ZN583_HUMAN
ID ZN583_HUMAN Reviewed; 569 AA.
AC Q96ND8; O14850; Q2NKK3;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 159.
DE RecName: Full=Zinc finger protein 583;
DE AltName: Full=Zinc finger protein L3-5;
GN Name=ZNF583;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 309-361.
RC TISSUE=Liver;
RA Wu G., Yu L., Sun X., Wu M., Fan Y., Jiang C., Zheng Q., Zhang Q., Zhao S.;
RT "Isolation and cloning of novel C2-H2 type zinc finger protein gene in
RT human liver tissue.";
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK055592; BAB70964.1; -; mRNA.
DR EMBL; BC111772; AAI11773.1; -; mRNA.
DR EMBL; AF024698; AAB81088.1; -; mRNA.
DR CCDS; CCDS12943.1; -.
DR RefSeq; NP_001153332.1; NM_001159860.1.
DR RefSeq; NP_001153333.1; NM_001159861.1.
DR RefSeq; NP_689691.2; NM_152478.2.
DR RefSeq; XP_011524819.1; XM_011526517.2.
DR RefSeq; XP_016881839.1; XM_017026350.1.
DR AlphaFoldDB; Q96ND8; -.
DR SMR; Q96ND8; -.
DR IntAct; Q96ND8; 2.
DR MINT; Q96ND8; -.
DR STRING; 9606.ENSP00000388502; -.
DR GlyGen; Q96ND8; 1 site, 1 O-linked glycan (1 site).
DR iPTMnet; Q96ND8; -.
DR PhosphoSitePlus; Q96ND8; -.
DR BioMuta; ZNF583; -.
DR DMDM; 116242861; -.
DR jPOST; Q96ND8; -.
DR MassIVE; Q96ND8; -.
DR MaxQB; Q96ND8; -.
DR PaxDb; Q96ND8; -.
DR PeptideAtlas; Q96ND8; -.
DR PRIDE; Q96ND8; -.
DR ProteomicsDB; 77503; -.
DR Antibodypedia; 33209; 123 antibodies from 18 providers.
DR DNASU; 147949; -.
DR Ensembl; ENST00000291598.11; ENSP00000291598.7; ENSG00000198440.9.
DR Ensembl; ENST00000333201.13; ENSP00000388502.2; ENSG00000198440.9.
DR GeneID; 147949; -.
DR KEGG; hsa:147949; -.
DR MANE-Select; ENST00000333201.13; ENSP00000388502.2; NM_152478.3; NP_689691.2.
DR UCSC; uc002qnc.3; human.
DR CTD; 147949; -.
DR DisGeNET; 147949; -.
DR GeneCards; ZNF583; -.
DR HGNC; HGNC:26427; ZNF583.
DR HPA; ENSG00000198440; Low tissue specificity.
DR neXtProt; NX_Q96ND8; -.
DR OpenTargets; ENSG00000198440; -.
DR PharmGKB; PA134982111; -.
DR VEuPathDB; HostDB:ENSG00000198440; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161925; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q96ND8; -.
DR OMA; RVHKHEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96ND8; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q96ND8; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96ND8; -.
DR BioGRID-ORCS; 147949; 10 hits in 1091 CRISPR screens.
DR ChiTaRS; ZNF583; human.
DR GenomeRNAi; 147949; -.
DR Pharos; Q96ND8; Tdark.
DR PRO; PR:Q96ND8; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96ND8; protein.
DR Bgee; ENSG00000198440; Expressed in cortical plate and 106 other tissues.
DR ExpressionAtlas; Q96ND8; baseline and differential.
DR Genevisible; Q96ND8; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..569
FT /note="Zinc finger protein 583"
FT /id="PRO_0000047674"
FT DOMAIN 6..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 212..234
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 549..569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 324
FT /note="F -> I (in dbSNP:rs12976917)"
FT /id="VAR_027978"
FT CONFLICT 351
FT /note="P -> R (in Ref. 3; AAB81088)"
FT /evidence="ECO:0000305"
FT CONFLICT 556
FT /note="S -> P (in Ref. 1; BAB70964)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 569 AA; 66033 MW; 6B0448281129F0E0 CRC64;
MSKDLVTFGD VAVNFSQEEW EWLNPAQRNL YRKVMLENYR SLVSLGVSVS KPDVISLLEQ
GKEPWMVKKE GTRGPCPDWE YVFKNSEFSS KQETYEESSK VVTVGARHLS YSLDYPSLRE
DCQSEDWYKN QLGSQEVHLS QLIITHKEIL PEVQNKEYNK SWQTFHQDTI FDIQQSFPTK
EKAHKHEPQK KSYRKKSVEM KHRKVYVEKK LLKCNDCEKV FNQSSSLTLH QRIHTGEKPY
ACVECGKTFS QSANLAQHKR IHTGEKPYEC KECRKAFSQN AHLAQHQRVH TGEKPYQCKE
CKKAFSQIAH LTQHQRVHTG ERPFECIECG KAFSNGSFLA QHQRIHTGEK PYVCNVCGKA
FSHRGYLIVH QRIHTGERPY ECKECRKAFS QYAHLAQHQR VHTGEKPYEC KVCRKAFSQI
AYLDQHQRVH TGEKPYECIE CGKAFSNSSS LAQHQRSHTG EKPYMCKECR KTFSQNAGLA
QHQRIHTGEK PYECNVCGKA FSYSGSLTLH QRIHTGERPY ECKDCRKSFR QRAHLAHHER
IHTMESFLTL SSPSPSTSNQ LPRPVGFIS
