ZN575_MOUSE
ID ZN575_MOUSE Reviewed; 239 AA.
AC Q3TXZ1;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Zinc finger protein 575;
GN Name=Znf575; Synonyms=Zfp575;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Visual cortex;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK159025; BAE34773.1; -; mRNA.
DR CCDS; CCDS20956.1; -.
DR RefSeq; NP_001028377.1; NM_001033205.3.
DR RefSeq; XP_006539509.1; XM_006539446.3.
DR AlphaFoldDB; Q3TXZ1; -.
DR SMR; Q3TXZ1; -.
DR STRING; 10090.ENSMUSP00000092294; -.
DR iPTMnet; Q3TXZ1; -.
DR PhosphoSitePlus; Q3TXZ1; -.
DR PaxDb; Q3TXZ1; -.
DR PRIDE; Q3TXZ1; -.
DR ProteomicsDB; 302090; -.
DR Antibodypedia; 17608; 132 antibodies from 23 providers.
DR Ensembl; ENSMUST00000094705; ENSMUSP00000092294; ENSMUSG00000066721.
DR GeneID; 101544; -.
DR KEGG; mmu:101544; -.
DR UCSC; uc009fqa.1; mouse.
DR CTD; 101544; -.
DR MGI; MGI:2141921; Zfp575.
DR VEuPathDB; HostDB:ENSMUSG00000066721; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162551; -.
DR HOGENOM; CLU_069747_0_0_1; -.
DR InParanoid; Q3TXZ1; -.
DR OMA; WIHTPER; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3TXZ1; -.
DR TreeFam; TF338022; -.
DR BioGRID-ORCS; 101544; 3 hits in 72 CRISPR screens.
DR PRO; PR:Q3TXZ1; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3TXZ1; protein.
DR Bgee; ENSMUSG00000066721; Expressed in embryonic brain and 46 other tissues.
DR ExpressionAtlas; Q3TXZ1; baseline and differential.
DR Genevisible; Q3TXZ1; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 6.
DR SUPFAM; SSF57667; SSF57667; 3.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 6.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 6.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..239
FT /note="Zinc finger protein 575"
FT /id="PRO_0000047666"
FT ZN_FING 57..79
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 85..107
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 113..135
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 141..163
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 171..193
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 207..230
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..62
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 239 AA; 26282 MW; 7606F7DDFC24616A CRC64;
MLGGSVKSEV RASEPSPTCQ DPETKAPHQD LPRPNQPAAS GSVPSRPRRR PPPQRPHRCP
DCPKAFSYPS KLATHRLAHG GTRPHPCPDC PKAFSYPSKL AAHRLTHSGA RPHSCPHCPK
AFGHRSKLAA HLWTHAPARP YPCPDCPKSF CYPSKLAAHR HTHHATDARP YPCPHCPKAF
SFPSKLAAHR LCHDPPTAPS SQATGSHRCS SCNQAFGQRR LLLVHQRSHH QSEGQGERE
