ZN583_MOUSE
ID ZN583_MOUSE Reviewed; 568 AA.
AC Q3V080; Q3V3L4;
DT 06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 11-OCT-2005, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Zinc finger protein 583;
GN Name=Znf583; Synonyms=Zfp583;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=C57BL/6J; TISSUE=Hypothalamus, and Testis;
RX PubMed=16141072; DOI=10.1126/science.1112014;
RA Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT "The transcriptional landscape of the mammalian genome.";
RL Science 309:1559-1563(2005).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK038614; BAE20539.1; -; mRNA.
DR EMBL; AK133380; BAE21624.1; -; mRNA.
DR CCDS; CCDS39751.1; -.
DR RefSeq; NP_001028421.1; NM_001033249.3.
DR RefSeq; XP_011248777.1; XM_011250475.2.
DR AlphaFoldDB; Q3V080; -.
DR SMR; Q3V080; -.
DR STRING; 10090.ENSMUSP00000053935; -.
DR iPTMnet; Q3V080; -.
DR PhosphoSitePlus; Q3V080; -.
DR PaxDb; Q3V080; -.
DR PRIDE; Q3V080; -.
DR Antibodypedia; 33209; 123 antibodies from 18 providers.
DR Ensembl; ENSMUST00000062765; ENSMUSP00000053935; ENSMUSG00000030443.
DR Ensembl; ENSMUST00000108560; ENSMUSP00000104200; ENSMUSG00000030443.
DR Ensembl; ENSMUST00000165705; ENSMUSP00000129551; ENSMUSG00000030443.
DR GeneID; 213011; -.
DR KEGG; mmu:213011; -.
DR UCSC; uc009fbc.2; mouse.
DR CTD; 213011; -.
DR MGI; MGI:2682297; Zfp583.
DR VEuPathDB; HostDB:ENSMUSG00000030443; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000161925; -.
DR HOGENOM; CLU_002678_44_3_1; -.
DR InParanoid; Q3V080; -.
DR OMA; RVHKHEP; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q3V080; -.
DR TreeFam; TF341817; -.
DR Reactome; R-MMU-212436; Generic Transcription Pathway.
DR BioGRID-ORCS; 213011; 0 hits in 72 CRISPR screens.
DR PRO; PR:Q3V080; -.
DR Proteomes; UP000000589; Chromosome 7.
DR RNAct; Q3V080; protein.
DR Bgee; ENSMUSG00000030443; Expressed in humerus cartilage element and 105 other tissues.
DR ExpressionAtlas; Q3V080; baseline and differential.
DR Genevisible; Q3V080; MM.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..568
FT /note="Zinc finger protein 583"
FT /id="PRO_0000047675"
FT DOMAIN 6..77
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 211..233
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 239..261
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 267..289
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 295..317
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 323..345
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 351..373
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 379..401
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 407..429
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 435..457
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 463..485
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 491..513
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 519..541
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
SQ SEQUENCE 568 AA; 65709 MW; 32640CB4CBEDA2E5 CRC64;
MSKNLLTFED VSVNFTQEEW QWLSDTQRDL YRKVTLENYK SLVSLGIPVY KPAVISLLEQ
GKDPWMVQKK GARDTCPDWQ YVFKGTEFIS KQDIYKESAK VLTMGRSHFS SSLDCPDLKE
DHENEDWFKN RLGRQEVHSH QLFITHKEVP ESEIRGCNPS CQAVHQNAIL DVPQCSSTKE
RIDQSEPQKR SYRKKSVEMK HKKVQVEKRI LKCSECEKVF NQTSSLTLHQ RIHTGEKPYA
CVECGKAFSQ SANLAQHKRI HTGEKPYECK ECRKAFSQNA HLAQHQRVHT GEKPYQCKEC
KKAFSQIAHL TQHQRIHTGE RPFECIECGK AFSNGSFLAQ HQRIHTGEKP YVCHVCGKAF
SHRGYLIVHQ RIHTGERPYE CKECRKSFSQ YAHLSQHQRV HTGEKPYECK VCRKAFSQVA
YLDQHQRVHT GEKPYECAEC RKAFSNSSSL AQHQRSHTGE KPYICKECRK TFSQNAGLAQ
HQRIHTGEKP YECNICGKAF SYSGSLTLHQ RIHTGERPYE CKDCRKSFRQ RAHLAHHEKV
HTMESFLSLS SPSPSMSSQL PRTLGLIS
