CC90B_MOUSE
ID CC90B_MOUSE Reviewed; 256 AA.
AC Q8C3X2; Q8JZY3; Q9D7C1;
DT 24-JUL-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 120.
DE RecName: Full=Coiled-coil domain-containing protein 90B, mitochondrial;
DE Flags: Precursor;
GN Name=Ccdc90b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
RC STRAIN=C57BL/6J; TISSUE=Heart, and Tongue;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Mammary gland;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Brown adipose tissue, Heart, Kidney, Liver, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- SUBUNIT: Interacts with MCU. {ECO:0000250|UniProtKB:Q9GZT6}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion membrane
CC {ECO:0000250|UniProtKB:Q9GZT6}; Single-pass membrane protein
CC {ECO:0000255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8C3X2-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8C3X2-2; Sequence=VSP_027004;
CC -!- SIMILARITY: Belongs to the CCDC90 family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK084673; BAC39246.1; -; mRNA.
DR EMBL; AK009370; BAB26248.1; -; mRNA.
DR EMBL; BC034878; AAH34878.1; -; mRNA.
DR EMBL; BC115973; AAI15974.1; -; mRNA.
DR CCDS; CCDS21449.1; -. [Q8C3X2-1]
DR CCDS; CCDS52309.1; -. [Q8C3X2-2]
DR RefSeq; NP_001156390.1; NM_001162918.1. [Q8C3X2-2]
DR RefSeq; NP_079791.2; NM_025515.3. [Q8C3X2-1]
DR AlphaFoldDB; Q8C3X2; -.
DR SMR; Q8C3X2; -.
DR BioGRID; 211416; 2.
DR IntAct; Q8C3X2; 1.
DR MINT; Q8C3X2; -.
DR STRING; 10090.ENSMUSP00000032842; -.
DR iPTMnet; Q8C3X2; -.
DR PhosphoSitePlus; Q8C3X2; -.
DR EPD; Q8C3X2; -.
DR jPOST; Q8C3X2; -.
DR MaxQB; Q8C3X2; -.
DR PaxDb; Q8C3X2; -.
DR PeptideAtlas; Q8C3X2; -.
DR PRIDE; Q8C3X2; -.
DR ProteomicsDB; 265302; -. [Q8C3X2-1]
DR ProteomicsDB; 265303; -. [Q8C3X2-2]
DR Antibodypedia; 2471; 130 antibodies from 21 providers.
DR DNASU; 66365; -.
DR Ensembl; ENSMUST00000032842; ENSMUSP00000032842; ENSMUSG00000030613. [Q8C3X2-1]
DR Ensembl; ENSMUST00000085017; ENSMUSP00000082090; ENSMUSG00000030613. [Q8C3X2-2]
DR GeneID; 66365; -.
DR KEGG; mmu:66365; -.
DR UCSC; uc009ihv.2; mouse. [Q8C3X2-1]
DR UCSC; uc009ihw.2; mouse. [Q8C3X2-2]
DR CTD; 60492; -.
DR MGI; MGI:1913615; Ccdc90b.
DR VEuPathDB; HostDB:ENSMUSG00000030613; -.
DR eggNOG; KOG3156; Eukaryota.
DR GeneTree; ENSGT00940000155453; -.
DR HOGENOM; CLU_063283_1_0_1; -.
DR InParanoid; Q8C3X2; -.
DR OMA; QAVAMMK; -.
DR OrthoDB; 1252164at2759; -.
DR PhylomeDB; Q8C3X2; -.
DR TreeFam; TF331442; -.
DR BioGRID-ORCS; 66365; 3 hits in 71 CRISPR screens.
DR ChiTaRS; Ccdc90b; mouse.
DR PRO; PR:Q8C3X2; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q8C3X2; protein.
DR Bgee; ENSMUSG00000030613; Expressed in atrioventricular valve and 254 other tissues.
DR Genevisible; Q8C3X2; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0031966; C:mitochondrial membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005739; C:mitochondrion; HDA:MGI.
DR InterPro; IPR024461; CCDC90-like.
DR PANTHER; PTHR14360; PTHR14360; 1.
DR Pfam; PF07798; DUF1640; 1.
PE 1: Evidence at protein level;
KW Alternative splicing; Coiled coil; Membrane; Mitochondrion;
KW Reference proteome; Transit peptide; Transmembrane; Transmembrane helix.
FT TRANSIT 1..42
FT /note="Mitochondrion"
FT /evidence="ECO:0000255"
FT CHAIN 43..256
FT /note="Coiled-coil domain-containing protein 90B,
FT mitochondrial"
FT /id="PRO_0000295696"
FT TRANSMEM 231..253
FT /note="Helical"
FT /evidence="ECO:0000255"
FT COILED 129..167
FT /evidence="ECO:0000255"
FT VAR_SEQ 109..142
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_027004"
FT CONFLICT 15
FT /note="G -> C (in Ref. 1; BAB26248)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 256 AA; 29597 MW; 0F5BB3CBDA61994B CRC64;
MRSRWIWRFL RPDGGGIRWT STPHGRLSPA LRRGFLTTTT KSDYDRRPVD ITPLEQRKLT
FDTHALVQDL ETHGFDKTQA QTIVSVLSTL SNVSLDTIYK EMVTKAQQEI TVQQLMAHLD
SIRKDMVILE KSEFANLRAE NEKMKIELDQ VKQQLTNETS RIRADNKLDI NLERSRVTDM
FTDQEKQLIE ATNEFAKKDT QTKSIISETS NKIDTEIASL KTLMESSKLE TIRYLAASVF
TCLAIALGFY RFWKEN
