ZN562_HUMAN
ID ZN562_HUMAN Reviewed; 426 AA.
AC Q6V9R5; Q32MN2; Q9NXS5;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-2007, sequence version 2.
DT 03-AUG-2022, entry version 150.
DE RecName: Full=Zinc finger protein 562;
GN Name=ZNF562;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANTS LEU-178
RP AND GLU-205.
RC TISSUE=Colon;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RA Zhou G., Yu R., Cao L., Ke R., Li H., Shen C., Zhong G., Lin L., Yang S.;
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6V9R5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6V9R5-2; Sequence=VSP_016379, VSP_016380;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK000086; BAA90935.1; -; mRNA.
DR EMBL; AY346375; AAQ54330.1; -; mRNA.
DR EMBL; CH471106; EAW84044.1; -; Genomic_DNA.
DR EMBL; BC109062; AAI09063.2; -; mRNA.
DR CCDS; CCDS12217.1; -. [Q6V9R5-2]
DR CCDS; CCDS45956.1; -. [Q6V9R5-1]
DR RefSeq; NP_001123503.1; NM_001130031.1. [Q6V9R5-1]
DR RefSeq; NP_001123504.1; NM_001130032.1. [Q6V9R5-1]
DR RefSeq; NP_001287814.1; NM_001300885.1.
DR RefSeq; NP_060126.2; NM_017656.3. [Q6V9R5-2]
DR RefSeq; XP_005259998.1; XM_005259941.3. [Q6V9R5-1]
DR AlphaFoldDB; Q6V9R5; -.
DR SMR; Q6V9R5; -.
DR BioGRID; 120168; 20.
DR IntAct; Q6V9R5; 10.
DR STRING; 9606.ENSP00000410734; -.
DR iPTMnet; Q6V9R5; -.
DR PhosphoSitePlus; Q6V9R5; -.
DR BioMuta; ZNF562; -.
DR DMDM; 146291105; -.
DR EPD; Q6V9R5; -.
DR MassIVE; Q6V9R5; -.
DR MaxQB; Q6V9R5; -.
DR PaxDb; Q6V9R5; -.
DR PeptideAtlas; Q6V9R5; -.
DR PRIDE; Q6V9R5; -.
DR ProteomicsDB; 67719; -. [Q6V9R5-1]
DR ProteomicsDB; 67720; -. [Q6V9R5-2]
DR Antibodypedia; 25073; 119 antibodies from 18 providers.
DR DNASU; 54811; -.
DR Ensembl; ENST00000293648.8; ENSP00000293648.3; ENSG00000171466.10. [Q6V9R5-2]
DR Ensembl; ENST00000453372.7; ENSP00000410734.1; ENSG00000171466.10. [Q6V9R5-1]
DR GeneID; 54811; -.
DR KEGG; hsa:54811; -.
DR MANE-Select; ENST00000453372.7; ENSP00000410734.1; NM_001130031.2; NP_001123503.1.
DR UCSC; uc002mlx.4; human. [Q6V9R5-1]
DR CTD; 54811; -.
DR DisGeNET; 54811; -.
DR GeneCards; ZNF562; -.
DR HGNC; HGNC:25950; ZNF562.
DR HPA; ENSG00000171466; Low tissue specificity.
DR neXtProt; NX_Q6V9R5; -.
DR OpenTargets; ENSG00000171466; -.
DR PharmGKB; PA134941707; -.
DR VEuPathDB; HostDB:ENSG00000171466; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162984; -.
DR HOGENOM; CLU_002678_2_2_1; -.
DR InParanoid; Q6V9R5; -.
DR OMA; YYECKDM; -.
DR PhylomeDB; Q6V9R5; -.
DR TreeFam; TF341966; -.
DR PathwayCommons; Q6V9R5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6V9R5; -.
DR BioGRID-ORCS; 54811; 13 hits in 1097 CRISPR screens.
DR ChiTaRS; ZNF562; human.
DR GenomeRNAi; 54811; -.
DR Pharos; Q6V9R5; Tdark.
DR PRO; PR:Q6V9R5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6V9R5; protein.
DR Bgee; ENSG00000171466; Expressed in buccal mucosa cell and 201 other tissues.
DR ExpressionAtlas; Q6V9R5; baseline and differential.
DR Genevisible; Q6V9R5; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 9.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..426
FT /note="Zinc finger protein 562"
FT /id="PRO_0000047652"
FT DOMAIN 41..120
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 176..198
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 204..226
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..72
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016379"
FT VAR_SEQ 73..80
FT /note="NYMNLASV -> MSAFDMSH (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016380"
FT VARIANT 178
FT /note="F -> L (in dbSNP:rs1163497365)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_023936"
FT VARIANT 205
FT /note="K -> E (in dbSNP:rs1059199)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_023937"
FT VARIANT 260
FT /note="E -> K (in dbSNP:rs1059199)"
FT /id="VAR_059922"
FT CONFLICT 237
FT /note="C -> Y (in Ref. 2; AAQ54330)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="V -> I (in Ref. 2; AAQ54330)"
FT /evidence="ECO:0000305"
FT CONFLICT 379
FT /note="K -> R (in Ref. 1; BAA90935)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 426 AA; 48563 MW; CB285FD3A92C1C14 CRC64;
MSAFDMSHGF FPREPICPFE EKTKIGTMVE DHRSNSYQDS VTFDDVAVEF TPEEWALLDT
TQKYLYRDVM LENYMNLASV DFFFCLTSEW EIQPRTKRSS LQQGFLKNQI FTGIQMQTRS
YSGWKLCENC GEVFSEQFCL KTHMRAQNGG NTFEGNCYGK DSISVHKEAS IGQELSKFNP
CGKVFTLTPG LAVHLEILNG RQPYKCKECG KGFKYFASLD NHMGIHIGEK LCEFQECERA
ITTSSHLKQC VAVHTGKKSE KTKNCGKSFT NFSQLSAHAK THKGEKSFEC KECGRSFRNS
SSFNVHIQIH TGIKPHKCTE CGKAFTRSTH LTQHVRTHTG IKPYECKECG QAFTQYTGLA
IHIRNHTGEK PYQCKECGKA FNRSSTLTQH RRIHTGEKPY ECVECGKTFI TSSHRSKHLK
THSGER
