ZN574_RAT
ID ZN574_RAT Reviewed; 898 AA.
AC Q504L7;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 07-JUN-2005, sequence version 1.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Zinc finger protein 574;
GN Name=Znf574; Synonyms=Zfp574;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Ovary;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC094953; AAH94953.1; -; mRNA.
DR RefSeq; NP_001019429.1; NM_001024258.1.
DR RefSeq; XP_008757152.1; XM_008758930.1.
DR RefSeq; XP_008757153.1; XM_008758931.2.
DR AlphaFoldDB; Q504L7; -.
DR SMR; Q504L7; -.
DR STRING; 10116.ENSRNOP00000061367; -.
DR PaxDb; Q504L7; -.
DR PRIDE; Q504L7; -.
DR Ensembl; ENSRNOT00000079847; ENSRNOP00000070796; ENSRNOG00000055761.
DR Ensembl; ENSRNOT00000096464; ENSRNOP00000083524; ENSRNOG00000055761.
DR Ensembl; ENSRNOT00000100383; ENSRNOP00000097450; ENSRNOG00000055761.
DR Ensembl; ENSRNOT00000109238; ENSRNOP00000097321; ENSRNOG00000055761.
DR Ensembl; ENSRNOT00000110459; ENSRNOP00000089598; ENSRNOG00000055761.
DR Ensembl; ENSRNOT00000116503; ENSRNOP00000082869; ENSRNOG00000055761.
DR GeneID; 308434; -.
DR KEGG; rno:308434; -.
DR UCSC; RGD:1311420; rat.
DR CTD; 232976; -.
DR RGD; 1311420; Zfp574.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161799; -.
DR HOGENOM; CLU_002678_24_1_1; -.
DR InParanoid; Q504L7; -.
DR OMA; PQRFECG; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q504L7; -.
DR TreeFam; TF350791; -.
DR PRO; PR:Q504L7; -.
DR Proteomes; UP000002494; Chromosome 1.
DR Bgee; ENSRNOG00000055761; Expressed in testis and 20 other tissues.
DR Genevisible; Q504L7; RN.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 20.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Methylation; Nucleus; Phosphoprotein;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..898
FT /note="Zinc finger protein 574"
FT /id="PRO_0000274865"
FT ZN_FING 16..38
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 76..98
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 126..148
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..235
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 310..332
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 337..359
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..414
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 467..490
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 496..518
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 524..546
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 552..574
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 580..602
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 608..631
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 637..660
FT /note="C2H2-type 15; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 668..690
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 740..762
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 768..790
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 796..818
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 824..846
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 243..305
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..460
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 691..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 273..299
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 421..435
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 164
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 301
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 719
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 726
FT /note="Phosphothreonine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
FT MOD_RES 834
FT /note="Asymmetric dimethylarginine"
FT /evidence="ECO:0000250|UniProtKB:Q6ZN55"
SQ SEQUENCE 898 AA; 99355 MW; 2FA8BEC612F99693 CRC64;
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLVHQNSHVP QQHFELVGVA DPGVTVATEA
TSGTGLYQTL IQESQYQCLE CGQLLLSPSQ LLEHQELHLK MMAPQEAVPA EPPPKVPPLS
SSTIHYECVD CKALFASQEM WLSHRQTHLR ATPNKAPAPV VLGSPVVLGP PVGQARVAVE
HSYRKAEEGG EGAAVPSVAA ATEMVTEVEL LLYKCSECSQ LFQMPADFLE HQATHFPAPV
PEAEEPATQQ ETLVPSPTEA AVSQPDPLPA SDHSYELRNE LRNGEAMGRD RRGRKPRRSS
SGESGATQEL FCSACDQIFL SPHQLQQHLR SHREGVFKCP LCSRVFPSPS SLDQHLGDHS
SESHFLCVDC GLAFGTEALL LAHRRAHTPN PLHSCPCGKT FVNLTKFLYH RRTHGAGGVP
LPTTPVPPEE PAISFPEPAP AETGELEAPE LPVSEESSAE PAAPGTYRCL LCSREFSKAL
QLTRHQRFVH RLERRHKCSI CGKMFKKKSH VRNHLRTHTG ERPFPCPDCS KPFNSPANLA
RHRLTHTGER PYRCGDCGKA FTQSSTLRQH RLVHAQHFPY RCQECGVRFH RPYRLLMHRY
HHTGEYPYKC RECPRSFLLR RLLEVHQLVV HAGRQPHRCP SCGAAFPSSL RLREHRCAAA
AAQAPRRFEC GTCGKKVGSA ARLQAHEAAH AAAGPGEVLA KEPPAPRAAR ATRTPVAPSP
TALGGTTSAA PAAPARRRGL ECSECKKLFS TETSLQVHRR IHTGERPYPC PDCGKAFRQS
THLKDHRRLH TGERPFACEV CGKAFAISMR LAEHRRIHTG ERPYSCPDCG KSYRSFSNLW
KHRKTHQQQH QAAVRQQLAE AEAAVGLAVM ETAVEALPLV EAIEIYPLAE ADGVQISG
