ZN586_HUMAN
ID ZN586_HUMAN Reviewed; 402 AA.
AC Q9NXT0; A0JLV8; A8MY63; B3KTS9; E7ERT1; G3XAH3;
DT 27-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 25-NOV-2008, sequence version 2.
DT 03-AUG-2022, entry version 154.
DE RecName: Full=Zinc finger protein 586;
GN Name=ZNF586;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3).
RC TISSUE=Colon, and Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q9NXT0-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q9NXT0-2; Sequence=VSP_043420, VSP_043421;
CC Name=3;
CC IsoId=Q9NXT0-3; Sequence=VSP_044808;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=BAA90930.1; Type=Frameshift; Evidence={ECO:0000305};
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DR EMBL; AK000077; BAA90930.1; ALT_FRAME; mRNA.
DR EMBL; AK095993; BAG53191.1; -; mRNA.
DR EMBL; AK302151; BAG63522.1; -; mRNA.
DR EMBL; AC003006; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010645; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC093037; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72533.1; -; Genomic_DNA.
DR EMBL; CH471135; EAW72534.1; -; Genomic_DNA.
DR EMBL; BC124558; AAI24559.2; -; mRNA.
DR CCDS; CCDS42640.1; -. [Q9NXT0-1]
DR CCDS; CCDS56107.1; -. [Q9NXT0-2]
DR CCDS; CCDS56108.1; -. [Q9NXT0-3]
DR RefSeq; NP_001070894.1; NM_001077426.2. [Q9NXT0-2]
DR RefSeq; NP_001191743.1; NM_001204814.1. [Q9NXT0-3]
DR RefSeq; NP_060122.2; NM_017652.3. [Q9NXT0-1]
DR AlphaFoldDB; Q9NXT0; -.
DR SMR; Q9NXT0; -.
DR BioGRID; 120164; 4.
DR IntAct; Q9NXT0; 4.
DR STRING; 9606.ENSP00000379458; -.
DR iPTMnet; Q9NXT0; -.
DR PhosphoSitePlus; Q9NXT0; -.
DR BioMuta; ZNF586; -.
DR DMDM; 215273915; -.
DR MassIVE; Q9NXT0; -.
DR MaxQB; Q9NXT0; -.
DR PaxDb; Q9NXT0; -.
DR PeptideAtlas; Q9NXT0; -.
DR PRIDE; Q9NXT0; -.
DR ProteomicsDB; 33749; -.
DR ProteomicsDB; 83134; -. [Q9NXT0-1]
DR ProteomicsDB; 83135; -. [Q9NXT0-2]
DR Antibodypedia; 52690; 63 antibodies from 12 providers.
DR DNASU; 54807; -.
DR Ensembl; ENST00000391702.3; ENSP00000375583.3; ENSG00000083828.16. [Q9NXT0-3]
DR Ensembl; ENST00000396150.4; ENSP00000379454.3; ENSG00000083828.16. [Q9NXT0-2]
DR Ensembl; ENST00000396154.7; ENSP00000379458.1; ENSG00000083828.16. [Q9NXT0-1]
DR GeneID; 54807; -.
DR KEGG; hsa:54807; -.
DR MANE-Select; ENST00000396154.7; ENSP00000379458.1; NM_017652.4; NP_060122.2.
DR UCSC; uc002qqd.4; human. [Q9NXT0-1]
DR CTD; 54807; -.
DR GeneCards; ZNF586; -.
DR HGNC; HGNC:25949; ZNF586.
DR HPA; ENSG00000083828; Low tissue specificity.
DR neXtProt; NX_Q9NXT0; -.
DR OpenTargets; ENSG00000083828; -.
DR PharmGKB; PA134946358; -.
DR VEuPathDB; HostDB:ENSG00000083828; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164743; -.
DR HOGENOM; CLU_002678_2_1_1; -.
DR InParanoid; Q9NXT0; -.
DR OMA; HICTRER; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q9NXT0; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q9NXT0; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q9NXT0; -.
DR BioGRID-ORCS; 54807; 13 hits in 1099 CRISPR screens.
DR ChiTaRS; ZNF586; human.
DR GenomeRNAi; 54807; -.
DR Pharos; Q9NXT0; Tdark.
DR PRO; PR:Q9NXT0; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q9NXT0; protein.
DR Bgee; ENSG00000083828; Expressed in secondary oocyte and 133 other tissues.
DR ExpressionAtlas; Q9NXT0; baseline and differential.
DR Genevisible; Q9NXT0; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 8.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 10.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 8.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 10.
PE 2: Evidence at transcript level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..402
FT /note="Zinc finger protein 586"
FT /id="PRO_0000241449"
FT DOMAIN 15..87
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 88..116
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 122..144
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 150..172
FT /note="C2H2-type 3; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 178..200
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 206..228
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 234..256
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 262..284
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 290..312
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 317..339
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 345..367
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 373..395
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..43
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_044808"
FT VAR_SEQ 13..210
FT /note="SSVTFEDVAVNFSLEEWSLLNEAQRCLYRDVMLETLTLISSLGCWHGGEDEA
FT APSKQSTCIHIYKDQGGHSGERPYECGEYRKLFKNKSCLTEPRRDHKHRNVRTGERPYE
FT CSKYGKLFHQKPTLHIHERFHTGQKTYECSECGKSFHQSSSLLQRQTLHTRERPYECIE
FT CGKAFAEKSSLINHRKVHSGAKRYECNE -> VVGMEGKMRQHLLSRARVYIYTKTREV
FT IVEKGLMSVGNIGNYLRTSPASLNPEEITNTGMFALEKGLMSAANMGNYFTKSLHSIFM
FT RDFILGKRPMSAVSVENHFTKALHSCSVRHFTLEKGLMSVLNVGKPLLKSPVSLTTGKF
FT TLEQSVMNAMNVGSPLLIHLVSLNTGGFTLERGLMSAVNVGDPLLKTPVLLNT (in
FT isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043420"
FT VAR_SEQ 211..402
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:15489334"
FT /id="VSP_043421"
FT CONFLICT 306
FT /note="I -> T (in Ref. 1; BAG63522)"
FT /evidence="ECO:0000305"
FT CONFLICT 370
FT /note="E -> G (in Ref. 1; BAA90930)"
FT /evidence="ECO:0000305"
FT CONFLICT 393
FT /note="R -> G (in Ref. 1; BAA90930)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 402 AA; 46413 MW; FC2A189A0A0E696E CRC64;
MAAAAALRAP AQSSVTFEDV AVNFSLEEWS LLNEAQRCLY RDVMLETLTL ISSLGCWHGG
EDEAAPSKQS TCIHIYKDQG GHSGERPYEC GEYRKLFKNK SCLTEPRRDH KHRNVRTGER
PYECSKYGKL FHQKPTLHIH ERFHTGQKTY ECSECGKSFH QSSSLLQRQT LHTRERPYEC
IECGKAFAEK SSLINHRKVH SGAKRYECNE CGKSFAYTSS LIKHRRIHTG ERPYECSECG
RSFAENSSLI KHLRVHTGER PYECVECGKS FRRSSSLLQH QRVHTRERPY ECSECGKSFS
LRSNLIHHQR VHTGERHECG QCGKSFSRKS SLIIHLRVHT GERPYECSDC GKSFAENSSL
IKHLRVHTGE RPYECIDCGK SFRHSSSFRR HQRVHTGMRP YK
