ZN560_HUMAN
ID ZN560_HUMAN Reviewed; 790 AA.
AC Q96MR9; Q495S9; Q495T1;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-MAY-2006, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 560;
GN Name=ZNF560;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP VARIANT [LARGE SCALE ANALYSIS] GLU-186.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK056548; BAB71213.1; -; mRNA.
DR EMBL; BC101040; AAI01041.1; -; mRNA.
DR EMBL; BC101041; AAI01042.1; -; mRNA.
DR EMBL; BC101042; AAI01043.1; -; mRNA.
DR CCDS; CCDS12214.1; -.
DR RefSeq; NP_689689.2; NM_152476.2.
DR RefSeq; XP_011525998.1; XM_011527696.2.
DR RefSeq; XP_011525999.1; XM_011527697.2.
DR RefSeq; XP_016881816.1; XM_017026327.1.
DR RefSeq; XP_016881817.1; XM_017026328.1.
DR RefSeq; XP_016881818.1; XM_017026329.1.
DR AlphaFoldDB; Q96MR9; -.
DR SMR; Q96MR9; -.
DR STRING; 9606.ENSP00000301480; -.
DR iPTMnet; Q96MR9; -.
DR PhosphoSitePlus; Q96MR9; -.
DR BioMuta; ZNF560; -.
DR DMDM; 97219157; -.
DR EPD; Q96MR9; -.
DR jPOST; Q96MR9; -.
DR MassIVE; Q96MR9; -.
DR PaxDb; Q96MR9; -.
DR PeptideAtlas; Q96MR9; -.
DR PRIDE; Q96MR9; -.
DR ProteomicsDB; 77391; -.
DR Antibodypedia; 25042; 74 antibodies from 16 providers.
DR DNASU; 147741; -.
DR Ensembl; ENST00000301480.5; ENSP00000301480.3; ENSG00000198028.4.
DR GeneID; 147741; -.
DR KEGG; hsa:147741; -.
DR MANE-Select; ENST00000301480.5; ENSP00000301480.3; NM_152476.3; NP_689689.2.
DR UCSC; uc002mlp.2; human.
DR CTD; 147741; -.
DR DisGeNET; 147741; -.
DR GeneCards; ZNF560; -.
DR HGNC; HGNC:26484; ZNF560.
DR HPA; ENSG00000198028; Group enriched (retina, testis).
DR neXtProt; NX_Q96MR9; -.
DR OpenTargets; ENSG00000198028; -.
DR PharmGKB; PA134992071; -.
DR VEuPathDB; HostDB:ENSG00000198028; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164683; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q96MR9; -.
DR OMA; RNSLCFH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96MR9; -.
DR TreeFam; TF342172; -.
DR PathwayCommons; Q96MR9; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 147741; 11 hits in 1094 CRISPR screens.
DR ChiTaRS; ZNF560; human.
DR GenomeRNAi; 147741; -.
DR Pharos; Q96MR9; Tdark.
DR PRO; PR:Q96MR9; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96MR9; protein.
DR Bgee; ENSG00000198028; Expressed in right testis and 50 other tissues.
DR Genevisible; Q96MR9; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0001227; F:DNA-binding transcription repressor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 2.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 2.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 2.
DR SMART; SM00355; ZnF_C2H2; 14.
DR SUPFAM; SSF109640; SSF109640; 2.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 14.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..790
FT /note="Zinc finger protein 560"
FT /id="PRO_0000234589"
FT DOMAIN 13..84
FT /note="KRAB 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT DOMAIN 110..181
FT /note="KRAB 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 284..314
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 348..370
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 376..398
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 404..426
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 432..454
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 488..510
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 516..538
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 544..566
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 572..594
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 600..622
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 628..650
FT /note="C2H2-type 11; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 656..678
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 712..734
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 740..762
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 768..790
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 186
FT /note="G -> E (in a colorectal cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035588"
FT VARIANT 630
FT /note="Y -> C (in dbSNP:rs10416098)"
FT /id="VAR_052866"
FT CONFLICT 475
FT /note="V -> I (in Ref. 1; BAB71213)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 790 AA; 91121 MW; 9434B9F290621036 CRC64;
MAYCLTNCYQ YSVTFEDTAV DFTQEEWILL DPVQRNLYRD VMLENYENVA KVGFQLFKPS
VISWLEEEEL RTLQQGVLQD WAIKHQTSVS ALQQEFWKIQ TSNGIQMDLV TFDSVAVEFT
QEEWTLLDPA QRNLYSDVML ENYKNLSSVG YQLFKPSLIS WLEEEEELST LPRVLQEWKM
CLKTKGPALW QDNFCLKTLN GIQLARNQNG EELYDCKQCE DVFCKHPCLK TNMSTQNRGN
TSECIQYAKD LLSLYNKTST IRKVSVFSKH GKSFRLILNV QVQRKCTQDK SFEGTDYGKA
FIYQSYLEAH RKTQSGEKLN EWKQCGEAFT HSTSHAVNVE THIIKNPYEC KECGKDFRYP
THLNNHMQTH IGIKPYKCKH CGKTFTVPSG FLEHVRTHTG EKPYGCKECG KAFGTSAGLI
EHIRCHAREK TFKCDHCGKA FISYPSLFGH LRVHNGEKPY EHKEYGKAFG TSSGVIEDRR
SNTGQKRFDC DQCGKVFVSF SSLFAHLRTH TGEKPFKCYK CGKPFTSSAC LRIHMRTHTE
ERLYQCKKCG KAFTKCSYLT KHLRTHAGEK PYECMKCGKA FTERSYLTKH LRRHSGEKPY
ECKKCGKAFT ERSDLTKHLR RHTGDKPYEY KDCGKAFVVS SSLVDHLRTH TGYKPYKCNA
CEKAYSRSCV LTQHLKTHAA EKTSECNACG NSFRNSMCFH DRLKTLTKIK PYKCKDCGKA
FTCHSDLTNH VRIHTGEKPY KCKECGKAFR TSSGRIQHLR THMGEKPFEC DQCGKAFASF
SARIAHLKTH
