ZN576_HUMAN
ID ZN576_HUMAN Reviewed; 170 AA.
AC Q9H609; Q9BU03;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 152.
DE RecName: Full=Zinc finger protein 576;
GN Name=ZNF576;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Small intestine;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LEU-81.
RC TISSUE=Lung;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9H609; Q9Y6B7: AP4B1; NbExp=7; IntAct=EBI-3921014, EBI-1047606;
CC Q9H609; O15145: ARPC3; NbExp=3; IntAct=EBI-3921014, EBI-351829;
CC Q9H609; P19012: KRT15; NbExp=3; IntAct=EBI-3921014, EBI-739566;
CC Q9H609; P43358: MAGEA4; NbExp=5; IntAct=EBI-3921014, EBI-743122;
CC Q9H609; Q9NRD5: PICK1; NbExp=3; IntAct=EBI-3921014, EBI-79165;
CC Q9H609; Q86WC6: PPP1R27; NbExp=3; IntAct=EBI-3921014, EBI-5235602;
CC Q9H609; Q9Y371: SH3GLB1; NbExp=6; IntAct=EBI-3921014, EBI-2623095;
CC Q9H609; Q08117: TLE5; NbExp=3; IntAct=EBI-3921014, EBI-717810;
CC Q9H609; P61758: VBP1; NbExp=3; IntAct=EBI-3921014, EBI-357430;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: Overlaps in opposite strand with ZNF428. {ECO:0000305}.
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DR EMBL; AK026353; BAB15458.1; -; mRNA.
DR EMBL; AC006276; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC002981; AAH02981.1; -; mRNA.
DR CCDS; CCDS12625.1; -.
DR RefSeq; NP_001138819.1; NM_001145347.1.
DR RefSeq; NP_077303.1; NM_024327.2.
DR AlphaFoldDB; Q9H609; -.
DR SMR; Q9H609; -.
DR BioGRID; 122594; 26.
DR IntAct; Q9H609; 24.
DR STRING; 9606.ENSP00000337852; -.
DR iPTMnet; Q9H609; -.
DR PhosphoSitePlus; Q9H609; -.
DR BioMuta; ZNF576; -.
DR DMDM; 74761466; -.
DR jPOST; Q9H609; -.
DR MassIVE; Q9H609; -.
DR MaxQB; Q9H609; -.
DR PaxDb; Q9H609; -.
DR PeptideAtlas; Q9H609; -.
DR PRIDE; Q9H609; -.
DR ProteomicsDB; 80947; -.
DR Antibodypedia; 31088; 27 antibodies from 8 providers.
DR DNASU; 79177; -.
DR Ensembl; ENST00000336564.5; ENSP00000337852.4; ENSG00000124444.16.
DR Ensembl; ENST00000391965.6; ENSP00000375827.2; ENSG00000124444.16.
DR Ensembl; ENST00000525771.1; ENSP00000436182.1; ENSG00000124444.16.
DR Ensembl; ENST00000528387.5; ENSP00000435934.1; ENSG00000124444.16.
DR Ensembl; ENST00000529930.1; ENSP00000435463.1; ENSG00000124444.16.
DR Ensembl; ENST00000533118.5; ENSP00000435899.1; ENSG00000124444.16.
DR GeneID; 79177; -.
DR KEGG; hsa:79177; -.
DR MANE-Select; ENST00000336564.5; ENSP00000337852.4; NM_001145347.2; NP_001138819.1.
DR UCSC; uc002owy.3; human.
DR CTD; 79177; -.
DR GeneCards; ZNF576; -.
DR HGNC; HGNC:28357; ZNF576.
DR HPA; ENSG00000124444; Low tissue specificity.
DR neXtProt; NX_Q9H609; -.
DR OpenTargets; ENSG00000124444; -.
DR PharmGKB; PA134950110; -.
DR VEuPathDB; HostDB:ENSG00000124444; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00730000111407; -.
DR HOGENOM; CLU_133887_0_0_1; -.
DR InParanoid; Q9H609; -.
DR OMA; GLHEHYI; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9H609; -.
DR TreeFam; TF350821; -.
DR PathwayCommons; Q9H609; -.
DR SignaLink; Q9H609; -.
DR BioGRID-ORCS; 79177; 9 hits in 1091 CRISPR screens.
DR GenomeRNAi; 79177; -.
DR Pharos; Q9H609; Tdark.
DR PRO; PR:Q9H609; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9H609; protein.
DR Bgee; ENSG00000124444; Expressed in prefrontal cortex and 179 other tissues.
DR ExpressionAtlas; Q9H609; baseline and differential.
DR Genevisible; Q9H609; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043565; F:sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 1.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 3.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..170
FT /note="Zinc finger protein 576"
FT /id="PRO_0000047667"
FT ZN_FING 34..57
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 71..93
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 112..134
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 143..165
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..29
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..15
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 81
FT /note="P -> L (in dbSNP:rs17849705)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_023956"
SQ SEQUENCE 170 AA; 18890 MW; 4EFAA311147613C1 CRC64;
MEDPNPEENM KQQDSPKERS PQSPGGNICH LGAPKCTRCL ITFADSKFQE RHMKREHPAD
FVAQKLQGVL FICFTCARSF PSSKALITHQ RSHGPAAKPT LPVATTTAQP TFPCPDCGKT
FGQAVSLRRH RQMHEVRAPP GTFACTECGQ DFAQEAGLHQ HYIRHARGEL
