ZN563_HUMAN
ID ZN563_HUMAN Reviewed; 476 AA.
AC Q8TA94; B2R9E7; Q8NAT7;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein 563;
GN Name=ZNF563;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Spleen;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8TA94; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-11792334, EBI-12012928;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8TA94-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8TA94-2; Sequence=VSP_016381, VSP_016382;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK092116; BAC03810.1; -; mRNA.
DR EMBL; AK313755; BAG36494.1; -; mRNA.
DR EMBL; CH471106; EAW84268.1; -; Genomic_DNA.
DR EMBL; BC022523; AAH22523.1; -; mRNA.
DR CCDS; CCDS12270.1; -. [Q8TA94-1]
DR RefSeq; NP_660319.1; NM_145276.2. [Q8TA94-1]
DR RefSeq; XP_005259808.1; XM_005259751.3.
DR AlphaFoldDB; Q8TA94; -.
DR SMR; Q8TA94; -.
DR BioGRID; 127092; 34.
DR IntAct; Q8TA94; 10.
DR MINT; Q8TA94; -.
DR STRING; 9606.ENSP00000293725; -.
DR iPTMnet; Q8TA94; -.
DR PhosphoSitePlus; Q8TA94; -.
DR BioMuta; ZNF563; -.
DR DMDM; 74762598; -.
DR jPOST; Q8TA94; -.
DR MassIVE; Q8TA94; -.
DR MaxQB; Q8TA94; -.
DR PaxDb; Q8TA94; -.
DR PeptideAtlas; Q8TA94; -.
DR PRIDE; Q8TA94; -.
DR ProteomicsDB; 73841; -. [Q8TA94-1]
DR ProteomicsDB; 73842; -. [Q8TA94-2]
DR Antibodypedia; 26035; 119 antibodies from 16 providers.
DR DNASU; 147837; -.
DR Ensembl; ENST00000293725.10; ENSP00000293725.5; ENSG00000188868.14. [Q8TA94-1]
DR GeneID; 147837; -.
DR KEGG; hsa:147837; -.
DR MANE-Select; ENST00000293725.10; ENSP00000293725.5; NM_145276.3; NP_660319.1.
DR UCSC; uc002mtp.4; human. [Q8TA94-1]
DR CTD; 147837; -.
DR DisGeNET; 147837; -.
DR GeneCards; ZNF563; -.
DR HGNC; HGNC:30498; ZNF563.
DR HPA; ENSG00000188868; Tissue enhanced (testis).
DR neXtProt; NX_Q8TA94; -.
DR OpenTargets; ENSG00000188868; -.
DR PharmGKB; PA134949077; -.
DR VEuPathDB; HostDB:ENSG00000188868; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00950000182755; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8TA94; -.
DR OMA; KTFHHLG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TA94; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q8TA94; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TA94; -.
DR BioGRID-ORCS; 147837; 8 hits in 1092 CRISPR screens.
DR ChiTaRS; ZNF563; human.
DR GenomeRNAi; 147837; -.
DR Pharos; Q8TA94; Tdark.
DR PRO; PR:Q8TA94; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TA94; protein.
DR Bgee; ENSG00000188868; Expressed in left testis and 107 other tissues.
DR ExpressionAtlas; Q8TA94; baseline and differential.
DR Genevisible; Q8TA94; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 9.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 11.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..476
FT /note="Zinc finger protein 563"
FT /id="PRO_0000047653"
FT DOMAIN 4..96
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 101..125
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 199..229
FT /note="CKLCGKAFFWPSLLRMHERTHTGEKPYECKQ -> FPIEDMRECTLGRNRMN
FT VSSVLKPCLIPVP (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016381"
FT VAR_SEQ 230..476
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_016382"
SQ SEQUENCE 476 AA; 55434 MW; 02F71928C37166B2 CRC64;
MDAVAFEDVA VNFTQEEWAL LGPSQKNLYR YVMQETIRNL DCIRMIWEEQ NTEDQYKNPR
RNLRCHMVER FSESKDSSQC GETFSLIRDS IVNNSICPGE DPCQSAECEE VIMGHLSLNS
HIRVDSGHKP HEYQEYGEKP HTHKQRGKAF SYHHSFQSRG RPHTGKKRYE CKECGKTFSS
RRNLRRHMVV QGGNRPYKCK LCGKAFFWPS LLRMHERTHT GEKPYECKQC SKAFPFYSSY
RRHERMHTGE KPYECKQCSK ALPDSSSYIR HERTHTGEKP YTCKQCGKAF SVSSSLRRHE
TTHSAEKPYE CKQCGKTFHH LGSFQIHMKR HTGDRPHKCK ICGKGFDRPS LVRYHERIHT
GEKPYECKQC GKTLSHSSSF RRHMIMHTGG GPHKCKICGK AFVYPSVCQR HEKSHSGEKP
YECKQCGKAL SHSSSFRRHM VMHTGDGPNK CKVCGKAFVY PSVCQRHEKT HWRETI
