ZN573_HUMAN
ID ZN573_HUMAN Reviewed; 665 AA.
AC Q86YE8; B7WPE1; K7EJ45; Q6P1P1; Q7Z7Q3; Q8N2Q1; Q96BM3; Q96NH0;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 03-SEP-2014, sequence version 4.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 573;
GN Name=ZNF573;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 4).
RC TISSUE=Brain, and Embryo;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Duodenum, Eye, Lung, and Uterus;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=4;
CC Name=1;
CC IsoId=Q86YE8-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q86YE8-2; Sequence=VSP_022895;
CC Name=3;
CC IsoId=Q86YE8-3; Sequence=VSP_022894;
CC Name=4;
CC IsoId=Q86YE8-4; Sequence=VSP_022896, VSP_022897;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH42170.2; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK055483; BAB70929.1; -; mRNA.
DR EMBL; AK074539; BAC11047.1; -; mRNA.
DR EMBL; AC093227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC016582; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC015418; AAH15418.1; -; mRNA.
DR EMBL; BC042170; AAH42170.2; ALT_INIT; mRNA.
DR EMBL; BC051263; AAH51263.1; -; mRNA.
DR EMBL; BC064962; AAH64962.1; -; mRNA.
DR CCDS; CCDS12508.1; -. [Q86YE8-3]
DR CCDS; CCDS54260.1; -. [Q86YE8-2]
DR CCDS; CCDS59381.1; -. [Q86YE8-1]
DR RefSeq; NP_001166160.1; NM_001172689.1. [Q86YE8-2]
DR RefSeq; NP_001166161.1; NM_001172690.1. [Q86YE8-1]
DR RefSeq; NP_001166162.1; NM_001172691.1.
DR RefSeq; NP_001166163.1; NM_001172692.1. [Q86YE8-2]
DR RefSeq; NP_689573.3; NM_152360.3. [Q86YE8-3]
DR RefSeq; XP_016881769.1; XM_017026280.1.
DR RefSeq; XP_016881770.1; XM_017026281.1.
DR AlphaFoldDB; Q86YE8; -.
DR SMR; Q86YE8; -.
DR BioGRID; 125967; 6.
DR IntAct; Q86YE8; 1.
DR STRING; 9606.ENSP00000440464; -.
DR iPTMnet; Q86YE8; -.
DR PhosphoSitePlus; Q86YE8; -.
DR BioMuta; ZNF573; -.
DR DMDM; 143811478; -.
DR EPD; Q86YE8; -.
DR jPOST; Q86YE8; -.
DR MassIVE; Q86YE8; -.
DR MaxQB; Q86YE8; -.
DR PaxDb; Q86YE8; -.
DR PeptideAtlas; Q86YE8; -.
DR PRIDE; Q86YE8; -.
DR ProteomicsDB; 70406; -. [Q86YE8-1]
DR ProteomicsDB; 70407; -. [Q86YE8-2]
DR ProteomicsDB; 70408; -. [Q86YE8-3]
DR ProteomicsDB; 70409; -. [Q86YE8-4]
DR Antibodypedia; 29955; 25 antibodies from 9 providers.
DR DNASU; 126231; -.
DR Ensembl; ENST00000339503.7; ENSP00000340171.4; ENSG00000189144.15. [Q86YE8-3]
DR Ensembl; ENST00000392138.5; ENSP00000375983.1; ENSG00000189144.15. [Q86YE8-4]
DR Ensembl; ENST00000536220.7; ENSP00000440464.2; ENSG00000189144.15. [Q86YE8-1]
DR GeneID; 126231; -.
DR KEGG; hsa:126231; -.
DR MANE-Select; ENST00000536220.7; ENSP00000440464.2; NM_001172690.2; NP_001166161.1.
DR UCSC; uc002ohe.3; human. [Q86YE8-1]
DR CTD; 126231; -.
DR GeneCards; ZNF573; -.
DR HGNC; HGNC:26420; ZNF573.
DR HPA; ENSG00000189144; Low tissue specificity.
DR neXtProt; NX_Q86YE8; -.
DR OpenTargets; ENSG00000189144; -.
DR PharmGKB; PA134883623; -.
DR VEuPathDB; HostDB:ENSG00000189144; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163768; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q86YE8; -.
DR OMA; CEVISYV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q86YE8; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q86YE8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q86YE8; -.
DR BioGRID-ORCS; 126231; 11 hits in 1090 CRISPR screens.
DR ChiTaRS; ZNF573; human.
DR GenomeRNAi; 126231; -.
DR Pharos; Q86YE8; Tdark.
DR PRO; PR:Q86YE8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86YE8; protein.
DR Bgee; ENSG00000189144; Expressed in nipple and 198 other tissues.
DR ExpressionAtlas; Q86YE8; baseline and differential.
DR Genevisible; Q86YE8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 17.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 19.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..665
FT /note="Zinc finger protein 573"
FT /id="PRO_0000274877"
FT DOMAIN 28..100
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 134..156
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 162..184
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..576
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 582..604
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 610..632
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 638..660
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..97
FT /note="MFPVLEPHQVGLIRSYNSKTMTCFQELVTFRDVAIDFSRQEWEYLDPNQRDL
FT YRDVMLENYRNLVSLGGHSISKPVVVDLLERGKEPWMILREETQF -> MESCSVAQAG
FT VQWPDLSSLQPPPPRFKQFSCHSLQVAGI (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_022894"
FT VAR_SEQ 1..88
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022895"
FT VAR_SEQ 1..56
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022896"
FT VAR_SEQ 68..98
FT /note="Missing (in isoform 4)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_022897"
FT VARIANT 186
FT /note="G -> A (in dbSNP:rs3752365)"
FT /id="VAR_030356"
FT VARIANT 224
FT /note="G -> A (in dbSNP:rs3752365)"
FT /id="VAR_057426"
FT CONFLICT 129
FT /note="K -> E (in Ref. 1; BAB70929)"
FT /evidence="ECO:0000305"
FT CONFLICT 329
FT /note="P -> L (in Ref. 1; BAB70929)"
FT /evidence="ECO:0000305"
FT CONFLICT 523
FT /note="M -> V (in Ref. 3; AAH15418/AAH42170/AAH51263/
FT AAH64962)"
FT /evidence="ECO:0000305"
FT CONFLICT 591
FT /note="F -> L (in Ref. 1; BAC11047)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 665 AA; 78181 MW; F3BC0CDF3ADD2241 CRC64;
MFPVLEPHQV GLIRSYNSKT MTCFQELVTF RDVAIDFSRQ EWEYLDPNQR DLYRDVMLEN
YRNLVSLGGH SISKPVVVDL LERGKEPWMI LREETQFTDL DLQCEIISYI EVPTYETDIS
STQLQSIYKR EKLYECKKCQ KKFSSGYQLI LHHRFHVIER PYECKECGKN FRSGYQLTLH
QRFHTGEKPY ECTECGKNFR SGYQLTVHQR FHTGEKTYEC RQCGKAFIYA SHIVQHERIH
TGGKPYECQE CGRAFSQGGH LRIHQRVHTG EKPYKCKECG KTFSRRSNLV EHGQFHTDEK
PYICEKCGKA FRRGHQLTVH QRVHTGKKPY ECKECGKGYT TASYFLLHQR IHKGGKPYEC
KECKKTFTLY RNLTRHQNIH TGEKLFECKQ CGKTYTTGSK LFQHQKTHTG EKPYECKECG
KAFSLYGYLK QHQKIHTGMK HFECKECKKT FTLYRNLTRH QNIHTGKKLF ECQECGKAYS
TGSNLIQHRK THTGEKPYKC KECGKTFSLH GYLNQHQKIH TGMKPYECKV CRKTFTFYRN
LTLHQSIHTD EKPFECKECG KTFRRSSHLT AHQSIHADKK PYECKECGKA FKMYGYLTQH
QKIHTGGKPY ECKECGKAFS RASNLVQHER IHTGEKPYVC KQCGKTFRYG SALKAHQRIH
RSIKV
