ZN571_HUMAN
ID ZN571_HUMAN Reviewed; 609 AA.
AC Q7Z3V5; Q2HIY0; Q3ZCU3; Q9NZX7;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-MAR-2007, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 571;
GN Name=ZNF571; ORFNames=HSPC059;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANTS ASP-252 AND HIS-573.
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-189.
RC TISSUE=Retina;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT HIS-189.
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF161544; AAF29031.2; -; mRNA.
DR EMBL; BX537401; CAD97643.1; -; mRNA.
DR EMBL; BC040591; AAH40591.1; -; mRNA.
DR EMBL; BC113870; AAI13871.1; -; mRNA.
DR CCDS; CCDS12505.1; -.
DR RefSeq; NP_001277243.1; NM_001290314.1.
DR RefSeq; NP_001308201.1; NM_001321272.1.
DR RefSeq; NP_057620.3; NM_016536.4.
DR AlphaFoldDB; Q7Z3V5; -.
DR SMR; Q7Z3V5; -.
DR BioGRID; 119428; 4.
DR IntAct; Q7Z3V5; 2.
DR iPTMnet; Q7Z3V5; -.
DR PhosphoSitePlus; Q7Z3V5; -.
DR BioMuta; ZNF571; -.
DR DMDM; 134047978; -.
DR EPD; Q7Z3V5; -.
DR jPOST; Q7Z3V5; -.
DR MassIVE; Q7Z3V5; -.
DR MaxQB; Q7Z3V5; -.
DR PaxDb; Q7Z3V5; -.
DR PeptideAtlas; Q7Z3V5; -.
DR PRIDE; Q7Z3V5; -.
DR ProteomicsDB; 69092; -.
DR Antibodypedia; 29923; 92 antibodies from 18 providers.
DR DNASU; 51276; -.
DR Ensembl; ENST00000328550.6; ENSP00000333660.2; ENSG00000180479.14.
DR Ensembl; ENST00000358744.3; ENSP00000351594.3; ENSG00000180479.14.
DR Ensembl; ENST00000451802.7; ENSP00000392638.1; ENSG00000180479.14.
DR Ensembl; ENST00000593133.5; ENSP00000467572.1; ENSG00000180479.14.
DR GeneID; 51276; -.
DR KEGG; hsa:51276; -.
DR MANE-Select; ENST00000451802.7; ENSP00000392638.1; NM_016536.5; NP_057620.3.
DR UCSC; uc002ogt.4; human.
DR CTD; 51276; -.
DR GeneCards; ZNF571; -.
DR HGNC; HGNC:25000; ZNF571.
DR HPA; ENSG00000180479; Tissue enhanced (thyroid).
DR neXtProt; NX_Q7Z3V5; -.
DR OpenTargets; ENSG00000180479; -.
DR PharmGKB; PA134892585; -.
DR VEuPathDB; HostDB:ENSG00000180479; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163517; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q7Z3V5; -.
DR OMA; LQWENMR; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q7Z3V5; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q7Z3V5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q7Z3V5; -.
DR BioGRID-ORCS; 51276; 12 hits in 1084 CRISPR screens.
DR ChiTaRS; ZNF571; human.
DR GeneWiki; ZNF571; -.
DR GenomeRNAi; 51276; -.
DR Pharos; Q7Z3V5; Tdark.
DR PRO; PR:Q7Z3V5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q7Z3V5; protein.
DR Bgee; ENSG00000180479; Expressed in secondary oocyte and 123 other tissues.
DR ExpressionAtlas; Q7Z3V5; baseline and differential.
DR Genevisible; Q7Z3V5; HS.
DR GO; GO:0005634; C:nucleus; IDA:LIFEdb.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 16.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 16.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..609
FT /note="Zinc finger protein 571"
FT /id="PRO_0000047662"
FT DOMAIN 6..84
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 139..161
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 164..189
FT /note="C2H2-type 2; atypical"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 195..217
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 223..245
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 251..273
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 279..301
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 307..329
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 335..357
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 363..385
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 391..413
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 419..441
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 447..469
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 474..496
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 502..524
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 530..552
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 558..580
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 586..608
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 170
FT /note="K -> M (in dbSNP:rs16973893)"
FT /id="VAR_052869"
FT VARIANT 189
FT /note="Q -> H (in dbSNP:rs8111790)"
FT /evidence="ECO:0000269|PubMed:15489334,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_023953"
FT VARIANT 252
FT /note="E -> D (in dbSNP:rs28512414)"
FT /evidence="ECO:0000269|PubMed:11042152"
FT /id="VAR_023954"
FT VARIANT 573
FT /note="L -> H (in dbSNP:rs4802029)"
FT /evidence="ECO:0000269|PubMed:11042152"
FT /id="VAR_023955"
FT VARIANT 593
FT /note="K -> E (in dbSNP:rs16973890)"
FT /id="VAR_031093"
FT CONFLICT 62
FT /note="I -> V (in Ref. 2; CAD97643)"
FT /evidence="ECO:0000305"
FT CONFLICT 102
FT /note="S -> N (in Ref. 3; AAH40591)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 609 AA; 70792 MW; 7DAA91B38A806EF1 CRC64;
MPHLLVTFRD VAIDFSQEEW ECLDPAQRDL YRDVMLENYS NLISLDLESS CVTKKLSPEK
EIYEMESLQW ENMGKRINHH LQYNGLGDNM ECKGNLEGQE ASQEGLYMCV KITCEEKATE
SHSTSSTFHR IIPTKEKLYK CKECRQGFSY LSCLIQHEEN HNIEKCSEVK KHRNTFSKKP
SYIQHQRIQT GEKPYECMEC GKAFGRTSDL IQHQKIHTNE KPYQCNACGK AFIRGSQLTE
HQRVHTGEKP YECKKCGKAF SYCSQYTLHQ RIHSGEKPYE CKDCGKAFIL GSQLTYHQRI
HSGEKPYECK ECGKAFILGS HLTYHQRVHT GEKPYICKEC GKAFLCASQL NEHQRIHTGE
KPYECKECGK TFFRGSQLTY HLRVHSGERP YKCKECGKAF ISNSNLIQHQ RIHTGEKPYK
CKECGKAFIC GKQLSEHQRI HTGEKPFECK ECGKAFIRVA YLTQHEKIHG EKHYECKECG
KTFVRATQLT YHQRIHTGEK PYKCKECDKA FIYGSQLSEH QRIHRGEKPY ECKQCGKAFI
RGSHLTEHLR THTGEKPYEC KECGRAFSRG SELTLHQRIH TGEKPYTCVQ CGKDFRCPSQ
LTQHTRLHN
