ZN584_HUMAN
ID ZN584_HUMAN Reviewed; 421 AA.
AC Q8IVC4; A8K203;
DT 23-NOV-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2003, sequence version 1.
DT 03-AUG-2022, entry version 147.
DE RecName: Full=Zinc finger protein 584;
GN Name=ZNF584;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ALA-301.
RC TISSUE=Substantia nigra;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK290068; BAF82757.1; -; mRNA.
DR EMBL; BC033149; AAH33149.1; -; mRNA.
DR CCDS; CCDS12979.1; -.
DR RefSeq; NP_001304931.1; NM_001318002.1.
DR RefSeq; NP_775819.1; NM_173548.2.
DR AlphaFoldDB; Q8IVC4; -.
DR SMR; Q8IVC4; -.
DR BioGRID; 128391; 10.
DR IntAct; Q8IVC4; 2.
DR STRING; 9606.ENSP00000306756; -.
DR iPTMnet; Q8IVC4; -.
DR PhosphoSitePlus; Q8IVC4; -.
DR BioMuta; ZNF584; -.
DR DMDM; 55976735; -.
DR MassIVE; Q8IVC4; -.
DR MaxQB; Q8IVC4; -.
DR PaxDb; Q8IVC4; -.
DR PeptideAtlas; Q8IVC4; -.
DR PRIDE; Q8IVC4; -.
DR ProteomicsDB; 70680; -.
DR Antibodypedia; 21593; 45 antibodies from 15 providers.
DR DNASU; 201514; -.
DR Ensembl; ENST00000306910.9; ENSP00000306756.3; ENSG00000171574.18.
DR GeneID; 201514; -.
DR KEGG; hsa:201514; -.
DR MANE-Select; ENST00000306910.9; ENSP00000306756.3; NM_173548.3; NP_775819.1.
DR UCSC; uc002qsp.4; human.
DR CTD; 201514; -.
DR DisGeNET; 201514; -.
DR GeneCards; ZNF584; -.
DR HGNC; HGNC:27318; ZNF584.
DR HPA; ENSG00000171574; Low tissue specificity.
DR neXtProt; NX_Q8IVC4; -.
DR OpenTargets; ENSG00000171574; -.
DR PharmGKB; PA134968861; -.
DR VEuPathDB; HostDB:ENSG00000171574; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163291; -.
DR HOGENOM; CLU_002678_0_9_1; -.
DR InParanoid; Q8IVC4; -.
DR OMA; FKYSHSF; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8IVC4; -.
DR TreeFam; TF337055; -.
DR PathwayCommons; Q8IVC4; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8IVC4; -.
DR BioGRID-ORCS; 201514; 16 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF584; human.
DR GenomeRNAi; 201514; -.
DR Pharos; Q8IVC4; Tdark.
DR PRO; PR:Q8IVC4; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8IVC4; protein.
DR Bgee; ENSG00000171574; Expressed in oocyte and 136 other tissues.
DR ExpressionAtlas; Q8IVC4; baseline and differential.
DR Genevisible; Q8IVC4; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 6.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 8.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 5.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 8.
PE 2: Evidence at transcript level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..421
FT /note="Zinc finger protein 584"
FT /id="PRO_0000047676"
FT DOMAIN 17..88
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 159..181
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 214..236
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 242..264
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 270..292
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 298..320
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 326..348
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 354..376
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 382..404
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 120..146
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 402..421
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 120..136
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VARIANT 142
FT /note="P -> S (in dbSNP:rs11668789)"
FT /id="VAR_033579"
FT VARIANT 301
FT /note="T -> A (in dbSNP:rs7257872)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_033580"
SQ SEQUENCE 421 AA; 48272 MW; 76E20EC71CEE8685 CRC64;
MAGEAEAQLD PSLQGLVMFE DVTVYFSREE WGLLNVTQKG LYRDVMLENF ALVSSLGLAP
SRSPVFTQLE DDEQSWVPSW VDVTPVSRAE ARRGFGLDGL CRVEDERAHP EHLKSYRVIQ
HQDTHSEGKP RRHTEHGAAF PPGSSCGQQQ EVHVAEKLFK CSDCGKVFLK AFALLDHLIT
HSEERPFRCP TGRSAFKKSA HINPRKIHTG ETAHVCNECG KAFSYPSKLR KHQKVHTGIK
PFKCSDCGKT FNRKDALVLH QRIHTGERPY ECSKCGKTFS VLSTLIRHRK VHIGERPYEC
TECGKFFKYN NSFILHQRVH TGERPFECKQ CGKGYVTRSG LYQHWKVHTG ERPYECSLCG
KTFTTRSYRN RHQQFHTEER SYECTECGKA FKHSSTLLQH KKVHTPERRQ EDRAHGKVVS
C
