ZN565_HUMAN
ID ZN565_HUMAN Reviewed; 539 AA.
AC Q8N9K5; B3KQ35; Q6NUS2;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2014, sequence version 2.
DT 03-AUG-2022, entry version 157.
DE RecName: Full=Zinc finger protein 565;
GN Name=ZNF565;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT THR-228.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N9K5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N9K5-2; Sequence=VSP_055965;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK057290; BAG51897.1; -; mRNA.
DR EMBL; AK094310; BAC04328.1; -; mRNA.
DR EMBL; AC008848; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC012617; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC068453; AAH68453.1; -; mRNA.
DR CCDS; CCDS12491.1; -. [Q8N9K5-2]
DR RefSeq; NP_001035939.1; NM_001042474.2. [Q8N9K5-2]
DR RefSeq; NP_689690.3; NM_152477.4. [Q8N9K5-2]
DR RefSeq; XP_011524814.1; XM_011526512.2. [Q8N9K5-2]
DR RefSeq; XP_011524816.1; XM_011526514.2. [Q8N9K5-2]
DR RefSeq; XP_016881830.1; XM_017026341.1.
DR AlphaFoldDB; Q8N9K5; -.
DR SMR; Q8N9K5; -.
DR BioGRID; 127099; 1.
DR IntAct; Q8N9K5; 1.
DR STRING; 9606.ENSP00000306869; -.
DR iPTMnet; Q8N9K5; -.
DR PhosphoSitePlus; Q8N9K5; -.
DR BioMuta; ZNF565; -.
DR DMDM; 74760034; -.
DR jPOST; Q8N9K5; -.
DR MassIVE; Q8N9K5; -.
DR MaxQB; Q8N9K5; -.
DR PaxDb; Q8N9K5; -.
DR PeptideAtlas; Q8N9K5; -.
DR PRIDE; Q8N9K5; -.
DR ProteomicsDB; 72550; -. [Q8N9K5-1]
DR Antibodypedia; 29730; 79 antibodies from 14 providers.
DR DNASU; 147929; -.
DR Ensembl; ENST00000304116.10; ENSP00000306869.5; ENSG00000196357.12. [Q8N9K5-2]
DR Ensembl; ENST00000355114.9; ENSP00000347234.5; ENSG00000196357.12. [Q8N9K5-1]
DR Ensembl; ENST00000392173.6; ENSP00000376013.1; ENSG00000196357.12. [Q8N9K5-2]
DR GeneID; 147929; -.
DR KEGG; hsa:147929; -.
DR MANE-Select; ENST00000304116.10; ENSP00000306869.5; NM_152477.5; NP_689690.3. [Q8N9K5-2]
DR UCSC; uc002odn.4; human. [Q8N9K5-1]
DR CTD; 147929; -.
DR DisGeNET; 147929; -.
DR GeneCards; ZNF565; -.
DR HGNC; HGNC:26726; ZNF565.
DR HPA; ENSG00000196357; Low tissue specificity.
DR neXtProt; NX_Q8N9K5; -.
DR OpenTargets; ENSG00000196357; -.
DR PharmGKB; PA134970652; -.
DR VEuPathDB; HostDB:ENSG00000196357; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163001; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8N9K5; -.
DR OMA; NMPTFEH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N9K5; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q8N9K5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N9K5; -.
DR BioGRID-ORCS; 147929; 9 hits in 1094 CRISPR screens.
DR ChiTaRS; ZNF565; human.
DR GenomeRNAi; 147929; -.
DR Pharos; Q8N9K5; Tdark.
DR PRO; PR:Q8N9K5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N9K5; protein.
DR Bgee; ENSG00000196357; Expressed in buccal mucosa cell and 164 other tissues.
DR ExpressionAtlas; Q8N9K5; baseline and differential.
DR Genevisible; Q8N9K5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..539
FT /note="Zinc finger protein 565"
FT /id="PRO_0000047655"
FT DOMAIN 46..117
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 207..229
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..425
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..453
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 459..481
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 487..509
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 515..537
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..40
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_055965"
FT VARIANT 228
FT /note="I -> T (in dbSNP:rs4805162)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023938"
SQ SEQUENCE 539 AA; 62445 MW; CACB38F824A22856 CRC64;
MRRGPWERWS LASHRLDAGL CTCPREESRE IRAGQIVLKA MAQGLVTFRD VAIEFSLEEW
KCLEPAQRDL YREVTLENFG HLASLGLSIS KPDVVSLLEQ GKEPWMIAND VTGPWCPDLE
SRCEKFLQKD IFEIGAFNWE IMESLKCSDL EGSDFRADWE CEGQFERQVN EECYFKQVNV
TYGHMPVFQH HTSHTVRQSR ETGEKLMECH ECGKAFSRGS HLIQHQKIHT GEKPFGCKEC
GKAFSRASHL VQHQRIHTGE KPYDCKDCGK AFGRTSELIL HQRLHTGVKP YECKECGKTF
RQHSQLILHQ RTHTGEKPYV CKDCGKAFIR GSQLTVHRRI HTGARPYECK ECGKAFRQHS
QLTVHQRIHT GEKPYECKEC GKGFIHSSEV TRHQRIHSGE KPYECKECGK AFRQHAQLTR
HQRVHTGDRP YECKDCGKAF SRSSYLIQHQ RIHTGDKPYE CKECGKAFIR VSQLTHHQRI
HTCEKPYECR ECGMAFIRSS QLTEHQRIHP GIKPYECREC GQAFILGSQL IEHYRIHTG
