ZN557_HUMAN
ID ZN557_HUMAN Reviewed; 423 AA.
AC Q8N988; Q6PEJ3; Q9BTZ1;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2005, sequence version 2.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Zinc finger protein 557;
GN Name=ZNF557;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-368 (ISOFORM 2).
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8N988-2; P54253: ATXN1; NbExp=3; IntAct=EBI-10699005, EBI-930964;
CC Q8N988-2; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-10699005, EBI-11977221;
CC Q8N988-2; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10699005, EBI-748961;
CC Q8N988-2; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-10699005, EBI-5916454;
CC Q8N988-2; P42858: HTT; NbExp=12; IntAct=EBI-10699005, EBI-466029;
CC Q8N988-2; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-10699005, EBI-11522433;
CC Q8N988-2; P37840: SNCA; NbExp=3; IntAct=EBI-10699005, EBI-985879;
CC Q8N988-2; Q16623: STX1A; NbExp=3; IntAct=EBI-10699005, EBI-712466;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N988-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N988-2; Sequence=VSP_014515;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH58040.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305};
CC Sequence=BAC04567.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK095524; BAC04567.1; ALT_SEQ; mRNA.
DR EMBL; BC003020; AAH03020.1; -; mRNA.
DR EMBL; BC058040; AAH58040.1; ALT_SEQ; mRNA.
DR CCDS; CCDS42485.1; -. [Q8N988-2]
DR CCDS; CCDS45945.1; -. [Q8N988-1]
DR RefSeq; NP_001037852.1; NM_001044387.1. [Q8N988-2]
DR RefSeq; NP_001037853.1; NM_001044388.1. [Q8N988-1]
DR RefSeq; NP_077317.2; NM_024341.2. [Q8N988-2]
DR AlphaFoldDB; Q8N988; -.
DR SMR; Q8N988; -.
DR BioGRID; 122606; 16.
DR IntAct; Q8N988; 13.
DR MINT; Q8N988; -.
DR STRING; 9606.ENSP00000252840; -.
DR iPTMnet; Q8N988; -.
DR PhosphoSitePlus; Q8N988; -.
DR BioMuta; ZNF557; -.
DR DMDM; 68566211; -.
DR EPD; Q8N988; -.
DR jPOST; Q8N988; -.
DR MassIVE; Q8N988; -.
DR MaxQB; Q8N988; -.
DR PaxDb; Q8N988; -.
DR PeptideAtlas; Q8N988; -.
DR PRIDE; Q8N988; -.
DR ProteomicsDB; 72505; -. [Q8N988-1]
DR ProteomicsDB; 72506; -. [Q8N988-2]
DR Antibodypedia; 6429; 95 antibodies from 19 providers.
DR DNASU; 79230; -.
DR Ensembl; ENST00000252840.11; ENSP00000252840.5; ENSG00000130544.12. [Q8N988-2]
DR Ensembl; ENST00000414706.2; ENSP00000404065.2; ENSG00000130544.12. [Q8N988-1]
DR GeneID; 79230; -.
DR KEGG; hsa:79230; -.
DR MANE-Select; ENST00000252840.11; ENSP00000252840.5; NM_024341.3; NP_077317.2. [Q8N988-2]
DR UCSC; uc002mga.4; human. [Q8N988-1]
DR CTD; 79230; -.
DR GeneCards; ZNF557; -.
DR HGNC; HGNC:28632; ZNF557.
DR HPA; ENSG00000130544; Low tissue specificity.
DR neXtProt; NX_Q8N988; -.
DR OpenTargets; ENSG00000130544; -.
DR PharmGKB; PA134866521; -.
DR VEuPathDB; HostDB:ENSG00000130544; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160844; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; Q8N988; -.
DR OMA; EFNECNQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N988; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q8N988; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N988; -.
DR BioGRID-ORCS; 79230; 12 hits in 1096 CRISPR screens.
DR GenomeRNAi; 79230; -.
DR Pharos; Q8N988; Tdark.
DR PRO; PR:Q8N988; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N988; protein.
DR Bgee; ENSG00000130544; Expressed in calcaneal tendon and 112 other tissues.
DR Genevisible; Q8N988; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 6.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..423
FT /note="Zinc finger protein 557"
FT /id="PRO_0000047647"
FT DOMAIN 36..107
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 145..167
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..195
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 201..223
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 229..251
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 257..279
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 285..307
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 313..335
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 341..363
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 369..391
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 397..419
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 11
FT /note="A -> ALSSLFPA (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_014515"
SQ SEQUENCE 423 AA; 48627 MW; B9B98806E91AFD85 CRC64;
MAAVVLPPTA ASQREGHTEG GELVNELLKS WLKGLVTFED VAVEFTQEEW ALLDPAQRTL
YRDVMLENCR NLASLGNQVD KPRLISQLEQ EDKVMTEERG ILSGTCPDVE NPFKAKGLTP
KLHVFRKEQS RNMKMERNHL GATLNECNQC FKVFSTKSSL TRHRKIHTGE RPYGCSECGK
SYSSRSYLAV HKRIHNGEKP YECNDCGKTF SSRSYLTVHK RIHNGEKPYE CSDCGKTFSN
SSYLRPHLRI HTGEKPYKCN QCFREFRTQS IFTRHKRVHT GEGHYVCNQC GKAFGTRSSL
SSHYSIHTGE YPYECHDCGR TFRRRSNLTQ HIRTHTGEKP YTCNECGKSF TNSFSLTIHR
RIHNGEKSYE CSDCGKSFNV LSSVKKHMRT HTGKKPYECN YCGKSFTSNS YLSVHTRMHN
RQM
