ZN526_MOUSE
ID ZN526_MOUSE Reviewed; 675 AA.
AC Q8BI66; Q4VA17; Q69Z58; Q8BIH7;
DT 02-OCT-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 145.
DE RecName: Full=Zinc finger protein 526;
GN Name=Znf526; Synonyms=Kiaa1951, Zfp526;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Spinal ganglion;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC STRAIN=129; TISSUE=Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-433.
RC TISSUE=Pancreatic islet;
RX PubMed=15368895; DOI=10.1093/dnares/11.3.205;
RA Okazaki N., Kikuno R., Ohara R., Inamoto S., Koseki H., Hiraoka S.,
RA Saga Y., Seino S., Nishimura M., Kaisho T., Hoshino K., Kitamura H.,
RA Nagase T., Ohara O., Koga H.;
RT "Prediction of the coding sequences of mouse homologues of KIAA gene: IV.
RT The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs
RT identified by screening of terminal sequences of cDNA clones randomly
RT sampled from size-fractionated libraries.";
RL DNA Res. 11:205-218(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8BI66-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8BI66-2; Sequence=VSP_028554, VSP_028555;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC34772.1; Type=Frameshift; Evidence={ECO:0000305};
CC Sequence=BAD32586.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAD32586.1; Type=Miscellaneous discrepancy; Note=Partially unspliced pre-RNA.; Evidence={ECO:0000305};
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DR EMBL; AK050839; BAC34430.1; -; mRNA.
DR EMBL; AK051798; BAC34772.1; ALT_FRAME; mRNA.
DR EMBL; BC096589; AAH96589.1; -; mRNA.
DR EMBL; AK173308; BAD32586.1; ALT_SEQ; Transcribed_RNA.
DR CCDS; CCDS20975.1; -. [Q8BI66-1]
DR RefSeq; NP_780645.1; NM_175436.5. [Q8BI66-1]
DR RefSeq; XP_006539778.1; XM_006539715.3. [Q8BI66-1]
DR RefSeq; XP_006539779.1; XM_006539716.2. [Q8BI66-1]
DR AlphaFoldDB; Q8BI66; -.
DR SMR; Q8BI66; -.
DR STRING; 10090.ENSMUSP00000053567; -.
DR PhosphoSitePlus; Q8BI66; -.
DR EPD; Q8BI66; -.
DR MaxQB; Q8BI66; -.
DR PaxDb; Q8BI66; -.
DR PRIDE; Q8BI66; -.
DR ProteomicsDB; 275292; -. [Q8BI66-1]
DR ProteomicsDB; 275293; -. [Q8BI66-2]
DR Antibodypedia; 30899; 64 antibodies from 15 providers.
DR DNASU; 210172; -.
DR Ensembl; ENSMUST00000055604; ENSMUSP00000053567; ENSMUSG00000046541. [Q8BI66-1]
DR GeneID; 210172; -.
DR KEGG; mmu:210172; -.
DR UCSC; uc009frw.1; mouse. [Q8BI66-1]
DR CTD; 210172; -.
DR MGI; MGI:2445181; Zfp526.
DR VEuPathDB; HostDB:ENSMUSG00000046541; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162624; -.
DR HOGENOM; CLU_002678_24_3_1; -.
DR InParanoid; Q8BI66; -.
DR OMA; CGDCPQH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BI66; -.
DR TreeFam; TF350791; -.
DR BioGRID-ORCS; 210172; 4 hits in 75 CRISPR screens.
DR ChiTaRS; Zfp526; mouse.
DR PRO; PR:Q8BI66; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BI66; protein.
DR Bgee; ENSMUSG00000046541; Expressed in gastrula and 74 other tissues.
DR Genevisible; Q8BI66; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..675
FT /note="Zinc finger protein 526"
FT /id="PRO_0000306876"
FT ZN_FING 56..78
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 108..130
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 140..163
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..416
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..470
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..600
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 160..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 606..625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 170..195
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 231..264
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 265..283
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 611..625
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 446..453
FT /note="QLPCPQCP -> LLLSRLFG (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028554"
FT VAR_SEQ 454..675
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_028555"
FT CONFLICT 37
FT /note="T -> I (in Ref. 1; BAC34772)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 675 AA; 73971 MW; 7B9D84985B85AAC9 CRC64;
MAEMVAEAAE IPTQSSGAVE ISTAVSGELA EMATAVTEMT SGEALASSLF FQHHQFMCSE
CGSLYNTLEE VLSHQEQHLL TMSEEETLTT QDAGLEPELV PSTGEGPFQC GECSQLILSP
SELLAHQDAH LQESASQIQY QCGDCQELFP SPELWVAHRK TQHLSSAADE PPSPLPPPTP
PPPPPPPPPP PPPEVKMEPY ECPECSTLCA TPEEFLEHQG THFDSLEKEE HNGLEEEEED
EEEGEEEEDD DDEETDEEEA SSELTADDTG SNKSTADSAQ SCGDCPQHCT SSGARHKHRR
ASHGPASATH AFHCSQCQRS FSSANRLVAH GRAHVGGTHE CTTCSKVFKK AASLEQHQRL
HRGEARYLCV DCGRGFGTEL TLVAHRRAHT ANPLHRCRCG KTFSNMTKFL YHRRTHTGKS
GTPTRVATVS PAPAEPTPPP LPPPAQLPCP QCPKSFASAS RLSRHRRAVH GPPERRHRCG
VCGKGFKKLV HVRNHLRTHT GERPFQCHSC GKTFASLANL SRHQLTHTGV RPYQCLDCGK
RFTQSSNLQQ HRRLHLRPVA FARAPRLPIT GLYNKSPYYC GTCGRWFRAM AGLRLHQRVH
ARARSLTLQP PRSPSPVPPP PPEPQQTIMC TELGETIAII ETSQPLALED TLQLCQAALG
ASEASGLLQL DTAFV
