ZN581_HUMAN
ID ZN581_HUMAN Reviewed; 197 AA.
AC Q9P0T4; B2RDM6;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 581;
GN Name=ZNF581; ORFNames=HSPC189;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Umbilical cord blood;
RX PubMed=11042152; DOI=10.1101/gr.140200;
RA Zhang Q.-H., Ye M., Wu X.-Y., Ren S.-X., Zhao M., Zhao C.-J., Fu G.,
RA Shen Y., Fan H.-Y., Lu G., Zhong M., Xu X.-R., Han Z.-G., Zhang J.-W.,
RA Tao J., Huang Q.-H., Zhou J., Hu G.-X., Gu J., Chen S.-J., Chen Z.;
RT "Cloning and functional analysis of cDNAs with open reading frames for 300
RT previously undefined genes expressed in CD34+ hematopoietic stem/progenitor
RT cells.";
RL Genome Res. 10:1546-1560(2000).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Skeletal muscle;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=B-cell, Kidney, Muscle, and Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q9P0T4; Q96CW1: AP2M1; NbExp=3; IntAct=EBI-745520, EBI-297683;
CC Q9P0T4; Q9NRW3: APOBEC3C; NbExp=3; IntAct=EBI-745520, EBI-1044593;
CC Q9P0T4; Q8WXK3-2: ASB13; NbExp=3; IntAct=EBI-745520, EBI-12015080;
CC Q9P0T4; Q7Z3C6-3: ATG9A; NbExp=3; IntAct=EBI-745520, EBI-12006308;
CC Q9P0T4; Q8N9N5: BANP; NbExp=3; IntAct=EBI-745520, EBI-744695;
CC Q9P0T4; Q8N9N5-2: BANP; NbExp=3; IntAct=EBI-745520, EBI-11524452;
CC Q9P0T4; A0A087WZT3: BOLA2B; NbExp=3; IntAct=EBI-745520, EBI-12006120;
CC Q9P0T4; Q13895: BYSL; NbExp=3; IntAct=EBI-745520, EBI-358049;
CC Q9P0T4; Q13137: CALCOCO2; NbExp=3; IntAct=EBI-745520, EBI-739580;
CC Q9P0T4; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-745520, EBI-3866279;
CC Q9P0T4; Q8NA61: CBY2; NbExp=3; IntAct=EBI-745520, EBI-741724;
CC Q9P0T4; Q8NA61-2: CBY2; NbExp=3; IntAct=EBI-745520, EBI-11524851;
CC Q9P0T4; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-745520, EBI-10171416;
CC Q9P0T4; O95273: CCNDBP1; NbExp=3; IntAct=EBI-745520, EBI-748961;
CC Q9P0T4; Q8WUH1: CHURC1; NbExp=3; IntAct=EBI-745520, EBI-11156883;
CC Q9P0T4; Q9BYD5: CNFN; NbExp=3; IntAct=EBI-745520, EBI-12819063;
CC Q9P0T4; A8MQ03: CYSRT1; NbExp=6; IntAct=EBI-745520, EBI-3867333;
CC Q9P0T4; G5E9A7: DMWD; NbExp=3; IntAct=EBI-745520, EBI-10976677;
CC Q9P0T4; Q8NF50-2: DOCK8; NbExp=3; IntAct=EBI-745520, EBI-10174653;
CC Q9P0T4; Q01658: DR1; NbExp=3; IntAct=EBI-745520, EBI-750300;
CC Q9P0T4; Q92997: DVL3; NbExp=3; IntAct=EBI-745520, EBI-739789;
CC Q9P0T4; O95967: EFEMP2; NbExp=3; IntAct=EBI-745520, EBI-743414;
CC Q9P0T4; Q9H0I2: ENKD1; NbExp=3; IntAct=EBI-745520, EBI-744099;
CC Q9P0T4; Q16134: ETFDH; NbExp=3; IntAct=EBI-745520, EBI-2870454;
CC Q9P0T4; Q86YD7: FAM90A1; NbExp=3; IntAct=EBI-745520, EBI-6658203;
CC Q9P0T4; Q9NW38: FANCL; NbExp=3; IntAct=EBI-745520, EBI-2339898;
CC Q9P0T4; P22607: FGFR3; NbExp=3; IntAct=EBI-745520, EBI-348399;
CC Q9P0T4; Q5TD97: FHL5; NbExp=3; IntAct=EBI-745520, EBI-750641;
CC Q9P0T4; A1L4K1: FSD2; NbExp=6; IntAct=EBI-745520, EBI-5661036;
CC Q9P0T4; P14136: GFAP; NbExp=3; IntAct=EBI-745520, EBI-744302;
CC Q9P0T4; Q08379: GOLGA2; NbExp=3; IntAct=EBI-745520, EBI-618309;
CC Q9P0T4; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-745520, EBI-5916454;
CC Q9P0T4; Q9HD26: GOPC; NbExp=3; IntAct=EBI-745520, EBI-349832;
CC Q9P0T4; Q9Y4H4: GPSM3; NbExp=3; IntAct=EBI-745520, EBI-347538;
CC Q9P0T4; P06396: GSN; NbExp=3; IntAct=EBI-745520, EBI-351506;
CC Q9P0T4; Q9Y5Q9: GTF3C3; NbExp=3; IntAct=EBI-745520, EBI-1054873;
CC Q9P0T4; Q6NT76: HMBOX1; NbExp=6; IntAct=EBI-745520, EBI-2549423;
CC Q9P0T4; P52597: HNRNPF; NbExp=3; IntAct=EBI-745520, EBI-352986;
CC Q9P0T4; O75031: HSF2BP; NbExp=6; IntAct=EBI-745520, EBI-7116203;
CC Q9P0T4; Q13422: IKZF1; NbExp=3; IntAct=EBI-745520, EBI-745305;
CC Q9P0T4; Q14005-2: IL16; NbExp=3; IntAct=EBI-745520, EBI-17178971;
CC Q9P0T4; Q8WXH2: JPH3; NbExp=3; IntAct=EBI-745520, EBI-1055254;
CC Q9P0T4; Q5VWX1: KHDRBS2; NbExp=3; IntAct=EBI-745520, EBI-742808;
CC Q9P0T4; Q7Z3Y8: KRT27; NbExp=3; IntAct=EBI-745520, EBI-3044087;
CC Q9P0T4; O76011: KRT34; NbExp=3; IntAct=EBI-745520, EBI-1047093;
CC Q9P0T4; Q6A162: KRT40; NbExp=6; IntAct=EBI-745520, EBI-10171697;
CC Q9P0T4; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-745520, EBI-11959885;
CC Q9P0T4; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-745520, EBI-10172290;
CC Q9P0T4; P60410: KRTAP10-8; NbExp=3; IntAct=EBI-745520, EBI-10171774;
CC Q9P0T4; P60411: KRTAP10-9; NbExp=3; IntAct=EBI-745520, EBI-10172052;
CC Q9P0T4; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-745520, EBI-10176379;
CC Q9P0T4; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-745520, EBI-14065470;
CC Q9P0T4; Q9BQ66: KRTAP4-12; NbExp=4; IntAct=EBI-745520, EBI-739863;
CC Q9P0T4; Q9BYR5: KRTAP4-2; NbExp=3; IntAct=EBI-745520, EBI-10172511;
CC Q9P0T4; P26371: KRTAP5-9; NbExp=3; IntAct=EBI-745520, EBI-3958099;
CC Q9P0T4; Q3LI66: KRTAP6-2; NbExp=3; IntAct=EBI-745520, EBI-11962084;
CC Q9P0T4; Q8TBB1: LNX1; NbExp=6; IntAct=EBI-745520, EBI-739832;
CC Q9P0T4; Q9BRK4: LZTS2; NbExp=4; IntAct=EBI-745520, EBI-741037;
CC Q9P0T4; Q99750: MDFI; NbExp=8; IntAct=EBI-745520, EBI-724076;
CC Q9P0T4; Q5JR59: MTUS2; NbExp=4; IntAct=EBI-745520, EBI-742948;
CC Q9P0T4; Q8IV28: NID2; NbExp=3; IntAct=EBI-745520, EBI-10261509;
CC Q9P0T4; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-745520, EBI-945833;
CC Q9P0T4; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-745520, EBI-22310682;
CC Q9P0T4; Q9BRQ3: NUDT22; NbExp=3; IntAct=EBI-745520, EBI-10297093;
CC Q9P0T4; Q5VU43: PDE4DIP; NbExp=3; IntAct=EBI-745520, EBI-1105124;
CC Q9P0T4; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-745520, EBI-9640281;
CC Q9P0T4; Q16512: PKN1; NbExp=3; IntAct=EBI-745520, EBI-602382;
CC Q9P0T4; Q9UPG8: PLAGL2; NbExp=3; IntAct=EBI-745520, EBI-2876622;
CC Q9P0T4; Q9H8W4: PLEKHF2; NbExp=3; IntAct=EBI-745520, EBI-742388;
CC Q9P0T4; Q8ND90: PNMA1; NbExp=8; IntAct=EBI-745520, EBI-302345;
CC Q9P0T4; Q16633: POU2AF1; NbExp=3; IntAct=EBI-745520, EBI-943588;
CC Q9P0T4; O43741: PRKAB2; NbExp=3; IntAct=EBI-745520, EBI-1053424;
CC Q9P0T4; Q93062: RBPMS; NbExp=4; IntAct=EBI-745520, EBI-740322;
CC Q9P0T4; Q93062-3: RBPMS; NbExp=8; IntAct=EBI-745520, EBI-740343;
CC Q9P0T4; Q9UFD9: RIMBP3; NbExp=3; IntAct=EBI-745520, EBI-10182375;
CC Q9P0T4; Q96LW2: RSKR; NbExp=3; IntAct=EBI-745520, EBI-1054572;
CC Q9P0T4; Q9H190: SDCBP2; NbExp=3; IntAct=EBI-745520, EBI-742426;
CC Q9P0T4; Q14140: SERTAD2; NbExp=3; IntAct=EBI-745520, EBI-2822051;
CC Q9P0T4; Q92922: SMARCC1; NbExp=3; IntAct=EBI-745520, EBI-355653;
CC Q9P0T4; P35711: SOX5; NbExp=3; IntAct=EBI-745520, EBI-3505701;
CC Q9P0T4; Q99932-2: SPAG8; NbExp=3; IntAct=EBI-745520, EBI-11959123;
CC Q9P0T4; Q9NZD8: SPG21; NbExp=3; IntAct=EBI-745520, EBI-742688;
CC Q9P0T4; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-745520, EBI-5235340;
CC Q9P0T4; Q13148: TARDBP; NbExp=6; IntAct=EBI-745520, EBI-372899;
CC Q9P0T4; Q8WW24: TEKT4; NbExp=3; IntAct=EBI-745520, EBI-750487;
CC Q9P0T4; Q13077: TRAF1; NbExp=3; IntAct=EBI-745520, EBI-359224;
CC Q9P0T4; Q9BUZ4: TRAF4; NbExp=6; IntAct=EBI-745520, EBI-3650647;
CC Q9P0T4; P36406: TRIM23; NbExp=8; IntAct=EBI-745520, EBI-740098;
CC Q9P0T4; P14373: TRIM27; NbExp=6; IntAct=EBI-745520, EBI-719493;
CC Q9P0T4; Q15654: TRIP6; NbExp=3; IntAct=EBI-745520, EBI-742327;
CC Q9P0T4; P31930: UQCRC1; NbExp=3; IntAct=EBI-745520, EBI-1052596;
CC Q9P0T4; P61758: VBP1; NbExp=3; IntAct=EBI-745520, EBI-357430;
CC Q9P0T4; Q9NZC7-5: WWOX; NbExp=3; IntAct=EBI-745520, EBI-12040603;
CC Q9P0T4; Q7L2R6-2: ZNF765; NbExp=3; IntAct=EBI-745520, EBI-12834294;
CC Q9P0T4; Q3KQV3: ZNF792; NbExp=3; IntAct=EBI-745520, EBI-10240849;
CC Q9P0T4; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-745520, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
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DR EMBL; AF151023; AAF36109.2; -; mRNA.
DR EMBL; AK315603; BAG37973.1; -; mRNA.
DR EMBL; CH471135; EAW72400.1; -; Genomic_DNA.
DR EMBL; BC010097; AAH10097.1; -; mRNA.
DR EMBL; BC001219; AAH01219.1; -; mRNA.
DR EMBL; BC071620; AAH71620.1; -; mRNA.
DR EMBL; BC071845; AAH71845.1; -; mRNA.
DR CCDS; CCDS12932.1; -.
DR RefSeq; NP_057619.1; NM_016535.3.
DR RefSeq; XP_006723303.1; XM_006723240.3.
DR RefSeq; XP_016882356.1; XM_017026867.1.
DR AlphaFoldDB; Q9P0T4; -.
DR SMR; Q9P0T4; -.
DR BioGRID; 119601; 110.
DR IntAct; Q9P0T4; 115.
DR MINT; Q9P0T4; -.
DR STRING; 9606.ENSP00000466047; -.
DR iPTMnet; Q9P0T4; -.
DR MetOSite; Q9P0T4; -.
DR PhosphoSitePlus; Q9P0T4; -.
DR BioMuta; ZNF581; -.
DR DMDM; 55976774; -.
DR EPD; Q9P0T4; -.
DR jPOST; Q9P0T4; -.
DR MassIVE; Q9P0T4; -.
DR MaxQB; Q9P0T4; -.
DR PaxDb; Q9P0T4; -.
DR PeptideAtlas; Q9P0T4; -.
DR PRIDE; Q9P0T4; -.
DR ProteomicsDB; 83595; -.
DR Antibodypedia; 33134; 62 antibodies from 19 providers.
DR DNASU; 51545; -.
DR Ensembl; ENST00000270451.6; ENSP00000270451.4; ENSG00000171425.10.
DR Ensembl; ENST00000587252.5; ENSP00000466047.1; ENSG00000171425.10.
DR Ensembl; ENST00000588537.1; ENSP00000466564.1; ENSG00000171425.10.
DR GeneID; 51545; -.
DR KEGG; hsa:51545; -.
DR MANE-Select; ENST00000270451.6; ENSP00000270451.4; NM_016535.4; NP_057619.1.
DR UCSC; uc002qln.4; human.
DR CTD; 51545; -.
DR GeneCards; ZNF581; -.
DR HGNC; HGNC:25017; ZNF581.
DR HPA; ENSG00000171425; Low tissue specificity.
DR neXtProt; NX_Q9P0T4; -.
DR OpenTargets; ENSG00000171425; -.
DR PharmGKB; PA134899657; -.
DR VEuPathDB; HostDB:ENSG00000171425; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163608; -.
DR HOGENOM; CLU_002678_42_5_1; -.
DR InParanoid; Q9P0T4; -.
DR OMA; KHARWKH; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9P0T4; -.
DR PathwayCommons; Q9P0T4; -.
DR SignaLink; Q9P0T4; -.
DR BioGRID-ORCS; 51545; 13 hits in 1097 CRISPR screens.
DR ChiTaRS; ZNF581; human.
DR GenomeRNAi; 51545; -.
DR Pharos; Q9P0T4; Tdark.
DR PRO; PR:Q9P0T4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9P0T4; protein.
DR Bgee; ENSG00000171425; Expressed in upper arm skin and 154 other tissues.
DR ExpressionAtlas; Q9P0T4; baseline and differential.
DR Genevisible; Q9P0T4; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 3.
DR SMART; SM00355; ZnF_C2H2; 4.
DR SUPFAM; SSF57667; SSF57667; 2.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..197
FT /note="Zinc finger protein 581"
FT /id="PRO_0000047673"
FT ZN_FING 87..109
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 115..137
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 145..167
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 173..196
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 31..48
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 197 AA; 22010 MW; B62F1FAFD4829EE5 CRC64;
MLVLPSPCPQ PLAFSSVETM EGPPRRTCRS PEPGPSSSIG SPQASSPPRP NHYLLIDTQG
VPYTVLVDEE SQREPGASGA PGQKKCYSCP VCSRVFEYMS YLQRHSITHS EVKPFECDIC
GKAFKRASHL ARHHSIHLAG GGRPHGCPLC PRRFRDAGEL AQHSRVHSGE RPFQCPHCPR
RFMEQNTLQK HTRWKHP
