ZN555_HUMAN
ID ZN555_HUMAN Reviewed; 628 AA.
AC Q8NEP9; A8KA89; K7EQM2; Q8NA46; Q96MP1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-JAN-2009, sequence version 4.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 555;
GN Name=ZNF555;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3).
RC TISSUE=Testis, and Trachea;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Colon endothelium;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS ASP-107;
RP ASN-194 AND THR-515.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8NEP9; O95273: CCNDBP1; NbExp=4; IntAct=EBI-10270752, EBI-748961;
CC Q8NEP9; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-10270752, EBI-739624;
CC Q8NEP9; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-10270752, EBI-10172290;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q8NEP9-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8NEP9-2; Sequence=VSP_018382, VSP_018383, VSP_018384;
CC Name=3;
CC IsoId=Q8NEP9-4; Sequence=VSP_018382;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK093163; BAC04082.1; -; mRNA.
DR EMBL; AK292954; BAF85643.1; -; mRNA.
DR EMBL; BX647423; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC006130; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC022022; AAH22022.2; -; mRNA.
DR CCDS; CCDS12096.1; -. [Q8NEP9-1]
DR CCDS; CCDS59329.1; -. [Q8NEP9-4]
DR RefSeq; NP_001166246.1; NM_001172775.1. [Q8NEP9-4]
DR RefSeq; NP_690004.4; NM_152791.4. [Q8NEP9-1]
DR AlphaFoldDB; Q8NEP9; -.
DR SMR; Q8NEP9; -.
DR BioGRID; 127136; 12.
DR IntAct; Q8NEP9; 6.
DR STRING; 9606.ENSP00000334853; -.
DR iPTMnet; Q8NEP9; -.
DR PhosphoSitePlus; Q8NEP9; -.
DR BioMuta; ZNF555; -.
DR DMDM; 221222537; -.
DR EPD; Q8NEP9; -.
DR jPOST; Q8NEP9; -.
DR MassIVE; Q8NEP9; -.
DR MaxQB; Q8NEP9; -.
DR PaxDb; Q8NEP9; -.
DR PeptideAtlas; Q8NEP9; -.
DR PRIDE; Q8NEP9; -.
DR ProteomicsDB; 73197; -. [Q8NEP9-1]
DR ProteomicsDB; 73198; -. [Q8NEP9-2]
DR Antibodypedia; 10850; 166 antibodies from 19 providers.
DR DNASU; 148254; -.
DR Ensembl; ENST00000334241.9; ENSP00000334853.3; ENSG00000186300.12. [Q8NEP9-1]
DR Ensembl; ENST00000591539.1; ENSP00000467893.1; ENSG00000186300.12. [Q8NEP9-4]
DR GeneID; 148254; -.
DR KEGG; hsa:148254; -.
DR MANE-Select; ENST00000334241.9; ENSP00000334853.3; NM_152791.5; NP_690004.4.
DR UCSC; uc002lwn.5; human. [Q8NEP9-1]
DR CTD; 148254; -.
DR DisGeNET; 148254; -.
DR GeneCards; ZNF555; -.
DR HGNC; HGNC:28382; ZNF555.
DR HPA; ENSG00000186300; Low tissue specificity.
DR neXtProt; NX_Q8NEP9; -.
DR OpenTargets; ENSG00000186300; -.
DR PharmGKB; PA134956715; -.
DR VEuPathDB; HostDB:ENSG00000186300; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163425; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8NEP9; -.
DR OMA; RTYACKL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8NEP9; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q8NEP9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8NEP9; -.
DR BioGRID-ORCS; 148254; 10 hits in 1094 CRISPR screens.
DR GenomeRNAi; 148254; -.
DR Pharos; Q8NEP9; Tdark.
DR PRO; PR:Q8NEP9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8NEP9; protein.
DR Bgee; ENSG00000186300; Expressed in amniotic fluid and 174 other tissues.
DR ExpressionAtlas; Q8NEP9; baseline and differential.
DR Genevisible; Q8NEP9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..628
FT /note="Zinc finger protein 555"
FT /id="PRO_0000234588"
FT DOMAIN 4..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 172..194
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 200..222
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 228..250
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 256..278
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 284..306
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 340..362
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 368..390
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 396..418
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 424..446
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 452..474
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 480..502
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 508..530
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 536..558
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 564..586
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 105
FT /note="Missing (in isoform 2 and isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018382"
FT VAR_SEQ 451..453
FT /note="PYE -> LYK (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018383"
FT VAR_SEQ 460..543
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018384"
FT VARIANT 107
FT /note="N -> D (in dbSNP:rs17856649)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054223"
FT VARIANT 137
FT /note="P -> L (in dbSNP:rs36012545)"
FT /id="VAR_054224"
FT VARIANT 194
FT /note="H -> N (in dbSNP:rs17851955)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_054225"
FT VARIANT 515
FT /note="K -> T (in dbSNP:rs17856648)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_026295"
FT CONFLICT 304
FT /note="I -> T (in Ref. 1; BAF85643)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 628 AA; 73084 MW; D9C3B651D0B2FDE0 CRC64;
MDSVVFEDVA VDFTLEEWAL LDSAQRDLYR DVMLETFQNL ASVDDETQFK ASGSVSQQDI
YGEKIPKESK IATFTRNVSW ASVLGKIWDS LSIEDQTTNQ GRNLSRNHGL ERLCESNDQC
GEALSQIPHL NLYKKIPPGV KQYEYNTYGK VFMHRRTSLK SPITVHTGHK PYQCQECGQA
YSCRSHLRMH VRTHNGERPY VCKLCGKTFP RTSSLNRHVR IHTAEKTYEC KQCGKAFIDF
SSLTSHLRSH TGEKPYKCKE CGKAFSYSST FRRHTITHTG EKPYKCKECA EAFSYSSTFR
RHMISHTGEK PHKCKECGEA FSYSSAFRRH MITHTGEKPY ECKQCGKTFI YLQSFRRHER
IHTGEKPYEC KQCGKTFIYP QSFRRHERTH GGEKPYECNQ CGKAFSHPSS FRGHMRVHTG
EKPYECKQCG KTFNWPISLR KHMRTHTREK PYECKQCGKA FSLSACFREH VRMHPEDKSY
ECKLCGKAFY CHISLQKHMR RHTAEKLYKC KQCGKAFSWP ELLQQHVRTH TVEKPYECKE
CGKVFKWPSS LPIHMRLHTG EKPYQCKHCG KAFNCSSSLR RHVRIHTTEK QYKCNVGHPP
ANEFMCSASE KSHQERDLIK VVNMVLPL
