ZN559_HUMAN
ID ZN559_HUMAN Reviewed; 538 AA.
AC Q9BR84; K7EMG6;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 167.
DE RecName: Full=Zinc finger protein 559;
GN Name=ZNF559;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9BR84; Q9NP86: CABP5; NbExp=3; IntAct=EBI-746605, EBI-10311131;
CC Q9BR84; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-746605, EBI-3866279;
CC Q9BR84; P60370: KRTAP10-5; NbExp=4; IntAct=EBI-746605, EBI-10172150;
CC Q9BR84; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-746605, EBI-10171774;
CC Q9BR84; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-746605, EBI-10172511;
CC Q9BR84; P45984: MAPK9; NbExp=3; IntAct=EBI-746605, EBI-713568;
CC Q9BR84; Q99750: MDFI; NbExp=8; IntAct=EBI-746605, EBI-724076;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BR84-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BR84-2; Sequence=VSP_047039, VSP_047040;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK027700; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AC011451; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC006436; AAH06436.1; -; mRNA.
DR CCDS; CCDS12211.1; -. [Q9BR84-1]
DR CCDS; CCDS59349.1; -. [Q9BR84-2]
DR RefSeq; NP_001189339.1; NM_001202410.1. [Q9BR84-2]
DR RefSeq; NP_001189341.1; NM_001202412.1. [Q9BR84-2]
DR RefSeq; NP_115886.1; NM_032497.2. [Q9BR84-1]
DR AlphaFoldDB; Q9BR84; -.
DR SMR; Q9BR84; -.
DR BioGRID; 124118; 11.
DR IntAct; Q9BR84; 9.
DR STRING; 9606.ENSP00000468153; -.
DR iPTMnet; Q9BR84; -.
DR PhosphoSitePlus; Q9BR84; -.
DR BioMuta; ZNF559; -.
DR DMDM; 74762704; -.
DR EPD; Q9BR84; -.
DR jPOST; Q9BR84; -.
DR MassIVE; Q9BR84; -.
DR MaxQB; Q9BR84; -.
DR PaxDb; Q9BR84; -.
DR PeptideAtlas; Q9BR84; -.
DR PRIDE; Q9BR84; -.
DR Antibodypedia; 12574; 120 antibodies from 17 providers.
DR DNASU; 84527; -.
DR Ensembl; ENST00000317221.11; ENSP00000325393.7; ENSG00000188321.14. [Q9BR84-2]
DR Ensembl; ENST00000393883.6; ENSP00000377461.1; ENSG00000188321.14. [Q9BR84-1]
DR Ensembl; ENST00000585352.5; ENSP00000467048.1; ENSG00000188321.14. [Q9BR84-2]
DR Ensembl; ENST00000603380.6; ENSP00000474760.1; ENSG00000188321.14. [Q9BR84-1]
DR GeneID; 84527; -.
DR KEGG; hsa:84527; -.
DR MANE-Select; ENST00000603380.6; ENSP00000474760.1; NM_032497.3; NP_115886.1.
DR UCSC; uc002mlf.4; human. [Q9BR84-1]
DR CTD; 84527; -.
DR DisGeNET; 84527; -.
DR GeneCards; ZNF559; -.
DR HGNC; HGNC:28197; ZNF559.
DR HPA; ENSG00000188321; Low tissue specificity.
DR neXtProt; NX_Q9BR84; -.
DR OpenTargets; ENSG00000188321; -.
DR PharmGKB; PA134891126; -.
DR VEuPathDB; HostDB:ENSG00000188321; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164004; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q9BR84; -.
DR OMA; QDGEKFC; -.
DR PhylomeDB; Q9BR84; -.
DR PathwayCommons; Q9BR84; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9BR84; -.
DR BioGRID-ORCS; 84527; 420 hits in 1092 CRISPR screens.
DR ChiTaRS; ZNF559; human.
DR GenomeRNAi; 84527; -.
DR Pharos; Q9BR84; Tdark.
DR PRO; PR:Q9BR84; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BR84; protein.
DR Bgee; ENSG00000188321; Expressed in secondary oocyte and 170 other tissues.
DR ExpressionAtlas; Q9BR84; baseline and differential.
DR Genevisible; Q9BR84; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 8.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 9.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 11.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..538
FT /note="Zinc finger protein 559"
FT /id="PRO_0000047649"
FT DOMAIN 14..89
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 91..113
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 119..141
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 147..179
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 185..207
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 241..263
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 325..347
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 353..375
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 381..403
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 409..431
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 437..459
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 465..487
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 493..515
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 82..84
FT /note="ERN -> NSE (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047039"
FT VAR_SEQ 85..538
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_047040"
FT VARIANT 251
FT /note="T -> N (in dbSNP:rs16979670)"
FT /id="VAR_033576"
SQ SEQUENCE 538 AA; 62318 MW; C8BB5EB44B92034A CRC64;
MVAGWLTNYS QDSVTFEDVA VDFTQEEWTL LDQTQRNLYR DVMLENYKNL VAVDWESHIN
TKWSAPQQNF LQGKTSSVVE MERNHFGEEL FDFNQCEKAL SEHSCLKTHR RTYFRKKTCE
CNQCEKAFRK PSIFTLHKKT DIGEELPNCN QCETAFSQHL HLVCKKTSQN LHLVCKKTHT
QEKPYKCSDC EKGLPSSSHL RECVRIYGGE RPYTHKEYVE TFSHSTALFV HMQTQDGEKF
YECKACGKPF TESSYLTQHL RTHSRVLPIE HKKFGKAFAF SPDLAKHIRL RTRGKHYVCN
ECGKEFTCFS KLNIHIRVHT GEKPYECNKC GKAFTDSSGL IKHRRTHTGE KPYECKECGK
AFANSSHLTV HMRTHTGEKP YQCKECGKAF INSSSFKSHM QTHPGVKPYD CQQCGKAFIR
SSFLIRHLRS HSAERPFECE ECGKAFRYSS HLSQHKRIHT GERPYKCQKC GQAFSISSGL
TVHMRTHTGE RPFECQECGK AFTRSTYLIR HLRSHSVEKP YKECGQTFSN SSCLTECV
