ZN575_HUMAN
ID ZN575_HUMAN Reviewed; 245 AA.
AC Q86XF7; B4DX54;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 149.
DE RecName: Full=Zinc finger protein 575;
GN Name=ZNF575;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Pancreas;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q86XF7; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-14069183, EBI-3866279;
CC Q86XF7; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-14069183, EBI-3867333;
CC Q86XF7; P54257: HAP1; NbExp=5; IntAct=EBI-14069183, EBI-712814;
CC Q86XF7; P61978-2: HNRNPK; NbExp=5; IntAct=EBI-14069183, EBI-7060731;
CC Q86XF7; O75525: KHDRBS3; NbExp=3; IntAct=EBI-14069183, EBI-722504;
CC Q86XF7; Q6A162: KRT40; NbExp=3; IntAct=EBI-14069183, EBI-10171697;
CC Q86XF7; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-14069183, EBI-10172290;
CC Q86XF7; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-14069183, EBI-10171774;
CC Q86XF7; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-14069183, EBI-11988175;
CC Q86XF7; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-14069183, EBI-14065470;
CC Q86XF7; Q6L8H4: KRTAP5-1; NbExp=3; IntAct=EBI-14069183, EBI-12074540;
CC Q86XF7; Q9BYQ4: KRTAP9-2; NbExp=5; IntAct=EBI-14069183, EBI-1044640;
CC Q86XF7; Q9BYQ3: KRTAP9-3; NbExp=3; IntAct=EBI-14069183, EBI-1043191;
CC Q86XF7; Q9UPT6: MAPK8IP3; NbExp=3; IntAct=EBI-14069183, EBI-717887;
CC Q86XF7; Q99750: MDFI; NbExp=3; IntAct=EBI-14069183, EBI-724076;
CC Q86XF7; P13349: MYF5; NbExp=3; IntAct=EBI-14069183, EBI-17491620;
CC Q86XF7; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-14069183, EBI-79165;
CC Q86XF7; Q8WV41: SNX33; NbExp=3; IntAct=EBI-14069183, EBI-2481535;
CC Q86XF7; Q7Z698: SPRED2; NbExp=3; IntAct=EBI-14069183, EBI-7082156;
CC Q86XF7; Q63HR2: TNS2; NbExp=3; IntAct=EBI-14069183, EBI-949753;
CC Q86XF7; Q05BL1: TP53BP2; NbExp=3; IntAct=EBI-14069183, EBI-11952721;
CC Q86XF7; Q8WV44: TRIM41; NbExp=3; IntAct=EBI-14069183, EBI-725997;
CC Q86XF7; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-14069183, EBI-11035148;
CC Q86XF7; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-14069183, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK301820; BAG63266.1; -; mRNA.
DR EMBL; CH471126; EAW57198.1; -; Genomic_DNA.
DR EMBL; BC043611; AAH43611.1; -; mRNA.
DR CCDS; CCDS12623.1; -.
DR RefSeq; NP_777605.1; NM_174945.2.
DR RefSeq; XP_005258840.1; XM_005258783.3.
DR RefSeq; XP_011525095.1; XM_011526793.2.
DR AlphaFoldDB; Q86XF7; -.
DR SMR; Q86XF7; -.
DR BioGRID; 129835; 26.
DR IntAct; Q86XF7; 24.
DR STRING; 9606.ENSP00000315870; -.
DR iPTMnet; Q86XF7; -.
DR PhosphoSitePlus; Q86XF7; -.
DR BioMuta; ZNF575; -.
DR DMDM; 74762460; -.
DR MassIVE; Q86XF7; -.
DR PaxDb; Q86XF7; -.
DR PeptideAtlas; Q86XF7; -.
DR PRIDE; Q86XF7; -.
DR ProteomicsDB; 70274; -.
DR Antibodypedia; 17608; 132 antibodies from 23 providers.
DR DNASU; 284346; -.
DR Ensembl; ENST00000314228.10; ENSP00000315870.4; ENSG00000176472.11.
DR Ensembl; ENST00000598080.6; ENSP00000471083.2; ENSG00000176472.11.
DR Ensembl; ENST00000601282.1; ENSP00000472578.1; ENSG00000176472.11.
DR GeneID; 284346; -.
DR KEGG; hsa:284346; -.
DR MANE-Select; ENST00000314228.10; ENSP00000315870.4; NM_174945.3; NP_777605.1.
DR UCSC; uc002ows.4; human.
DR CTD; 284346; -.
DR DisGeNET; 284346; -.
DR GeneCards; ZNF575; -.
DR HGNC; HGNC:27606; ZNF575.
DR HPA; ENSG00000176472; Low tissue specificity.
DR neXtProt; NX_Q86XF7; -.
DR OpenTargets; ENSG00000176472; -.
DR PharmGKB; PA134958979; -.
DR VEuPathDB; HostDB:ENSG00000176472; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162551; -.
DR HOGENOM; CLU_069747_0_0_1; -.
DR InParanoid; Q86XF7; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q86XF7; -.
DR TreeFam; TF338022; -.
DR PathwayCommons; Q86XF7; -.
DR SignaLink; Q86XF7; -.
DR BioGRID-ORCS; 284346; 15 hits in 1089 CRISPR screens.
DR ChiTaRS; ZNF575; human.
DR GenomeRNAi; 284346; -.
DR Pharos; Q86XF7; Tdark.
DR PRO; PR:Q86XF7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q86XF7; protein.
DR Bgee; ENSG00000176472; Expressed in mucosa of transverse colon and 100 other tissues.
DR ExpressionAtlas; Q86XF7; baseline and differential.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 5.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 4.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..245
FT /note="Zinc finger protein 575"
FT /id="PRO_0000047664"
FT ZN_FING 63..85
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 91..113
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 119..141
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 147..169
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 177..199
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 213..240
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..67
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 245 AA; 26763 MW; 14AA1DD275F8ABB6 CRC64;
MLERGAESAA GATDPSPTGK EPVTKEAPHQ GPPQKPSQSA PGPTASAGSP PRPRRRPPPQ
RPHRCPDCDK AFSYPSKLAT HRLAHGGARP HPCPDCPKAF SYPSKLAAHR LTHSGARPHP
CPHCPKSFGH RSKLAAHLWT HAPTRPYPCP DCPKSFCYPS KLAAHRHTHH ATDARPYPCP
HCPKAFSFPS KLAAHRLCHD PPTAPGSQAT AWHRCSSCGQ AFGQRRLLLL HQRSHHQVEH
KGERD
