ZN577_HUMAN
ID ZN577_HUMAN Reviewed; 485 AA.
AC Q9BSK1; A8K0B4; A8K6Z7; C9JFB9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 20-APR-2010, sequence version 3.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 577;
GN Name=ZNF577;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
RC TISSUE=Cerebellum, and Prostate;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANTS VAL-84;
RP CYS-123 AND GLU-246.
RC TISSUE=Skin;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q9BSK1-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9BSK1-2; Sequence=VSP_040810;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- CAUTION: It is uncertain whether Met-1 or Met-8 is the initiator.
CC {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAH04992.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=BAF82168.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=EAW72049.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AK289479; BAF82168.1; ALT_INIT; mRNA.
DR EMBL; AK291812; BAF84501.1; -; mRNA.
DR EMBL; AC006272; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC011460; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC074141; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72049.1; ALT_SEQ; Genomic_DNA.
DR EMBL; BC004992; AAH04992.1; ALT_INIT; mRNA.
DR CCDS; CCDS12842.2; -. [Q9BSK1-1]
DR CCDS; CCDS46160.1; -. [Q9BSK1-2]
DR RefSeq; NP_001129062.1; NM_001135590.1. [Q9BSK1-2]
DR RefSeq; NP_116068.2; NM_032679.2. [Q9BSK1-1]
DR RefSeq; XP_006723495.1; XM_006723432.3.
DR RefSeq; XP_006723496.1; XM_006723433.2.
DR RefSeq; XP_011525710.1; XM_011527408.2.
DR RefSeq; XP_016882876.1; XM_017027387.1.
DR AlphaFoldDB; Q9BSK1; -.
DR SMR; Q9BSK1; -.
DR BioGRID; 124246; 5.
DR IntAct; Q9BSK1; 1.
DR STRING; 9606.ENSP00000301399; -.
DR iPTMnet; Q9BSK1; -.
DR PhosphoSitePlus; Q9BSK1; -.
DR BioMuta; ZNF577; -.
DR DMDM; 294862491; -.
DR MassIVE; Q9BSK1; -.
DR PaxDb; Q9BSK1; -.
DR PeptideAtlas; Q9BSK1; -.
DR PRIDE; Q9BSK1; -.
DR ProteomicsDB; 78909; -. [Q9BSK1-1]
DR ProteomicsDB; 78910; -. [Q9BSK1-2]
DR Antibodypedia; 19054; 67 antibodies from 21 providers.
DR DNASU; 84765; -.
DR Ensembl; ENST00000301399.12; ENSP00000301399.5; ENSG00000161551.15. [Q9BSK1-1]
DR Ensembl; ENST00000451628.9; ENSP00000389652.2; ENSG00000161551.15. [Q9BSK1-2]
DR Ensembl; ENST00000638348.2; ENSP00000491936.2; ENSG00000161551.15. [Q9BSK1-1]
DR Ensembl; ENST00000639636.2; ENSP00000491349.1; ENSG00000161551.15. [Q9BSK1-2]
DR GeneID; 84765; -.
DR KEGG; hsa:84765; -.
DR MANE-Select; ENST00000638348.2; ENSP00000491936.2; NM_001370449.1; NP_001357378.1.
DR UCSC; uc002pxx.6; human. [Q9BSK1-1]
DR CTD; 84765; -.
DR DisGeNET; 84765; -.
DR GeneCards; ZNF577; -.
DR HGNC; HGNC:28673; ZNF577.
DR HPA; ENSG00000161551; Low tissue specificity.
DR neXtProt; NX_Q9BSK1; -.
DR OpenTargets; ENSG00000161551; -.
DR PharmGKB; PA134942499; -.
DR VEuPathDB; HostDB:ENSG00000161551; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163379; -.
DR HOGENOM; CLU_002678_0_2_1; -.
DR InParanoid; Q9BSK1; -.
DR OMA; EPPWIVE; -.
DR PhylomeDB; Q9BSK1; -.
DR TreeFam; TF337922; -.
DR PathwayCommons; Q9BSK1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9BSK1; -.
DR BioGRID-ORCS; 84765; 20 hits in 1094 CRISPR screens.
DR ChiTaRS; ZNF577; human.
DR GenomeRNAi; 84765; -.
DR Pharos; Q9BSK1; Tdark.
DR PRO; PR:Q9BSK1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9BSK1; protein.
DR Bgee; ENSG00000161551; Expressed in left testis and 130 other tissues.
DR ExpressionAtlas; Q9BSK1; baseline and differential.
DR Genevisible; Q9BSK1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 7.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..485
FT /note="Zinc finger protein 577"
FT /id="PRO_0000234590"
FT DOMAIN 23..94
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 158..180
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 186..208
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 95..153
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_040810"
FT VARIANT 84
FT /note="A -> V (in dbSNP:rs17856123)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055139"
FT VARIANT 123
FT /note="R -> C (in dbSNP:rs17849895)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055140"
FT VARIANT 234
FT /note="R -> K (in dbSNP:rs9807847)"
FT /id="VAR_055141"
FT VARIANT 246
FT /note="K -> E (in dbSNP:rs2288868)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_055142"
FT VARIANT 346
FT /note="R -> C (in dbSNP:rs9807842)"
FT /id="VAR_055143"
FT VARIANT 357
FT /note="R -> S (in dbSNP:rs9807853)"
FT /id="VAR_033577"
FT VARIANT 373
FT /note="E -> K (in dbSNP:rs10407547)"
FT /id="VAR_055144"
FT VARIANT 375
FT /note="T -> I (in dbSNP:rs10407911)"
FT /id="VAR_055145"
FT CONFLICT 50
FT /note="E -> G (in Ref. 1; BAF84501)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 485 AA; 54939 MW; F2DB53CD82CBF8D5 CRC64;
MKNATIVMSV RREQGSSSGE GSLSFEDVAV GFTREEWQFL DQSQKVLYKE VMLENYINLV
SIGYRGTKPD SLFKLEQGEP PGIAEGAAHS QICPGFVIQS RRYAGKDSDA FGGYGRSCLH
IKRDKTLTGV KYHRCVKPSS PKSQLNDLQK ICAGGKPHEC SVCGRAFSRK AQLIQHQRTE
RGEKPHGCGE CGKTFMRKIQ LTEHQRTHTG EKPHECSECG KAFSRKSQLM VHQRTHTGEK
PYRCSKCGKA FSRKCRLNRH QRSHTGEKLY GCSVCGKAFS QKAYLTAHQR LHTGDKPYKC
SDCGRTFYFK SDLTRHQRIH TGEKPYECSE CEKAFRSKSK LIQHQRTHTG ERPYSCRECG
KAFAHMSVLI KHEKTHIRET AINSLTVEKP SSRSHTSLYM SELIQEQKTV NTVPIEMPSS
GTPPLLNKSE RLVGRNVVIV EQPFPRNQAF VVNQEFEQRI SLTNEVNVAP SVINYILYLT
DIVSE
