ZN534_HUMAN
ID ZN534_HUMAN Reviewed; 674 AA.
AC Q76KX8; Q76KX9;
DT 18-MAY-2010, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Zinc finger protein 534;
DE AltName: Full=KRAB domain only protein 3;
GN Name=ZNF534; Synonyms=KRBO3;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RA Maegawa S., Shiraishi M., Otsuka S., Meguro M., Mitsuya K., Nanba E.,
RA Oshimura M.;
RT "Identification of a novel Kruppel-like zinc finger protein.";
RL Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q76KX8; Q9UPQ3: AGAP1; NbExp=3; IntAct=EBI-17208605, EBI-7159788;
CC Q76KX8; P02747: C1QC; NbExp=3; IntAct=EBI-17208605, EBI-1220222;
CC Q76KX8; Q9Y284: WDR83OS; NbExp=3; IntAct=EBI-17208605, EBI-6309120;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q76KX8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q76KX8-2; Sequence=VSP_039177;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AB086839; BAD13515.1; -; mRNA.
DR EMBL; AB086840; BAD13516.1; -; mRNA.
DR EMBL; AC010332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS46165.1; -. [Q76KX8-1]
DR CCDS; CCDS46166.1; -. [Q76KX8-2]
DR RefSeq; NP_001137410.1; NM_001143938.1. [Q76KX8-2]
DR RefSeq; NP_001137411.1; NM_001143939.1. [Q76KX8-1]
DR AlphaFoldDB; Q76KX8; -.
DR SMR; Q76KX8; -.
DR BioGRID; 127069; 3.
DR IntAct; Q76KX8; 4.
DR STRING; 9606.ENSP00000327538; -.
DR iPTMnet; Q76KX8; -.
DR PhosphoSitePlus; Q76KX8; -.
DR BioMuta; ZNF534; -.
DR DMDM; 74749834; -.
DR EPD; Q76KX8; -.
DR jPOST; Q76KX8; -.
DR MassIVE; Q76KX8; -.
DR MaxQB; Q76KX8; -.
DR PaxDb; Q76KX8; -.
DR PeptideAtlas; Q76KX8; -.
DR PRIDE; Q76KX8; -.
DR ProteomicsDB; 68678; -. [Q76KX8-1]
DR ProteomicsDB; 68679; -. [Q76KX8-2]
DR Antibodypedia; 32599; 16 antibodies from 7 providers.
DR DNASU; 147658; -.
DR Ensembl; ENST00000332323.10; ENSP00000327538.6; ENSG00000198633.11. [Q76KX8-1]
DR Ensembl; ENST00000433050.6; ENSP00000391358.1; ENSG00000198633.11. [Q76KX8-2]
DR GeneID; 147658; -.
DR KEGG; hsa:147658; -.
DR MANE-Select; ENST00000433050.6; ENSP00000391358.1; NM_001143938.3; NP_001137410.1. [Q76KX8-2]
DR UCSC; uc002pzk.4; human. [Q76KX8-1]
DR CTD; 147658; -.
DR GeneCards; ZNF534; -.
DR HGNC; HGNC:26337; ZNF534.
DR HPA; ENSG00000198633; Tissue enhanced (brain, retina, testis).
DR neXtProt; NX_Q76KX8; -.
DR OpenTargets; ENSG00000198633; -.
DR PharmGKB; PA134911920; -.
DR VEuPathDB; HostDB:ENSG00000198633; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000165725; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q76KX8; -.
DR OMA; AFLVRHW; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q76KX8; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q76KX8; -.
DR SignaLink; Q76KX8; -.
DR BioGRID-ORCS; 147658; 5 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF534; human.
DR GenomeRNAi; 147658; -.
DR Pharos; Q76KX8; Tdark.
DR PRO; PR:Q76KX8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q76KX8; protein.
DR Bgee; ENSG00000198633; Expressed in cortical plate and 81 other tissues.
DR ExpressionAtlas; Q76KX8; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 14.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..674
FT /note="Zinc finger protein 534"
FT /id="PRO_0000394145"
FT DOMAIN 8..92
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 199..221
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 227..249
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 255..277
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 283..305
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 311..333
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..417
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 423..445
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 451..473
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 479..501
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 507..529
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 535..557
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 563..585
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 591..613
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 619..641
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 647..669
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 48..60
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|Ref.1"
FT /id="VSP_039177"
SQ SEQUENCE 674 AA; 77167 MW; A1E6226FC4FE55EE CRC64;
MALTQGQLSF SDVAIEFSQE EWKCLDPGQK ALYRDVMLEN YRNLVSLGED NVRPEACICS
GICLPDLSVT SMLEQKRDPW TLQSEVKIIN NPDGRECIKG VNTEKSSKLG SSAGNKSLKN
QHGLTLQLHL TEWQPFQAVR NIYGCKHVEK SISDNSSVSP VQISFFSVKT HIFNNYRNDF
LFSTLLPQEQ KVHIREKPYG CNEHGKVFRV SSSLTNRQVI HIADKTYKCS DCGEIFSSNS
NFAQHQRIHT GEKPYKYNEC GKVFNQNSHL AQHQKIHTGQ KPYNNKECGK VFSHHAYLAQ
HRKIHTGEKP YKCSECGKAF SVCSSLTAHL VIHTGEKPYD CKECGKVFRH KSSLTTHQTV
HTGERPYKCN ECGKGFSRIA FLARHRKVHT GEKPYKCNEC GKVFIGNSRL ARHRKIHTGG
RRYKCNECGK AFRTCSDLTA HLLIHTGEKP YECIDCGKVF RHKSSLTYHC RIHTGEKPYK
CNECGKVFSQ NSNLQRHRKI HTGEKLYKCN ECGKVFRQNS HLAQHRDIHT GEKPYSCNEC
GKVFRRNSHL VRHRNVHTGE KPYSCNECGK VFSRNSHLAR HRNIHTGEKP HSCNECGKVF
SRNSHLARHR KIHTGEKLYK CNECSKVFSR NSRLAQHRNI HTGVKPYSCN ECGKVFSKNS
ILVQHCSIHT REKP
