ZN574_MOUSE
ID ZN574_MOUSE Reviewed; 900 AA.
AC Q8BY46; Q3TDE5; Q3UNU1; Q8BKB5;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 574;
GN Name=Znf574; Synonyms=Zfp574;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J, and NOD; TISSUE=Dendritic cell, Eye, Kidney, and Thymus;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-301, AND IDENTIFICATION BY
RP MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brain, Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAC35502.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK042074; BAC31155.1; -; mRNA.
DR EMBL; AK053744; BAC35502.1; ALT_FRAME; mRNA.
DR EMBL; AK143997; BAE25656.1; -; mRNA.
DR EMBL; AK170243; BAE41657.1; -; mRNA.
DR EMBL; BC059044; AAH59044.1; -; mRNA.
DR CCDS; CCDS20971.1; -.
DR RefSeq; NP_001161978.1; NM_001168506.1.
DR RefSeq; NP_780686.1; NM_175477.4.
DR RefSeq; XP_006539914.1; XM_006539851.3.
DR RefSeq; XP_006539915.1; XM_006539852.3.
DR RefSeq; XP_017177647.1; XM_017322158.1.
DR AlphaFoldDB; Q8BY46; -.
DR SMR; Q8BY46; -.
DR BioGRID; 231340; 1.
DR IntAct; Q8BY46; 1.
DR STRING; 10090.ENSMUSP00000057817; -.
DR iPTMnet; Q8BY46; -.
DR PhosphoSitePlus; Q8BY46; -.
DR EPD; Q8BY46; -.
DR MaxQB; Q8BY46; -.
DR PaxDb; Q8BY46; -.
DR PeptideAtlas; Q8BY46; -.
DR PRIDE; Q8BY46; -.
DR ProteomicsDB; 275296; -.
DR Antibodypedia; 30883; 64 antibodies from 21 providers.
DR DNASU; 232976; -.
DR Ensembl; ENSMUST00000053410; ENSMUSP00000057817; ENSMUSG00000045252.
DR Ensembl; ENSMUST00000179556; ENSMUSP00000136547; ENSMUSG00000045252.
DR GeneID; 232976; -.
DR KEGG; mmu:232976; -.
DR UCSC; uc009frj.2; mouse.
DR CTD; 232976; -.
DR MGI; MGI:2442951; Zfp574.
DR VEuPathDB; HostDB:ENSMUSG00000045252; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161799; -.
DR HOGENOM; CLU_002678_24_1_1; -.
DR InParanoid; Q8BY46; -.
DR OMA; PQRFECG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8BY46; -.
DR TreeFam; TF350791; -.
DR BioGRID-ORCS; 232976; 15 hits in 73 CRISPR screens.
DR ChiTaRS; Zfp574; mouse.
DR PRO; PR:Q8BY46; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8BY46; protein.
DR Bgee; ENSMUSG00000045252; Expressed in seminiferous tubule of testis and 242 other tissues.
DR Genevisible; Q8BY46; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 20.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..900
FT /note="Zinc finger protein 574"
FT /id="PRO_0000274863"
FT ZN_FING 16..38
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 76..98
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 126..148
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..235
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 312..334
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 339..361
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 367..389
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 395..416
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 469..492
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..576
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 582..604
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 610..633
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 639..662
FT /note="C2H2-type 15; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 670..692
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 742..764
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 770..792
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 798..820
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 826..848
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 244..306
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 246..260
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 716..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0007744|PubMed:21183079"
FT MOD_RES 721
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 728
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 836
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT CONFLICT 201
FT /note="T -> A (in Ref. 1; BAE41657)"
FT /evidence="ECO:0000305"
FT CONFLICT 504
FT /note="G -> S (in Ref. 1; BAE25656)"
FT /evidence="ECO:0000305"
FT CONFLICT 699
FT /note="E -> D (in Ref. 1; BAC35502)"
FT /evidence="ECO:0000305"
FT CONFLICT 701
FT /note="L -> V (in Ref. 1; BAC35502)"
FT /evidence="ECO:0000305"
FT CONFLICT 731
FT /note="A -> S (in Ref. 1; BAC35502)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 900 AA; 99461 MW; 6D3E87AE7CF5D14B CRC64;
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLVHQNSHVP QQHFELVGVA DPGVTVATEA
ASGTGLYQTL IQESQYQCLE CGQLLLSPSQ LLEHQELHLK MMAPQEAVPA KPPPKVPPLG
SSAIHYECVD CKALFASQEM WLSHRQTHLR ATPNKAPAPV VLGSPVVLGP PVGQARVAVE
HSYRKAEEGG EGAAVPSVAA TTEMVTEVEL LLYKCSECSQ LFQMPADFLE HQATHFPAPV
PEAAEPATQQ ETQVPSPTEA AVSQPEPLPA SDHSYELRNE LRNGEAIGRD RRGRKPRRNN
SGESGGAATQ ELFCSACDQL FLSPHQLQQH LRSHREGVFK CPLCSRVFPS PSSLDQHLGD
HSSESHFLCV DCGLAFGTEA LLLAHRRAHT PNPLHSCPCG KTFVNLTKFL YHRRTHGAGG
VPLPTTPVPP EEPAISFPEP APAETGELEA PELPVCEESS AEPAAPGSYR CLLCSREFGK
ALQLTRHQRF VHRLERRHKC SICGKMFKKK SHVRNHLRTH TGERPFPCPD CSKPFNSPAN
LARHRLTHTG ERPYRCGDCG KAFTQSSTLR QHRLVHAQHF PYRCQECGVR FHRPYRLLMH
RYHHTGEYPY KCRECPRSFL LRRLLEVHQL VIHAGRQPYR CSSCGAAFPS SLRLREHRCA
AAAAQAPRRF ECGTCGKKVG SAARLQAHEA AHAAAGPGEV LAKEPPAPRA SRATRTPVAP
SPTALSGTTS AAPAAPARRR GPECSECKKL FSTETSLQVH RRIHTGERPY PCPDCGKAFR
QSTHLKDHRR LHTGERPFAC EVCGKAFAIS MRLAEHRRIH TGERPYSCPD CGKSYRSFSN
LWKHRKTHQQ QHQAAVRQQL AEAEAAVGLA VMETAVEALP LVEAIEIYPL AEADGVQISG
