ZN574_XENTR
ID ZN574_XENTR Reviewed; 857 AA.
AC Q6GL52;
DT 06-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT 19-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Zinc finger protein 574;
GN Name=znf574;
OS Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX NCBI_TaxID=8364;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Embryo;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC074658; AAH74658.1; -; mRNA.
DR RefSeq; NP_001004843.1; NM_001004843.1.
DR RefSeq; XP_012821811.1; XM_012966357.2.
DR AlphaFoldDB; Q6GL52; -.
DR SMR; Q6GL52; -.
DR STRING; 8364.ENSXETP00000057402; -.
DR PaxDb; Q6GL52; -.
DR DNASU; 448126; -.
DR Ensembl; ENSXETT00000057402; ENSXETP00000057402; ENSXETG00000027536.
DR GeneID; 448126; -.
DR KEGG; xtr:448126; -.
DR CTD; 64763; -.
DR Xenbase; XB-GENE-1004140; znf574.
DR eggNOG; KOG1721; Eukaryota.
DR HOGENOM; CLU_002678_24_1_1; -.
DR InParanoid; Q6GL52; -.
DR OMA; EDCAMEL; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6GL52; -.
DR TreeFam; TF350791; -.
DR Proteomes; UP000008143; Chromosome 7.
DR Proteomes; UP000790000; Unplaced.
DR Bgee; ENSXETG00000027536; Expressed in blastula and 13 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 20.
DR SUPFAM; SSF57667; SSF57667; 10.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 19.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..857
FT /note="Zinc finger protein 574"
FT /id="PRO_0000274866"
FT ZN_FING 15..37
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 58..80
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 99..121
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 206..228
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 297..319
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..401
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..451
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 457..479
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 485..507
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 513..535
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 541..563
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 569..591
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 597..619
FT /note="C2H2-type 15; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 628..651
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 681..703
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 709..731
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 737..759
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 765..787
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 648..678
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 857 AA; 97090 MW; B9F27F36B7DC3618 CRC64;
MTDSEETVLY VEHRYVCSEC GEEYPSLEEA LEHQQSHAAA LQEPQYQIVG VNSLENQYQC
LECGLLLRTP EDLLAHQELH PTQNEIQKPK RPTRSEIHYE CPECKALFNS QDVWMAHRYT
HMQVQDVSHS KIVLQTDDHV IEDGLQLMCA PAVPSEVHLV TGDPHFHVST PSSASVSHTQ
VLVDLEHSYK KNEGAGEDCA MELLLYKCSE CTQLFQTPGE FLEHQGTHFS GQERISDTNS
HLDQTPQLSL NGQEKEPIIN QGNTCTDYQA ENKELLVQPE GEQAEQDSWT VDREPVFSCG
DCSETFQTTK DLEEHQISHQ NGPFSCPLCS KVFPTYPEVG EHLKSHRSES RYLCVDCGLA
FVSEAVLLNH RRSHLANPLF TCECGLTFLN MTRFLYHRRV HSSKQPDTGA VEEKKTVNSI
APSPAGNFHC DPCGKDFPLL SQFLRHQRFV HALERRHKCP TCGKHFKKGS HLRTHMLTHT
GERPYSCTVC SKSFNSQANL LRHRLTHTGE KPYKCQLCGK AFSQSSTLQQ HQYVHGQAYL
YKCNECGINF HRPYRLLLHQ YHHTGEYPYK CQDCGLSFLL KRLLEVHQLG HRGEEPHRCR
ECGTNFPSVQ RLQDHRCSKA GDGGGEKLEC PICGKKVTSD AHLNTHVAAQ HSGNKRSNVS
SGKGTPVLPR NKLKGGGGKN LECSDCHKTF STETSLQVHR RIHTGERPYP CPDCGKAFRQ
STHLKDHRRL HTGEKPFKCD VCGKAFTIAV RLSEHKRIHT GERPHSCPDC GRAYRSFSNL
WKHRKLHREQ QVQLQEPESQ PADLSSTVAI LETVETIPII ETVEIFPEGS TISVQDIQFE
TLQVENIHLG NIQIGTL
