ZN556_HUMAN
ID ZN556_HUMAN Reviewed; 456 AA.
AC Q9HAH1; Q96GM3;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Zinc finger protein 556;
GN Name=ZNF556;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Muscle;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK021699; BAB13878.1; -; mRNA.
DR EMBL; BC009374; AAH09374.1; -; mRNA.
DR CCDS; CCDS12097.1; -.
DR RefSeq; NP_001287772.1; NM_001300843.1.
DR RefSeq; NP_079243.1; NM_024967.2.
DR AlphaFoldDB; Q9HAH1; -.
DR SMR; Q9HAH1; -.
DR BioGRID; 123082; 14.
DR IntAct; Q9HAH1; 10.
DR STRING; 9606.ENSP00000302603; -.
DR GlyGen; Q9HAH1; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q9HAH1; -.
DR PhosphoSitePlus; Q9HAH1; -.
DR BioMuta; ZNF556; -.
DR DMDM; 74762747; -.
DR jPOST; Q9HAH1; -.
DR MassIVE; Q9HAH1; -.
DR MaxQB; Q9HAH1; -.
DR PaxDb; Q9HAH1; -.
DR PeptideAtlas; Q9HAH1; -.
DR PRIDE; Q9HAH1; -.
DR ProteomicsDB; 81403; -.
DR Antibodypedia; 10860; 100 antibodies from 18 providers.
DR DNASU; 80032; -.
DR Ensembl; ENST00000307635.3; ENSP00000302603.2; ENSG00000172000.7.
DR GeneID; 80032; -.
DR KEGG; hsa:80032; -.
DR MANE-Select; ENST00000307635.3; ENSP00000302603.2; NM_024967.3; NP_079243.1.
DR UCSC; uc002lwp.2; human.
DR CTD; 80032; -.
DR GeneCards; ZNF556; -.
DR HGNC; HGNC:25669; ZNF556.
DR HPA; ENSG00000172000; Group enriched (brain, fallopian tube, ovary, skeletal muscle, tongue).
DR neXtProt; NX_Q9HAH1; -.
DR OpenTargets; ENSG00000172000; -.
DR PharmGKB; PA134949188; -.
DR VEuPathDB; HostDB:ENSG00000172000; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164313; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q9HAH1; -.
DR OMA; PKSFRVH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9HAH1; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q9HAH1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9HAH1; -.
DR BioGRID-ORCS; 80032; 12 hits in 1089 CRISPR screens.
DR GenomeRNAi; 80032; -.
DR Pharos; Q9HAH1; Tdark.
DR PRO; PR:Q9HAH1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9HAH1; protein.
DR Bgee; ENSG00000172000; Expressed in secondary oocyte and 71 other tissues.
DR ExpressionAtlas; Q9HAH1; baseline and differential.
DR Genevisible; Q9HAH1; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..456
FT /note="Zinc finger protein 556"
FT /id="PRO_0000274876"
FT DOMAIN 4..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 147..169
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 175..197
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 203..225
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 231..253
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 425..447
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 93..125
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 331..365
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 386..406
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 93..118
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 137
FT /note="R -> C (in dbSNP:rs10421121)"
FT /id="VAR_030355"
FT VARIANT 146
FT /note="R -> L (in dbSNP:rs35499960)"
FT /id="VAR_052863"
FT VARIANT 353
FT /note="A -> T (in dbSNP:rs35296337)"
FT /id="VAR_052864"
FT VARIANT 428
FT /note="E -> K (in dbSNP:rs35494032)"
FT /id="VAR_052865"
SQ SEQUENCE 456 AA; 51581 MW; 9C52FF6C12AA88EB CRC64;
MDTVVFEDVV VDFTLEEWAL LNPAQRKLYR DVMLETFKHL ASVDNEAQLK ASGSISQQDT
SGEKLSLKQK IEKFTRKNIW ASLLGKNWEE HSVKDKHNTK ERHLSRNPRV ERPCKSSKGN
KRGRTFRKTR NCNRHLRKNC CTSVRRYECS QCGKLFTHSS SLIRHKRAHS GQKLYKCKEC
GKAFSRPSYL QTHEKTHSGE KPYACQSCGK TFLRSHSLTE HVRTHTGEKP YECGQCGKGF
SCPKSFRAHV MMHAGGRPYE CKHCGKAFRC QKSFRVHMIM HAGGRPYECK QCGKAYCWAT
SFQRHVRIHN GEKPYKCGKC GKAFGWPSSL HKHARTHAKK KPVSGGSVGK SSARPRPSTD
VKSQTREKVY KCETCGKTYG WSSSLHKHER KHTGEKPVNA ASVGKPSGGL CSSKNVRTQI
GQKPSKCEKC GKAFSCPKAF QGHVRSHTGK KSCTSK
