ZN569_MOUSE
ID ZN569_MOUSE Reviewed; 679 AA.
AC Q80W31; E9QK35; O88237;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 2.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 569;
DE AltName: Full=Mszf21;
DE AltName: Full=Zinc finger protein 74;
DE Short=Zfp-74;
GN Name=Znf569; Synonyms=Zfp74;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J;
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Embryo;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 540-596.
RC STRAIN=C57BL/6J;
RX PubMed=9630514; DOI=10.1016/s0378-1119(98)00213-3;
RA Agata Y., Matsuda E., Shimizu A.;
RT "Rapid and efficient cloning of cDNAs encoding Krueppel-like zinc finger
RT proteins by degenerate PCR.";
RL Gene 213:55-64(1998).
CC -!- FUNCTION: May be involved in transcriptional regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AC149283; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC050048; AAH50048.1; -; mRNA.
DR EMBL; AB010334; BAA31390.1; -; mRNA.
DR CCDS; CCDS39874.1; -.
DR RefSeq; NP_848471.2; NM_178384.3.
DR RefSeq; XP_006540447.1; XM_006540384.3.
DR RefSeq; XP_006540448.1; XM_006540385.3.
DR RefSeq; XP_011249022.1; XM_011250720.2.
DR AlphaFoldDB; Q80W31; -.
DR SMR; Q80W31; -.
DR STRING; 10090.ENSMUSP00000103840; -.
DR iPTMnet; Q80W31; -.
DR PhosphoSitePlus; Q80W31; -.
DR MaxQB; Q80W31; -.
DR PaxDb; Q80W31; -.
DR PRIDE; Q80W31; -.
DR ProteomicsDB; 299588; -.
DR Antibodypedia; 44797; 93 antibodies from 15 providers.
DR DNASU; 72723; -.
DR Ensembl; ENSMUST00000032797; ENSMUSP00000032797; ENSMUSG00000059975.
DR Ensembl; ENSMUST00000108205; ENSMUSP00000103840; ENSMUSG00000059975.
DR GeneID; 72723; -.
DR KEGG; mmu:72723; -.
DR UCSC; uc009gcr.1; mouse.
DR CTD; 72723; -.
DR MGI; MGI:107784; Zfp74.
DR VEuPathDB; HostDB:ENSMUSG00000059975; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154650; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q80W31; -.
DR OMA; QSYECNE; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q80W31; -.
DR TreeFam; TF337898; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 72723; 1 hit in 59 CRISPR screens.
DR ChiTaRS; Zfp74; mouse.
DR PRO; PR:Q80W31; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80W31; protein.
DR Bgee; ENSMUSG00000059975; Expressed in manus and 192 other tissues.
DR ExpressionAtlas; Q80W31; baseline and differential.
DR Genevisible; Q80W31; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 18.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 18.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 18.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..679
FT /note="Zinc finger protein 569"
FT /id="PRO_0000047660"
FT DOMAIN 8..79
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 179..201
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..229
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 235..257
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 263..285
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 291..313
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 319..341
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 347..369
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 375..397
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 403..425
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 431..453
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 459..481
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 487..509
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 515..537
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 543..565
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 571..593
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 599..621
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 627..649
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 655..677
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CONFLICT 343
FT /note="G -> R (in Ref. 2; AAH50048)"
FT /evidence="ECO:0000305"
FT CONFLICT 564
FT /note="S -> G (in Ref. 2; AAH50048)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 679 AA; 77248 MW; B8892BF42BA81BFE CRC64;
MTESEGLVTF KDVAIDFTQE EWKQLDPTQR NLYRNVMLEN YNNLITVGPP LTKPEVIFKL
EQEEEPCVVE REVLWRPCPG EILGIDEHQK IQDGQVFEGI VVTSEASECP EEFASTFFPN
ADSIPSMHSL FECDGVGECL EPNFGDDDVQ YPLPEEQFEY DDAMQPFHTS SPHFVLTPFK
CNHCGKGFSQ TLDLIRHLRV HTGGKLYECH QCGKGFSHKE KLINHHKLHS REQCYECSEC
GKTFIKMSNL IRHQRIHTGE KPYVCQECGK SFGQKSNLID HEKIHTGEKP YKCNECGKSF
SQKQSLVAHQ KVHTGEKPYA CNECGKAFPR VASLALHMRG HTGEKPYKCD KCGKAFSQFS
MLIIHVRVHT GEKPYECGEC GKAFSQSSAL TVHIRSHTGE KPYECKECRK SFSHKKNFIT
HQKIHTREKP YGCNECGKAF IQMSNLVRHQ RIHTGEKPYL CKECGKAFSQ KSNLIAHEKI
HSGEKPYECN ECGKAFSQKQ NFITHQKVHT GEKPYDCNKC GKAFSQIASL TLHLRSHTGE
KPYECEKCGK AFSQCSLLNL HMRSHTGEKP YVCNECGKAF SQRTSLIVHM RGHTGEKPYE
CNKCGKAFSQ SSSLTIHIRG HTGEKPFDCS NCGKAFSQIS SLTLHMRKHT GEKPYVCIEC
GKAFSQKSHL VRHQRIHTH
