ID   CC85C_XENTR             Reviewed;         391 AA.
AC   Q0V989;
DT   22-JUL-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-SEP-2006, sequence version 1.
DT   03-AUG-2022, entry version 70.
DE   RecName: Full=Coiled-coil domain-containing protein 85C;
GN   Name=ccdc85c;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=N6; TISSUE=Lung, and Oviduct;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in cell-cell adhesion and epithelium
CC       development through its interaction with proteins of the beta-catenin
CC       family (By similarity). May play an important role in cortical
CC       development, especially in the maintenance of radial glia (By
CC       similarity). {ECO:0000250|UniProtKB:A6NKD9,
CC       ECO:0000250|UniProtKB:E9Q6B2}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction
CC       {ECO:0000250|UniProtKB:E9Q6B2}. Cell junction, adherens junction
CC       {ECO:0000250|UniProtKB:A6NKD9}.
CC   -!- SIMILARITY: Belongs to the CCDC85 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC121701; AAI21702.1; -; mRNA.
DR   EMBL; BC160578; AAI60578.1; -; mRNA.
DR   RefSeq; NP_001072445.1; NM_001078977.1.
DR   AlphaFoldDB; Q0V989; -.
DR   SMR; Q0V989; -.
DR   STRING; 8364.ENSXETP00000054276; -.
DR   PaxDb; Q0V989; -.
DR   DNASU; 779899; -.
DR   Ensembl; ENSXETT00000054276; ENSXETP00000054276; ENSXETG00000025464.
DR   GeneID; 779899; -.
DR   KEGG; xtr:779899; -.
DR   CTD; 317762; -.
DR   Xenbase; XB-GENE-5853436; ccdc85c.
DR   eggNOG; KOG3819; Eukaryota.
DR   HOGENOM; CLU_028762_0_0_1; -.
DR   InParanoid; Q0V989; -.
DR   OMA; CENERMK; -.
DR   OrthoDB; 1393196at2759; -.
DR   PhylomeDB; Q0V989; -.
DR   TreeFam; TF320243; -.
DR   Proteomes; UP000008143; Chromosome 8.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000025464; Expressed in testis and 37 other tissues.
DR   GO; GO:0005912; C:adherens junction; IEA:UniProtKB-SubCell.
DR   GO; GO:0043296; C:apical junction complex; IBA:GO_Central.
DR   GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR   InterPro; IPR019359; CCDC85.
DR   PANTHER; PTHR13546; PTHR13546; 1.
DR   Pfam; PF10226; CCDC85; 1.
PE   2: Evidence at transcript level;
KW   Cell junction; Coiled coil; Developmental protein; Reference proteome;
KW   Tight junction.
FT   CHAIN           1..391
FT                   /note="Coiled-coil domain-containing protein 85C"
FT                   /id="PRO_0000345414"
FT   REGION          155..238
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          278..303
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          19..86
FT                   /evidence="ECO:0000255"
FT   COILED          116..146
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        158..193
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        208..224
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   391 AA;  44298 MW;  FAEF71610823A12C CRC64;
     MAKHCQGAAA EDIGTISDEE LLRWSKEELA KRLRKVENEK MSLMVEHGNM MKDVNRRLQV
     HLHEIRGLKE VNQKLQDDNQ ELRELCCFLD DDRQKGKKLS REWQRFGRHS ATMMWKEVGV
     YQQKLKELEA KQESLIRDNL ELKEIILMLD EERNGAGSRS SIDSQNSLTN LNGSSGPRDV
     GDGSSTSSTG SAGSPDHHHH HHHHTKPTEN KAGTVRKSTD DLSIPPHHRS IPNGLNDSST
     TYIRQLETRV KLLEDDNKLL SQHSTSGELR TLRKGLSPYH SESQLSPLPQ YQEPLQNGST
     RVTPEISSTA PAGYIPVVQK PEAVVHAMKV LEVHENLDRQ MSDTYEEDLS EKEKAIVREM
     CNVVWRKLGD ATNSKPSIRQ HLSGNQFKGP L