ZN564_HUMAN
ID ZN564_HUMAN Reviewed; 553 AA.
AC Q8TBZ8; B9EGT4; Q6P1K6;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2002, sequence version 1.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 564;
GN Name=ZNF564;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain, and Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-438, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=25218447; DOI=10.1038/nsmb.2890;
RA Hendriks I.A., D'Souza R.C., Yang B., Verlaan-de Vries M., Mann M.,
RA Vertegaal A.C.;
RT "Uncovering global SUMOylation signaling networks in a site-specific
RT manner.";
RL Nat. Struct. Mol. Biol. 21:927-936(2014).
RN [4]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-438, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q8TBZ8; P13196: ALAS1; NbExp=6; IntAct=EBI-10273713, EBI-3905054;
CC Q8TBZ8; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-10273713, EBI-739580;
CC Q8TBZ8; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-10273713, EBI-3866279;
CC Q8TBZ8; Q8NA61: CBY2; NbExp=3; IntAct=EBI-10273713, EBI-741724;
CC Q8TBZ8; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-10273713, EBI-11524851;
CC Q8TBZ8; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-10273713, EBI-11977221;
CC Q8TBZ8; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-10273713, EBI-10171416;
CC Q8TBZ8; Q15834: CCDC85B; NbExp=3; IntAct=EBI-10273713, EBI-739674;
CC Q8TBZ8; O95273: CCNDBP1; NbExp=3; IntAct=EBI-10273713, EBI-748961;
CC Q8TBZ8; Q5TD97: FHL5; NbExp=3; IntAct=EBI-10273713, EBI-750641;
CC Q8TBZ8; Q2TAP0: GOLGA7B; NbExp=3; IntAct=EBI-10273713, EBI-13310443;
CC Q8TBZ8; Q9HD26: GOPC; NbExp=3; IntAct=EBI-10273713, EBI-349832;
CC Q8TBZ8; O75031: HSF2BP; NbExp=3; IntAct=EBI-10273713, EBI-7116203;
CC Q8TBZ8; Q15323: KRT31; NbExp=3; IntAct=EBI-10273713, EBI-948001;
CC Q8TBZ8; Q6A162: KRT40; NbExp=3; IntAct=EBI-10273713, EBI-10171697;
CC Q8TBZ8; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-10273713, EBI-10172290;
CC Q8TBZ8; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-10273713, EBI-10172052;
CC Q8TBZ8; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-10273713, EBI-14065470;
CC Q8TBZ8; O95751: LDOC1; NbExp=3; IntAct=EBI-10273713, EBI-740738;
CC Q8TBZ8; P48059-3: LIMS1; NbExp=3; IntAct=EBI-10273713, EBI-12864460;
CC Q8TBZ8; P02545: LMNA; NbExp=3; IntAct=EBI-10273713, EBI-351935;
CC Q8TBZ8; P43355: MAGEA1; NbExp=4; IntAct=EBI-10273713, EBI-740978;
CC Q8TBZ8; Q99750: MDFI; NbExp=6; IntAct=EBI-10273713, EBI-724076;
CC Q8TBZ8; P50222: MEOX2; NbExp=3; IntAct=EBI-10273713, EBI-748397;
CC Q8TBZ8; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-10273713, EBI-10172526;
CC Q8TBZ8; Q5JR59-3: MTUS2; NbExp=4; IntAct=EBI-10273713, EBI-11522433;
CC Q8TBZ8; P17568: NDUFB7; NbExp=3; IntAct=EBI-10273713, EBI-1246238;
CC Q8TBZ8; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-10273713, EBI-2876622;
CC Q8TBZ8; Q8ND90: PNMA1; NbExp=3; IntAct=EBI-10273713, EBI-302345;
CC Q8TBZ8; Q96T49: PPP1R16B; NbExp=4; IntAct=EBI-10273713, EBI-10293968;
CC Q8TBZ8; Q04864: REL; NbExp=3; IntAct=EBI-10273713, EBI-307352;
CC Q8TBZ8; Q96KN7: RPGRIP1; NbExp=3; IntAct=EBI-10273713, EBI-1050213;
CC Q8TBZ8; O75478: TADA2A; NbExp=3; IntAct=EBI-10273713, EBI-742268;
CC Q8TBZ8; Q13077: TRAF1; NbExp=6; IntAct=EBI-10273713, EBI-359224;
CC Q8TBZ8; P36406: TRIM23; NbExp=6; IntAct=EBI-10273713, EBI-740098;
CC Q8TBZ8; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-10273713, EBI-725997;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH28367.2; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; AK092760; BAC03967.1; -; mRNA.
DR EMBL; BC028367; AAH28367.2; ALT_INIT; mRNA.
DR EMBL; BC065023; AAH65023.2; -; mRNA.
DR EMBL; BC136728; AAI36729.1; -; mRNA.
DR EMBL; BC136729; AAI36730.1; -; mRNA.
DR CCDS; CCDS42505.1; -.
DR RefSeq; NP_659413.1; NM_144976.3.
DR AlphaFoldDB; Q8TBZ8; -.
DR SMR; Q8TBZ8; -.
DR BioGRID; 127844; 44.
DR IntAct; Q8TBZ8; 38.
DR STRING; 9606.ENSP00000340004; -.
DR iPTMnet; Q8TBZ8; -.
DR PhosphoSitePlus; Q8TBZ8; -.
DR BioMuta; ZNF564; -.
DR DMDM; 55976746; -.
DR EPD; Q8TBZ8; -.
DR jPOST; Q8TBZ8; -.
DR MassIVE; Q8TBZ8; -.
DR MaxQB; Q8TBZ8; -.
DR PaxDb; Q8TBZ8; -.
DR PeptideAtlas; Q8TBZ8; -.
DR PRIDE; Q8TBZ8; -.
DR ProteomicsDB; 74062; -.
DR Antibodypedia; 49445; 83 antibodies from 17 providers.
DR DNASU; 163050; -.
DR Ensembl; ENST00000339282.12; ENSP00000340004.6; ENSG00000249709.8.
DR GeneID; 163050; -.
DR KEGG; hsa:163050; -.
DR MANE-Select; ENST00000339282.12; ENSP00000340004.6; NM_144976.4; NP_659413.1.
DR UCSC; uc002mty.4; human.
DR CTD; 163050; -.
DR GeneCards; ZNF564; -.
DR HGNC; HGNC:31106; ZNF564.
DR HPA; ENSG00000249709; Low tissue specificity.
DR neXtProt; NX_Q8TBZ8; -.
DR PharmGKB; PA134876070; -.
DR VEuPathDB; HostDB:ENSG00000249709; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164420; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8TBZ8; -.
DR OMA; IRSHAGH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8TBZ8; -.
DR TreeFam; TF338854; -.
DR PathwayCommons; Q8TBZ8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8TBZ8; -.
DR BioGRID-ORCS; 163050; 8 hits in 1063 CRISPR screens.
DR ChiTaRS; ZNF564; human.
DR GenomeRNAi; 163050; -.
DR Pharos; Q8TBZ8; Tdark.
DR PRO; PR:Q8TBZ8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8TBZ8; protein.
DR Bgee; ENSG00000249709; Expressed in calcaneal tendon and 102 other tissues.
DR ExpressionAtlas; Q8TBZ8; baseline and differential.
DR Genevisible; Q8TBZ8; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 15.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 15.
PE 1: Evidence at protein level;
KW DNA-binding; Isopeptide bond; Metal-binding; Nucleus; Reference proteome;
KW Repeat; Transcription; Transcription regulation; Ubl conjugation; Zinc;
KW Zinc-finger.
FT CHAIN 1..553
FT /note="Zinc finger protein 564"
FT /id="PRO_0000047654"
FT DOMAIN 4..83
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 103..125
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 141..163
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 169..191
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 438
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:25218447,
FT ECO:0007744|PubMed:28112733"
SQ SEQUENCE 553 AA; 63735 MW; CE5DB6E5D47EE019 CRC64;
MDSVASEDVA VNFTLEEWAL LDPSQKKLYR DVMRETFRNL ACVGKKWEDQ SIEDWYKNQG
RILRNHMEEG LSESKEYDQC GEAFSQILNL NLNKKIPTIV RPCECSLCGK VFMHHSSLSR
HIRSHLGHKP YDYQEYGEKP YKCKQCGKAF SSCQSFRRHE RTHTGEKPYA CPECGKAFIS
LPSVRRHMIK HTGDGPYKCQ ECGKAFDRPS LFQIHERTHT GEKPYECQEC AKAFISLPSF
QRHMIRHTGD GPYKCQECGK AFDRPSLFRI HERTHTGEKP HECKQCGKAF ISFTNFQSHM
IRHTGDGPYK CKVCGRAFIF PSYVRKHERT HTGEKPYECN KCGKTFSSSS NVRTHERTHT
GEKPYECKEC GKAFISLPSV RRHMIKHTGD GPYKCQVCGR AFDCPSSFQI HERTHTGEKP
YECQVCGKAF ISLKRIRKHM ILHTGDGPYK CQVCGKAFDC PSSVRTHERT HTGEKPYECK
ECGKAFNYAS SIRIHERTHT GEKPYECKQC GKTFSYSSSF QRHERAHNGD KPYVKNVGKL
SFITQPSNTC ENE
