ZN558_HUMAN
ID ZN558_HUMAN Reviewed; 402 AA.
AC Q96NG5; A8K5F0; B7Z798;
DT 05-JUL-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 160.
DE RecName: Full=Zinc finger protein 558;
GN Name=ZNF558;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Brain, and Esophagus;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Cervix;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96NG5; P49760: CLK2; NbExp=3; IntAct=EBI-373363, EBI-750020;
CC Q96NG5; P68400: CSNK2A1; NbExp=3; IntAct=EBI-373363, EBI-347804;
CC Q96NG5; O95967: EFEMP2; NbExp=3; IntAct=EBI-373363, EBI-743414;
CC Q96NG5; Q8N9N8: EIF1AD; NbExp=3; IntAct=EBI-373363, EBI-750700;
CC Q96NG5; P57764: GSDMD; NbExp=3; IntAct=EBI-373363, EBI-2798865;
CC Q96NG5; Q96MH2: HEXIM2; NbExp=3; IntAct=EBI-373363, EBI-5460660;
CC Q96NG5; Q8WZA0: LZIC; NbExp=3; IntAct=EBI-373363, EBI-5774346;
CC Q96NG5; Q9UI95: MAD2L2; NbExp=3; IntAct=EBI-373363, EBI-77889;
CC Q96NG5; P55081: MFAP1; NbExp=3; IntAct=EBI-373363, EBI-1048159;
CC Q96NG5; P0CB47: UBTFL1; NbExp=3; IntAct=EBI-373363, EBI-17208936;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96NG5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96NG5-2; Sequence=VSP_055963;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK055494; BAB70934.1; -; mRNA.
DR EMBL; AK291265; BAF83954.1; -; mRNA.
DR EMBL; AK301664; BAH13534.1; -; mRNA.
DR EMBL; AC008734; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012616; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471106; EAW83994.1; -; Genomic_DNA.
DR EMBL; BC064356; AAH64356.1; -; mRNA.
DR CCDS; CCDS12208.1; -. [Q96NG5-1]
DR RefSeq; NP_001291279.1; NM_001304350.1. [Q96NG5-2]
DR RefSeq; NP_653294.1; NM_144693.2. [Q96NG5-1]
DR RefSeq; XP_011526005.1; XM_011527703.2. [Q96NG5-2]
DR RefSeq; XP_016881859.1; XM_017026370.1. [Q96NG5-2]
DR RefSeq; XP_016881860.1; XM_017026371.1. [Q96NG5-2]
DR RefSeq; XP_016881861.1; XM_017026372.1. [Q96NG5-2]
DR AlphaFoldDB; Q96NG5; -.
DR SMR; Q96NG5; -.
DR BioGRID; 127124; 25.
DR IntAct; Q96NG5; 16.
DR STRING; 9606.ENSP00000471277; -.
DR iPTMnet; Q96NG5; -.
DR PhosphoSitePlus; Q96NG5; -.
DR BioMuta; ZNF558; -.
DR DMDM; 68566225; -.
DR EPD; Q96NG5; -.
DR jPOST; Q96NG5; -.
DR MassIVE; Q96NG5; -.
DR MaxQB; Q96NG5; -.
DR PaxDb; Q96NG5; -.
DR PeptideAtlas; Q96NG5; -.
DR PRIDE; Q96NG5; -.
DR ProteomicsDB; 77510; -. [Q96NG5-1]
DR TopDownProteomics; Q96NG5-1; -. [Q96NG5-1]
DR Antibodypedia; 844; 105 antibodies from 18 providers.
DR DNASU; 148156; -.
DR Ensembl; ENST00000301475.1; ENSP00000301475.1; ENSG00000167785.9. [Q96NG5-1]
DR Ensembl; ENST00000601372.6; ENSP00000471277.1; ENSG00000167785.9. [Q96NG5-1]
DR GeneID; 148156; -.
DR KEGG; hsa:148156; -.
DR MANE-Select; ENST00000601372.6; ENSP00000471277.1; NM_144693.3; NP_653294.1.
DR UCSC; uc002mkn.1; human. [Q96NG5-1]
DR CTD; 148156; -.
DR GeneCards; ZNF558; -.
DR HGNC; HGNC:26422; ZNF558.
DR HPA; ENSG00000167785; Low tissue specificity.
DR neXtProt; NX_Q96NG5; -.
DR OpenTargets; ENSG00000167785; -.
DR PharmGKB; PA134899314; -.
DR VEuPathDB; HostDB:ENSG00000167785; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000160844; -.
DR HOGENOM; CLU_002678_44_17_1; -.
DR InParanoid; Q96NG5; -.
DR OMA; KINECNQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96NG5; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q96NG5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96NG5; -.
DR BioGRID-ORCS; 148156; 12 hits in 1096 CRISPR screens.
DR ChiTaRS; ZNF558; human.
DR GenomeRNAi; 148156; -.
DR Pharos; Q96NG5; Tdark.
DR PRO; PR:Q96NG5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96NG5; protein.
DR Bgee; ENSG00000167785; Expressed in body of uterus and 161 other tissues.
DR Genevisible; Q96NG5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 9.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..402
FT /note="Zinc finger protein 558"
FT /id="PRO_0000047648"
FT DOMAIN 43..114
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 152..174
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 180..202
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 208..230
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 236..258
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 264..286
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 292..314
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 320..342
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..71
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_055963"
SQ SEQUENCE 402 AA; 45755 MW; BB77228C89FBDD61 CRC64;
MAAVILPSTA APSSLFPASQ QKGHTQGGEL VNELLTSWLR GLVTFEDVAV EFTQEEWALL
DPAQRTLYRD VMLENCRNLA SLGCRVNKPS LISQLEQDKK VVTEERGILP STCPDLETLL
KAKWLTPKKN VFRKEQSKGV KTERSHRGVK LNECNQCFKV FSTKSNLTQH KRIHTGEKPY
DCSQCGKSFS SRSYLTIHKR IHNGEKPYEC NHCGKAFSDP SSLRLHLRIH TGEKPYECNQ
CFHVFRTSCN LKSHKRIHTG ENHHECNQCG KAFSTRSSLT GHNSIHTGEK PYECHDCGKT
FRKSSYLTQH VRTHTGEKPY ECNECGKSFS SSFSLTVHKR IHTGEKPYEC SDCGKAFNNL
SAVKKHLRTH TGEKPYECNH CGKSFTSNSY LSVHKRIHNR WI
