ZN578_HUMAN
ID ZN578_HUMAN Reviewed; 590 AA.
AC Q96N58; B4DR51; I3L1Y6;
DT 27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT 03-APR-2013, sequence version 2.
DT 03-AUG-2022, entry version 156.
DE RecName: Full=Zinc finger protein 578;
GN Name=ZNF578;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT LYS-238.
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96N58; O95273: CCNDBP1; NbExp=3; IntAct=EBI-11955189, EBI-748961;
CC Q96N58; Q8NHQ1: CEP70; NbExp=3; IntAct=EBI-11955189, EBI-739624;
CC Q96N58; Q96Q77: CIB3; NbExp=3; IntAct=EBI-11955189, EBI-10292696;
CC Q96N58; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-11955189, EBI-5916454;
CC Q96N58; P60370: KRTAP10-5; NbExp=3; IntAct=EBI-11955189, EBI-10172150;
CC Q96N58; P60409: KRTAP10-7; NbExp=3; IntAct=EBI-11955189, EBI-10172290;
CC Q96N58; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-11955189, EBI-10171774;
CC Q96N58; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-11955189, EBI-11953334;
CC Q96N58; Q9BYP8: KRTAP17-1; NbExp=3; IntAct=EBI-11955189, EBI-11988175;
CC Q96N58; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-11955189, EBI-14065470;
CC Q96N58; Q99750: MDFI; NbExp=3; IntAct=EBI-11955189, EBI-724076;
CC Q96N58; Q8TF50: ZNF526; NbExp=3; IntAct=EBI-11955189, EBI-11035148;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAB71051.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AK055946; BAB71051.1; ALT_INIT; mRNA.
DR EMBL; AK299106; BAG61163.1; -; mRNA.
DR EMBL; AC010332; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010506; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72083.1; -; Genomic_DNA.
DR CCDS; CCDS54310.1; -.
DR RefSeq; NP_001093164.1; NM_001099694.1.
DR RefSeq; XP_016881791.1; XM_017026302.1.
DR AlphaFoldDB; Q96N58; -.
DR SMR; Q96N58; -.
DR BioGRID; 127070; 15.
DR IntAct; Q96N58; 12.
DR STRING; 9606.ENSP00000459216; -.
DR iPTMnet; Q96N58; -.
DR PhosphoSitePlus; Q96N58; -.
DR BioMuta; ZNF578; -.
DR DMDM; 476007824; -.
DR EPD; Q96N58; -.
DR jPOST; Q96N58; -.
DR MassIVE; Q96N58; -.
DR MaxQB; Q96N58; -.
DR PaxDb; Q96N58; -.
DR PeptideAtlas; Q96N58; -.
DR PRIDE; Q96N58; -.
DR ProteomicsDB; 46783; -.
DR ProteomicsDB; 77467; -.
DR Antibodypedia; 56948; 71 antibodies from 12 providers.
DR DNASU; 147660; -.
DR Ensembl; ENST00000421239.7; ENSP00000459216.1; ENSG00000258405.11.
DR GeneID; 147660; -.
DR KEGG; hsa:147660; -.
DR MANE-Select; ENST00000421239.7; ENSP00000459216.1; NM_001099694.2; NP_001093164.1.
DR UCSC; uc002pzp.5; human.
DR CTD; 147660; -.
DR DisGeNET; 147660; -.
DR GeneCards; ZNF578; -.
DR HGNC; HGNC:26449; ZNF578.
DR HPA; ENSG00000258405; Tissue enhanced (testis).
DR neXtProt; NX_Q96N58; -.
DR OpenTargets; ENSG00000258405; -.
DR PharmGKB; PA134936072; -.
DR VEuPathDB; HostDB:ENSG00000258405; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000154397; -.
DR HOGENOM; CLU_002678_17_0_1; -.
DR InParanoid; Q96N58; -.
DR OMA; MCHSYLA; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96N58; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q96N58; -.
DR SignaLink; Q96N58; -.
DR BioGRID-ORCS; 147660; 14 hits in 999 CRISPR screens.
DR ChiTaRS; ZNF578; human.
DR GenomeRNAi; 147660; -.
DR Pharos; Q96N58; Tdark.
DR PRO; PR:Q96N58; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96N58; protein.
DR Bgee; ENSG00000258405; Expressed in cortical plate and 100 other tissues.
DR ExpressionAtlas; Q96N58; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 10.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..590
FT /note="Zinc finger protein 578"
FT /id="PRO_0000047668"
FT DOMAIN 24..98
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 231..253
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..365
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 371..393
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 399..421
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 427..449
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 455..477
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 483..505
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 511..533
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 539..561
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 238
FT /note="E -> K (in dbSNP:rs161931)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_069167"
SQ SEQUENCE 590 AA; 68531 MW; B2A987979C0574A9 CRC64;
MLHEEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKF LNPAQRALYR EVMLENYRNL
EAVDISSKRM MKEVLSTGQG NTEVIHTGML QRHESYHTGD FCFQEIEKDI HDFEFQSQKD
ERNGHEASMP KIKELMGSTD RHDQRHAGNK PIKDQLGLSF HLHLPELHIF QPEEKIANQV
EKSVNDASSI STSQRISCRP ETHTPNNYGN NFFHSSLLTQ KQEVHMREKS FQCNETGEAF
NCSSFVRKHQ IIHLGEKQYK FDICGKVFNE KRYLARHRRC HTSEKPYKCN ECGKSFSYKS
SLTCHRRCHT GEKPYKCNEC GKSFSYKSSL TCHHRCHTGE KPYKCNECGK SFSYKSSLRC
HRRLHTGIKP YKCNECGKMF GQNSTLVIHK AIHTGEKPYK CNECGKAFNQ QSHLSRHHRL
HTGEKPYKCN DCGKAFIHQS SLARHHRLHT GEKSYKCEEC DRVFSQKSNL ERHKIIHTGE
KPYKCNECHK TFSHRSSLPC HRRLHSGEKP YKCNECGKTF NVQSHLSRHH RLHTGEKPYK
CKVCDKAFMC HSYLANHTRI HSGEKPYKCN ECGKAHNHLI DSSIKPCMSS
