ID   ZN541_MACFA             Reviewed;         804 AA.
AC   Q4R2Z8;
DT   25-OCT-2005, integrated into UniProtKB/Swiss-Prot.
DT   20-JAN-2009, sequence version 2.
DT   25-MAY-2022, entry version 71.
DE   RecName: Full=Zinc finger protein 541;
DE   Flags: Fragment;
GN   Name=ZNF541; ORFNames=QtsA-20632;
OS   Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9541;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   International consortium for macaque cDNA sequencing and analysis;
RT   "DNA sequences of macaque genes expressed in brain or testis and its
RT   evolutionary implications.";
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Component of some chromatin remodeling multiprotein complex
CC       that plays a role during spermatogenesis.
CC       {ECO:0000250|UniProtKB:Q0GGX2}.
CC   -!- SUBUNIT: Interacts with DNTTIP1. Identified in a complex with KCDT19,
CC       HDAC1 and HSPA2s. Component of a histone deacetylase complex containing
CC       DNTTIP1, ZNF541, HDAC1 and HDAC2. {ECO:0000250|UniProtKB:Q0GGX2,
CC       ECO:0000250|UniProtKB:Q9H0D2}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q0GGX2,
CC       ECO:0000255|PROSITE-ProRule:PRU00512, ECO:0000255|PROSITE-
CC       ProRule:PRU00624}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=BAE02521.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AB179470; BAE02521.1; ALT_INIT; mRNA.
DR   AlphaFoldDB; Q4R2Z8; -.
DR   SMR; Q4R2Z8; -.
DR   STRING; 9541.XP_005589764.1; -.
DR   eggNOG; KOG1721; Eukaryota.
DR   eggNOG; KOG4167; Eukaryota.
DR   Proteomes; UP000233100; Unplaced.
DR   GO; GO:0000118; C:histone deacetylase complex; ISS:UniProtKB.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR   GO; GO:0007283; P:spermatogenesis; IEA:UniProtKB-KW.
DR   InterPro; IPR000949; ELM2_dom.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR001005; SANT/Myb.
DR   InterPro; IPR017884; SANT_dom.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF01448; ELM2; 1.
DR   SMART; SM01189; ELM2; 1.
DR   SMART; SM00717; SANT; 1.
DR   SMART; SM00355; ZnF_C2H2; 2.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS51156; ELM2; 1.
DR   PROSITE; PS51293; SANT; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 2.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 2.
PE   2: Evidence at transcript level;
KW   Developmental protein; Differentiation; Metal-binding; Nucleus;
KW   Reference proteome; Repeat; Repressor; Spermatogenesis; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN           <1..804
FT                   /note="Zinc finger protein 541"
FT                   /id="PRO_0000197137"
FT   DOMAIN          509..601
FT                   /note="ELM2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00512"
FT   DOMAIN          616..667
FT                   /note="SANT"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00624"
FT   ZN_FING         285..307
FT                   /note="C2H2-type 1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   ZN_FING         747..769
FT                   /note="C2H2-type 2"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          21..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          133..197
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          379..426
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..743
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        379..396
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        680..718
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        719..741
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   804 AA;  88360 MW;  2B0690CBFC31A59B CRC64;
     QMQVFQMITK SQRIFSHAQV SKASSQLPAP EGKPAALRPL QGPWPQQLPP LAPAVDSLNA
     GPGNPEAEGS PARRRKTTPG VAREASPGNT RRDAKGGLKV AAVPTPLAAP SLDPSRNPDI
     SSLAKQLRSS KGTLDLGDIF PSTGQRQTQL GGEELPGASL PGKQAPAENG AVSGTTKGEK
     GPPCSRGGGY RLLGNPRAPR FSGFRKEKAK MDMCCAASPS QVAMASFSSA GPPADPSKSK
     LTIFSRIQGG NIYRLPHPVK EENVAGGGNQ QNGGSTDWTE PRSTFICKNC SQMFYTEKGL
     SSHMCFHSDQ WPSPRGKQEP QVFGTEFCKP LRQVLRPEGD RHSPPGAKKP LDSTAAAPLV
     VPHSIPVVPV TRHVGSMAME QEKDGEERDS KESSQQRKRK KRPPPKRLFI PPPPSTAGEP
     GPAGCHQSRL RSPMFLVDRL LKGLFQCSPY TPPPMLSPIR EGSGVYFNTL CSTSTQASPD
     QLISSMLDQV DGSFGICVVK DDTKISIEPH INIGSRFQAE IPELQERSLA GIDEHVASLV
     WKPWGDMMIN PETQDRVTEL CNVACSSVMP GGGTNLELAL HCLHEAQGNV QVALETLLLR
     GPHKPPTHLL ADYRYTGSDV WTPIEKRLFK KAFYAHKKDF YLIHKTIQTK TVAQCVEYYY
     IWKKMIKFDC GRAPGLEKRV KREPEEVERT EEKVPCSPRE RPSHHPIPEL KIKTKSYRRE
     SILSSSPNAG PKRTPEPSGS VESQGIFPCR ECERVFDKIK SRNAHMKRHR LQDHVEPIVR
     VKWPVKPFQL KEEELGADIG PLQW