625; -.
DR PharmGKB; PA134967668; -.
DR VEuPathDB; HostDB:ENSG00000167625; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162624; -.
DR HOGENOM; CLU_002678_24_3_1; -.
DR InParanoid; Q8TF50; -.
DR OMA; CGDCPQH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TF50; -.
DR TreeFam; TF350791; -.
DR PathwayCommons; Q8TF50; -.
DR SignaLink; Q8TF50; -.
DR BioGRID-ORCS; 116115; 14 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF526; human.
DR GenomeRNAi; 116115; -.
DR Pharos; Q8TF50; Tdark.
DR PRO; PR:Q8TF50; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TF50; protein.
DR Bgee; ENSG00000167625; Expressed in stromal cell of endometrium and 108 other tissues.
DR ExpressionAtlas; Q8TF50; baseline and differential.
DR Genevisible; Q8TF50; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..670
FT /note="Zinc finger protein 526"
FT /id="PRO_0000306875"
FT ZN_FING 57..79
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 108..130
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 140..163
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 305..327
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 332..354
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 360..382
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 388..409
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..465
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 472..494
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 500..522
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 528..550
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 573..595
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 168..196
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 217..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..443
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 601..621
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 169..193
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 228..259
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 419..443
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 606..621
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 94
FT /note="V -> A (in dbSNP:rs3810151)"
FT /id="VAR_035331"
FT VARIANT 511
FT /note="S -> F (in dbSNP:rs17850994)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_035332"
SQ SEQUENCE 670 AA; 73622 MW; 83C09EB3961765E8 CRC64;
MAEVVAEVAE MPTQMSPGAV EMSTPMSAEM MEMSTEVTEM TPGEALASSL FFQHHQFMCS
ECGSLYNTLE EVLSHQEQHM LAVSEEEALT TQNVGLEPEL VPGAEGPFQC GECSQLILSP
GELLAHQDAH LRESANQIQY QCWDCQELFP SPELWVAHRK AQHLSATVAE PPVPPPLPPP
TPLPPPSPPS EVKMEPYECP ECSTLCATPE EFLEHQGTHF DSLEKEERNG LEEEEEDDEE
DEEDDEEMED EEAMAEVGDD AVGGDESTAG WAQGCGDCPQ HQPSAGARRQ HRRTAHSPAS
ATHPFHCSQC QRSFSSANRL QAHGRAHVGG THECTTCSKV FKKAASLEQH LRLHRGEARY
LCVDCGRGFG TELTLVAHRR AHTANPLHRC RCGKTFSNMT KFLYHRRTHA GKSGAPPTGA
TAPPAPAEPT PPPPPPAPPA QLPCPQCSKS FASASRLSRH RRAVHGPPER RHRCGVCGKG
FKKLIHVRNH LRTHTGERPF QCHSCGKTFA SLANLSRHQL THTGARPYQC LDCGKRFTQS
SNLQQHRRLH LRPVAFARAP RLPITGLYNK SPYYCGTCGR WFRAMAGLRL HQRVHARART
LTLQPPRSPS PAPPPPPEPQ QTIMCTELGE TIAIIETSQP LALEDTLQLC QAALGASEAG
GLLQLDTAFV
