ZN579_MOUSE
ID ZN579_MOUSE Reviewed; 562 AA.
AC Q80VM4;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2003, sequence version 1.
DT 03-AUG-2022, entry version 144.
DE RecName: Full=Zinc finger protein 579;
GN Name=Znf579; Synonyms=Zfp579;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [2]
RP PROTEIN SEQUENCE OF 422-427, AND IDENTIFICATION BY MASS SPECTROMETRY.
RC STRAIN=OF1; TISSUE=Hippocampus;
RA Lubec G., Sunyer B., Chen W.-Q.;
RL Submitted (JAN-2009) to UniProtKB.
RN [3]
RP METHYLATION [LARGE SCALE ANALYSIS] AT ARG-94, AND IDENTIFICATION BY MASS
RP SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Embryo;
RX PubMed=24129315; DOI=10.1074/mcp.o113.027870;
RA Guo A., Gu H., Zhou J., Mulhern D., Wang Y., Lee K.A., Yang V., Aguiar M.,
RA Kornhauser J., Jia X., Ren J., Beausoleil S.A., Silva J.C., Vemulapalli V.,
RA Bedford M.T., Comb M.J.;
RT "Immunoaffinity enrichment and mass spectrometry analysis of protein
RT methylation.";
RL Mol. Cell. Proteomics 13:372-387(2014).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; BC048385; AAH48385.1; -; mRNA.
DR CCDS; CCDS39744.1; -.
DR RefSeq; NP_081017.1; NM_026741.2.
DR RefSeq; XP_006540398.1; XM_006540335.3.
DR AlphaFoldDB; Q80VM4; -.
DR iPTMnet; Q80VM4; -.
DR PhosphoSitePlus; Q80VM4; -.
DR MaxQB; Q80VM4; -.
DR PaxDb; Q80VM4; -.
DR PRIDE; Q80VM4; -.
DR ProteomicsDB; 302091; -.
DR Antibodypedia; 33125; 50 antibodies from 13 providers.
DR DNASU; 68490; -.
DR Ensembl; ENSMUST00000108572; ENSMUSP00000104212; ENSMUSG00000051550.
DR Ensembl; ENSMUST00000162731; ENSMUSP00000123963; ENSMUSG00000051550.
DR GeneID; 68490; -.
DR KEGG; mmu:68490; -.
DR UCSC; uc009ezc.1; mouse.
DR CTD; 68490; -.
DR MGI; MGI:1915740; Zfp579.
DR VEuPathDB; HostDB:ENSMUSG00000051550; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00930000151080; -.
DR HOGENOM; CLU_487114_0_0_1; -.
DR InParanoid; Q80VM4; -.
DR OMA; SWGPQDQ; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q80VM4; -.
DR TreeFam; TF331849; -.
DR BioGRID-ORCS; 68490; 3 hits in 73 CRISPR screens.
DR ChiTaRS; Zfp579; mouse.
DR PRO; PR:Q80VM4; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q80VM4; protein.
DR Bgee; ENSMUSG00000051550; Expressed in ear vesicle and 203 other tissues.
DR ExpressionAtlas; Q80VM4; baseline and differential.
DR Genevisible; Q80VM4; MM.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; ISO:MGI.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; ISO:MGI.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; ISO:MGI.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 7.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 1: Evidence at protein level;
KW Direct protein sequencing; DNA-binding; Metal-binding; Methylation;
KW Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription;
KW Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..562
FT /note="Zinc finger protein 579"
FT /id="PRO_0000047670"
FT ZN_FING 46..68
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 74..96
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 102..125
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 267..289
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 295..317
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 410..432
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 439..461
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..45
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 120..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 166..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 321..377
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 505..530
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 19..33
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 507..525
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 94
FT /note="Omega-N-methylarginine"
FT /evidence="ECO:0007744|PubMed:24129315"
FT MOD_RES 191
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NAF0"
FT MOD_RES 486
FT /note="Phosphoserine"
FT /evidence="ECO:0000250|UniProtKB:Q8NAF0"
SQ SEQUENCE 562 AA; 60792 MW; 788F3DB1627A3419 CRC64;
MDPQPPPPAQ GSPPHRDRGR GRGRGRGRGR GRGRGRGGAG APRAPLPCPT CGRLFRFPYY
LSRHRLSHSG LRPHACPLCP KAFRRPAHLS RHLRGHGPQP PLRCAACPRT FPEPAQLRRH
LAQEHAGSEV DLSTQRAVKE EPEASWGPQD EGVEQPATVV VAGAEEEATT QWPAGDSAPA
AVPTSTDPRE SEAKEAEAGA AELRAELALA AGRQEEKQVL LQADWTLLCL RCREAFATKG
ELKAHPCLRP EGEQEGEGGP PPRPKRHQCS ICLKAFARPW SLSRHRLVHS TDRPFVCPDC
GLAFRLASYL RQHRRVHGPL SLLAPLPGAG KKDDKASGGR NSGKGPEGGE GAECGGASEG
GEGGHNGGDA TPARPPAGEP RFWCPECGKG FRRRAHLRQH GVTHSGARPF QCVRCQREFK
RLADLARHAQ VHAGGPAPHP CPRCPRRFSR AYSLLRHQRC HRAELERAEL ERAAALQELQ
TQASQSPQPP QPLKQEAEGL PLPIAHIKEE PPSPGTPPQS PPAPPVFLSA SCFDSQDHSA
FEMEDEEMDS KAHLCGLGGL AS
