ZN569_HUMAN
ID ZN569_HUMAN Reviewed; 686 AA.
AC Q5MCW4; A8K1S2; Q15925; Q17RR6; Q96MQ2;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 148.
DE RecName: Full=Zinc finger protein 569;
GN Name=ZNF569;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
RX PubMed=16793018; DOI=10.1016/j.bbrc.2006.05.109;
RA Huang X., Yuan W., Huang W., Bai Y., Deng Y., Zhu C., Liang P., Li Y.,
RA Du X., Liu M., Wang Y., Wu X.;
RT "ZNF569, a novel KRAB-containing zinc finger protein, suppresses MAPK
RT signaling pathway.";
RL Biochem. Biophys. Res. Commun. 346:621-628(2006).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC TISSUE=Hippocampus, and Tongue;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Liver;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [6]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 207-263.
RC TISSUE=Placenta;
RX PubMed=1505991; DOI=10.1016/0888-7543(92)90013-i;
RA Lichter P., Bray P., Ried T., Dawid I.B., Ward D.C.;
RT "Clustering of C2-H2 zinc finger motif sequences within telomeric and
RT fragile site regions of human chromosomes.";
RL Genomics 13:999-1007(1992).
RN [7]
RP VARIANTS [LARGE SCALE ANALYSIS] GLU-29 AND GLY-87.
RX PubMed=16959974; DOI=10.1126/science.1133427;
RA Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D.,
RA Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P.,
RA Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V.,
RA Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H.,
RA Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W.,
RA Velculescu V.E.;
RT "The consensus coding sequences of human breast and colorectal cancers.";
RL Science 314:268-274(2006).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- INTERACTION:
CC Q5MCW4; Q15323: KRT31; NbExp=6; IntAct=EBI-4395687, EBI-948001;
CC Q5MCW4; Q6A162: KRT40; NbExp=3; IntAct=EBI-4395687, EBI-10171697;
CC Q5MCW4; P07101-3: TH; NbExp=3; IntAct=EBI-4395687, EBI-12001016;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q5MCW4-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q5MCW4-2; Sequence=VSP_055966;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AK056615; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY835704; AAV97944.1; -; mRNA.
DR EMBL; AK056615; -; NOT_ANNOTATED_CDS; mRNA.
DR EMBL; AK289987; BAF82676.1; -; mRNA.
DR EMBL; AC008806; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471126; EAW56728.1; -; Genomic_DNA.
DR EMBL; BC117219; AAI17220.1; -; mRNA.
DR EMBL; M88363; AAA61321.1; -; Genomic_DNA.
DR CCDS; CCDS12503.1; -. [Q5MCW4-1]
DR CCDS; CCDS82341.1; -. [Q5MCW4-2]
DR PIR; G43284; G43284.
DR RefSeq; NP_001317411.1; NM_001330482.1. [Q5MCW4-2]
DR RefSeq; NP_689697.2; NM_152484.2. [Q5MCW4-1]
DR RefSeq; XP_011524841.1; XM_011526539.2. [Q5MCW4-1]
DR RefSeq; XP_016881865.1; XM_017026376.1. [Q5MCW4-1]
DR RefSeq; XP_016881866.1; XM_017026377.1. [Q5MCW4-1]
DR RefSeq; XP_016881868.1; XM_017026379.1. [Q5MCW4-2]
DR RefSeq; XP_016881869.1; XM_017026380.1. [Q5MCW4-2]
DR RefSeq; XP_016881871.1; XM_017026382.1. [Q5MCW4-2]
DR AlphaFoldDB; Q5MCW4; -.
DR SMR; Q5MCW4; -.
DR BioGRID; 127137; 7.
DR IntAct; Q5MCW4; 6.
DR STRING; 9606.ENSP00000325018; -.
DR iPTMnet; Q5MCW4; -.
DR PhosphoSitePlus; Q5MCW4; -.
DR BioMuta; ZNF569; -.
DR DMDM; 74762209; -.
DR EPD; Q5MCW4; -.
DR jPOST; Q5MCW4; -.
DR MassIVE; Q5MCW4; -.
DR MaxQB; Q5MCW4; -.
DR PaxDb; Q5MCW4; -.
DR PeptideAtlas; Q5MCW4; -.
DR PRIDE; Q5MCW4; -.
DR ProteomicsDB; 61164; -.
DR ProteomicsDB; 63573; -. [Q5MCW4-1]
DR Antibodypedia; 44797; 93 antibodies from 15 providers.
DR DNASU; 148266; -.
DR Ensembl; ENST00000316950.11; ENSP00000325018.5; ENSG00000196437.12. [Q5MCW4-1]
DR Ensembl; ENST00000392149.6; ENSP00000375992.2; ENSG00000196437.12. [Q5MCW4-1]
DR Ensembl; ENST00000392150.2; ENSP00000375993.2; ENSG00000196437.12. [Q5MCW4-2]
DR GeneID; 148266; -.
DR KEGG; hsa:148266; -.
DR MANE-Select; ENST00000316950.11; ENSP00000325018.5; NM_152484.3; NP_689697.2.
DR UCSC; uc002ogh.4; human. [Q5MCW4-1]
DR CTD; 148266; -.
DR DisGeNET; 148266; -.
DR GeneCards; ZNF569; -.
DR HGNC; HGNC:24737; ZNF569.
DR HPA; ENSG00000196437; Low tissue specificity.
DR MIM; 613904; gene.
DR neXtProt; NX_Q5MCW4; -.
DR OpenTargets; ENSG00000196437; -.
DR PharmGKB; PA134899564; -.
DR VEuPathDB; HostDB:ENSG00000196437; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154650; -.
DR HOGENOM; CLU_002678_17_1_1; -.
DR InParanoid; Q5MCW4; -.
DR OMA; QSYECNE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q5MCW4; -.
DR PathwayCommons; Q5MCW4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q5MCW4; -.
DR BioGRID-ORCS; 148266; 19 hits in 1070 CRISPR screens.
DR ChiTaRS; ZNF569; human.
DR GenomeRNAi; 148266; -.
DR Pharos; Q5MCW4; Tbio.
DR PRO; PR:Q5MCW4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q5MCW4; protein.
DR Bgee; ENSG00000196437; Expressed in sperm and 158 other tissues.
DR ExpressionAtlas; Q5MCW4; baseline and differential.
DR Genevisible; Q5MCW4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 18.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..686
FT /note="Zinc finger protein 569"
FT /id="PRO_0000047659"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 186..208
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 438..460
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 466..488
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 494..516
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 522..544
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 550..572
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 578..600
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 606..628
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 634..656
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 662..684
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..159
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_055966"
FT VARIANT 29
FT /note="Q -> E (in a breast cancer sample; somatic
FT mutation)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035589"
FT VARIANT 87
FT /note="E -> G (in a breast cancer sample; somatic mutation;
FT dbSNP:rs1349967796)"
FT /evidence="ECO:0000269|PubMed:16959974"
FT /id="VAR_035590"
FT CONFLICT 598
FT /note="R -> G (in Ref. 2; AK056615)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 686 AA; 79583 MW; B95FC95665EA561B CRC64;
MTESQGTVTF KDVAIDFTQE EWKRLDPAQR KLYRNVMLEN YNNLITVGYP FTKPDVIFKL
EQEEEPWVME EEVLRRHWQG EIWGVDEHQK NQDRLLRQVE VKFQKTLTEE KGNECQKKFA
NVFPLNSDFF PSRHNLYEYD LFGKCLEHNF DCHNNVKCLM RKEHCEYNEP VKSYGNSSSH
FVITPFKCNH CGKGFNQTLD LIRHLRIHTG EKPYECSNCR KAFSHKEKLI KHYKIHSREQ
SYKCNECGKA FIKMSNLIRH QRIHTGEKPY ACKECEKSFS QKSNLIDHEK IHTGEKPYEC
NECGKAFSQK QSLIAHQKVH TGEKPYACNE CGKAFPRIAS LALHMRSHTG EKPYKCDKCG
KAFSQFSMLI IHVRIHTGEK PYECNECGKA FSQSSALTVH MRSHTGEKPY ECKECRKAFS
HKKNFITHQK IHTREKPYEC NECGKAFIQM SNLVRHQRIH TGEKPYICKE CGKAFSQKSN
LIAHEKIHSG EKPYECNECG KAFSQKQNFI THQKVHTGEK PYDCNECGKA FSQIASLTLH
LRSHTGEKPY ECDKCGKAFS QCSLLNLHMR SHTGEKPYVC NECGKAFSQR TSLIVHMRGH
TGEKPYECNK CGKAFSQSSS LTIHIRGHTG EKPFDCSKCG KAFSQISSLT LHMRKHTGEK
PYHCIECGKA FSQKSHLVRH QRIHTH
