ZN547_HUMAN
ID ZN547_HUMAN Reviewed; 402 AA.
AC Q8IVP9; A8K5Z9; Q96NC4;
DT 22-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 07-DEC-2004, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 547;
GN Name=ZNF547;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Neuroblastoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8IVP9; Q9NWQ4-1: GPATCH2L; NbExp=3; IntAct=EBI-12895421, EBI-11959863;
CC Q8IVP9; Q96A72: MAGOHB; NbExp=3; IntAct=EBI-12895421, EBI-746778;
CC Q8IVP9; Q9UPY8: MAPRE3; NbExp=3; IntAct=EBI-12895421, EBI-726739;
CC Q8IVP9; Q92824-2: PCSK5; NbExp=3; IntAct=EBI-12895421, EBI-11956269;
CC Q8IVP9; O15160: POLR1C; NbExp=3; IntAct=EBI-12895421, EBI-1055079;
CC Q8IVP9; Q9BWG6: SCNM1; NbExp=3; IntAct=EBI-12895421, EBI-748391;
CC Q8IVP9; P15622-3: ZNF250; NbExp=3; IntAct=EBI-12895421, EBI-10177272;
CC Q8IVP9; Q9Y3S2: ZNF330; NbExp=5; IntAct=EBI-12895421, EBI-373456;
CC Q8IVP9; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-12895421, EBI-740727;
CC Q8IVP9; Q96SQ5: ZNF587; NbExp=3; IntAct=EBI-12895421, EBI-6427977;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8IVP9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8IVP9-2; Sequence=VSP_016347, VSP_016348;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: The gene of ZNF547 share a non-coding exon with TRAPPC2P.
CC {ECO:0000305}.
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DR EMBL; AK055662; BAB70979.1; -; mRNA.
DR EMBL; AK291464; BAF84153.1; -; mRNA.
DR EMBL; CH471135; EAW72497.1; -; Genomic_DNA.
DR EMBL; BC042681; AAH42681.2; -; mRNA.
DR CCDS; CCDS33131.1; -. [Q8IVP9-1]
DR RefSeq; NP_775902.2; NM_173631.3. [Q8IVP9-1]
DR AlphaFoldDB; Q8IVP9; -.
DR SMR; Q8IVP9; -.
DR BioGRID; 129822; 22.
DR IntAct; Q8IVP9; 10.
DR STRING; 9606.ENSP00000282282; -.
DR iPTMnet; Q8IVP9; -.
DR PhosphoSitePlus; Q8IVP9; -.
DR BioMuta; ZNF547; -.
DR DMDM; 74762478; -.
DR MassIVE; Q8IVP9; -.
DR MaxQB; Q8IVP9; -.
DR PaxDb; Q8IVP9; -.
DR PeptideAtlas; Q8IVP9; -.
DR PRIDE; Q8IVP9; -.
DR ProteomicsDB; 70751; -. [Q8IVP9-1]
DR ProteomicsDB; 70752; -. [Q8IVP9-2]
DR Antibodypedia; 19645; 102 antibodies from 18 providers.
DR DNASU; 284306; -.
DR Ensembl; ENST00000282282.4; ENSP00000282282.3; ENSG00000152433.15. [Q8IVP9-1]
DR GeneID; 284306; -.
DR KEGG; hsa:284306; -.
DR MANE-Select; ENST00000282282.4; ENSP00000282282.3; NM_173631.4; NP_775902.2.
DR UCSC; uc002qol.4; human. [Q8IVP9-1]
DR CTD; 284306; -.
DR DisGeNET; 284306; -.
DR GeneCards; ZNF547; -.
DR HGNC; HGNC:26432; ZNF547.
DR HPA; ENSG00000152433; Low tissue specificity.
DR neXtProt; NX_Q8IVP9; -.
DR OpenTargets; ENSG00000152433; -.
DR PharmGKB; PA134931565; -.
DR VEuPathDB; HostDB:ENSG00000152433; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164762; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q8IVP9; -.
DR OMA; AFSHKHK; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IVP9; -.
DR TreeFam; TF337732; -.
DR PathwayCommons; Q8IVP9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8IVP9; -.
DR BioGRID-ORCS; 284306; 9 hits in 1086 CRISPR screens.
DR ChiTaRS; ZNF547; human.
DR GenomeRNAi; 284306; -.
DR Pharos; Q8IVP9; Tdark.
DR PRO; PR:Q8IVP9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IVP9; protein.
DR Bgee; ENSG00000152433; Expressed in cerebellar hemisphere and 107 other tissues.
DR ExpressionAtlas; Q8IVP9; baseline and differential.
DR Genevisible; Q8IVP9; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..402
FT /note="Zinc finger protein 547"
FT /id="PRO_0000047644"
FT DOMAIN 11..82
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 87..109
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 156..178
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 184..206
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 212..234
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 378..400
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 346..353
FT /note="HTGERPYE -> YTEEESFQ (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016347"
FT VAR_SEQ 354..402
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016348"
SQ SEQUENCE 402 AA; 45956 MW; 5085F3EBA203C411 CRC64;
MAEMNPAQGH VVFEDVAIYF SQEEWGHLDE AQRLLYRDVM LENLALLSSL GCCHGAEDEE
APLEPGVSVG VSQVMAPKPC LSTQNTQPCE TCSSLLKDIL RLAEHDGTHP EQGLYTCPAH
LHQHQKEQIR EKLSRGDGGR PTFVKNHRVH MAGKTFLCSE CGKAFSHKHK LSDHQKIHTG
ERTYKCSKCG ILFMERSTLN RHQRTHTGER PYECNECGKA FLCKSHLVRH QTIHSGERPY
ECSECGKLFM WSSTLITHQR VHTGKRPYGC SECGKFFKCN SNLFRHYRIH TGKRSYGCSE
CGKFFMERST LSRHQRVHTG ERPYECNECG KFFSLKSVLI QHQRVHTGER PYECSECGKA
FLTKSHLICH QTVHTAAKQC SECGKFFRYN STLLRHQKVH TG
