ZN587_HUMAN
ID ZN587_HUMAN Reviewed; 575 AA.
AC Q96SQ5; A0AV72; G3V0H5; Q6ZMK8;
DT 02-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-DEC-2001, sequence version 1.
DT 03-AUG-2022, entry version 162.
DE RecName: Full=Zinc finger protein 587;
GN Name=ZNF587;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Teratocarcinoma;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 12-575.
RC TISSUE=Spleen;
RA Jikuya H., Takano J., Nomura N., Kikuno R., Nagase T., Ohara O.;
RT "The nucleotide sequence of a long cDNA clone isolated from human spleen.";
RL Submitted (APR-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96SQ5; Q6UY14-3: ADAMTSL4; NbExp=3; IntAct=EBI-6427977, EBI-10173507;
CC Q96SQ5; Q13520: AQP6; NbExp=3; IntAct=EBI-6427977, EBI-13059134;
CC Q96SQ5; Q8WXK1: ASB15; NbExp=3; IntAct=EBI-6427977, EBI-12809012;
CC Q96SQ5; Q9NWX5: ASB6; NbExp=3; IntAct=EBI-6427977, EBI-6425205;
CC Q96SQ5; Q9Y2T1: AXIN2; NbExp=3; IntAct=EBI-6427977, EBI-4400025;
CC Q96SQ5; Q9BUH8: BEGAIN; NbExp=3; IntAct=EBI-6427977, EBI-742722;
CC Q96SQ5; Q8WW18: C17orf50; NbExp=3; IntAct=EBI-6427977, EBI-12877892;
CC Q96SQ5; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-6427977, EBI-3866279;
CC Q96SQ5; Q9H257: CARD9; NbExp=3; IntAct=EBI-6427977, EBI-751319;
CC Q96SQ5; Q9H257-2: CARD9; NbExp=3; IntAct=EBI-6427977, EBI-11530605;
CC Q96SQ5; Q86Z20: CCDC125; NbExp=3; IntAct=EBI-6427977, EBI-11977221;
CC Q96SQ5; Q96JN2-2: CCDC136; NbExp=3; IntAct=EBI-6427977, EBI-10171416;
CC Q96SQ5; Q15834: CCDC85B; NbExp=3; IntAct=EBI-6427977, EBI-739674;
CC Q96SQ5; Q9C0F1: CEP44; NbExp=6; IntAct=EBI-6427977, EBI-744115;
CC Q96SQ5; Q8NHQ1: CEP70; NbExp=6; IntAct=EBI-6427977, EBI-739624;
CC Q96SQ5; Q6WN34-2: CHRDL2; NbExp=3; IntAct=EBI-6427977, EBI-12593838;
CC Q96SQ5; Q96S65: CSRNP1; NbExp=3; IntAct=EBI-6427977, EBI-4311573;
CC Q96SQ5; A8MQ03: CYSRT1; NbExp=3; IntAct=EBI-6427977, EBI-3867333;
CC Q96SQ5; Q6ZN54-2: DEF8; NbExp=3; IntAct=EBI-6427977, EBI-12346463;
CC Q96SQ5; Q6P158: DHX57; NbExp=3; IntAct=EBI-6427977, EBI-1051531;
CC Q96SQ5; O95967: EFEMP2; NbExp=3; IntAct=EBI-6427977, EBI-743414;
CC Q96SQ5; O94868-3: FCHSD2; NbExp=3; IntAct=EBI-6427977, EBI-11958845;
CC Q96SQ5; Q13643: FHL3; NbExp=3; IntAct=EBI-6427977, EBI-741101;
CC Q96SQ5; Q5TD97: FHL5; NbExp=3; IntAct=EBI-6427977, EBI-750641;
CC Q96SQ5; A1L4K1: FSD2; NbExp=6; IntAct=EBI-6427977, EBI-5661036;
CC Q96SQ5; P19883: FST; NbExp=3; IntAct=EBI-6427977, EBI-1571188;
CC Q96SQ5; Q08379: GOLGA2; NbExp=3; IntAct=EBI-6427977, EBI-618309;
CC Q96SQ5; A6NEM1: GOLGA6L9; NbExp=3; IntAct=EBI-6427977, EBI-5916454;
CC Q96SQ5; Q9HD26: GOPC; NbExp=3; IntAct=EBI-6427977, EBI-349832;
CC Q96SQ5; O15499: GSC2; NbExp=3; IntAct=EBI-6427977, EBI-19954058;
CC Q96SQ5; Q6NT76: HMBOX1; NbExp=3; IntAct=EBI-6427977, EBI-2549423;
CC Q96SQ5; Q96ED9-2: HOOK2; NbExp=3; IntAct=EBI-6427977, EBI-10961706;
CC Q96SQ5; P49639: HOXA1; NbExp=5; IntAct=EBI-6427977, EBI-740785;
CC Q96SQ5; O75031: HSF2BP; NbExp=3; IntAct=EBI-6427977, EBI-7116203;
CC Q96SQ5; P24592: IGFBP6; NbExp=3; IntAct=EBI-6427977, EBI-947015;
CC Q96SQ5; Q9Y6K9: IKBKG; NbExp=3; IntAct=EBI-6427977, EBI-81279;
CC Q96SQ5; Q13422-7: IKZF1; NbExp=3; IntAct=EBI-6427977, EBI-11522367;
CC Q96SQ5; Q9UKT9: IKZF3; NbExp=3; IntAct=EBI-6427977, EBI-747204;
CC Q96SQ5; Q1MX18: INSC; NbExp=3; IntAct=EBI-6427977, EBI-12081118;
CC Q96SQ5; Q9ULR0-1: ISY1; NbExp=3; IntAct=EBI-6427977, EBI-18398632;
CC Q96SQ5; Q9H079: KATNBL1; NbExp=3; IntAct=EBI-6427977, EBI-715394;
CC Q96SQ5; Q96MP8-2: KCTD7; NbExp=3; IntAct=EBI-6427977, EBI-11954971;
CC Q96SQ5; Q5T749: KPRP; NbExp=3; IntAct=EBI-6427977, EBI-10981970;
CC Q96SQ5; Q15323: KRT31; NbExp=3; IntAct=EBI-6427977, EBI-948001;
CC Q96SQ5; O76015: KRT38; NbExp=3; IntAct=EBI-6427977, EBI-1047263;
CC Q96SQ5; Q6A162: KRT40; NbExp=6; IntAct=EBI-6427977, EBI-10171697;
CC Q96SQ5; Q07627: KRTAP1-1; NbExp=3; IntAct=EBI-6427977, EBI-11959885;
CC Q96SQ5; Q8IUG1: KRTAP1-3; NbExp=3; IntAct=EBI-6427977, EBI-11749135;
CC Q96SQ5; P60014: KRTAP10-10; NbExp=3; IntAct=EBI-6427977, EBI-11955579;
CC Q96SQ5; P60412: KRTAP10-11; NbExp=3; IntAct=EBI-6427977, EBI-10217483;
CC Q96SQ5; P60370: KRTAP10-5; NbExp=6; IntAct=EBI-6427977, EBI-10172150;
CC Q96SQ5; P60409: KRTAP10-7; NbExp=6; IntAct=EBI-6427977, EBI-10172290;
CC Q96SQ5; P60410: KRTAP10-8; NbExp=6; IntAct=EBI-6427977, EBI-10171774;
CC Q96SQ5; P60411: KRTAP10-9; NbExp=6; IntAct=EBI-6427977, EBI-10172052;
CC Q96SQ5; P59991: KRTAP12-2; NbExp=3; IntAct=EBI-6427977, EBI-10176379;
CC Q96SQ5; P60328: KRTAP12-3; NbExp=3; IntAct=EBI-6427977, EBI-11953334;
CC Q96SQ5; P0C7H8: KRTAP2-3; NbExp=3; IntAct=EBI-6427977, EBI-10196781;
CC Q96SQ5; Q9BYR9: KRTAP2-4; NbExp=3; IntAct=EBI-6427977, EBI-14065470;
CC Q96SQ5; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-6427977, EBI-11987425;
CC Q96SQ5; P26371: KRTAP5-9; NbExp=6; IntAct=EBI-6427977, EBI-3958099;
CC Q96SQ5; O95751: LDOC1; NbExp=3; IntAct=EBI-6427977, EBI-740738;
CC Q96SQ5; Q9UBR4-2: LHX3; NbExp=3; IntAct=EBI-6427977, EBI-12039345;
CC Q96SQ5; P48059-3: LIMS1; NbExp=3; IntAct=EBI-6427977, EBI-12864460;
CC Q96SQ5; Q8TAP4-4: LMO3; NbExp=3; IntAct=EBI-6427977, EBI-11742507;
CC Q96SQ5; Q9P2M1: LRP2BP; NbExp=3; IntAct=EBI-6427977, EBI-18273118;
CC Q96SQ5; Q9Y250: LZTS1; NbExp=3; IntAct=EBI-6427977, EBI-1216080;
CC Q96SQ5; P59942: MCCD1; NbExp=3; IntAct=EBI-6427977, EBI-11987923;
CC Q96SQ5; Q99750: MDFI; NbExp=8; IntAct=EBI-6427977, EBI-724076;
CC Q96SQ5; P50222: MEOX2; NbExp=3; IntAct=EBI-6427977, EBI-748397;
CC Q96SQ5; Q6FHY5: MEOX2; NbExp=3; IntAct=EBI-6427977, EBI-16439278;
CC Q96SQ5; Q9UJV3-2: MID2; NbExp=6; IntAct=EBI-6427977, EBI-10172526;
CC Q96SQ5; Q13064: MKRN3; NbExp=3; IntAct=EBI-6427977, EBI-2340269;
CC Q96SQ5; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-6427977, EBI-742948;
CC Q96SQ5; Q5JR59-3: MTUS2; NbExp=5; IntAct=EBI-6427977, EBI-11522433;
CC Q96SQ5; P13349: MYF5; NbExp=5; IntAct=EBI-6427977, EBI-17491620;
CC Q96SQ5; P17568: NDUFB7; NbExp=3; IntAct=EBI-6427977, EBI-1246238;
CC Q96SQ5; Q9HC98-4: NEK6; NbExp=3; IntAct=EBI-6427977, EBI-11750983;
CC Q96SQ5; Q5M9Q1: NKAPL; NbExp=3; IntAct=EBI-6427977, EBI-11423380;
CC Q96SQ5; Q7Z3S9: NOTCH2NLA; NbExp=3; IntAct=EBI-6427977, EBI-945833;
CC Q96SQ5; P0DPK4: NOTCH2NLC; NbExp=3; IntAct=EBI-6427977, EBI-22310682;
CC Q96SQ5; Q6NSM0: NR1D2; NbExp=3; IntAct=EBI-6427977, EBI-10250949;
CC Q96SQ5; P40425: PBX2; NbExp=3; IntAct=EBI-6427977, EBI-348489;
CC Q96SQ5; Q5VU43-2: PDE4DIP; NbExp=3; IntAct=EBI-6427977, EBI-9640281;
CC Q96SQ5; O15162: PLSCR1; NbExp=3; IntAct=EBI-6427977, EBI-740019;
CC Q96SQ5; Q9UL42: PNMA2; NbExp=6; IntAct=EBI-6427977, EBI-302355;
CC Q96SQ5; Q9GZV8: PRDM14; NbExp=3; IntAct=EBI-6427977, EBI-3957793;
CC Q96SQ5; Q8WWY3: PRPF31; NbExp=6; IntAct=EBI-6427977, EBI-1567797;
CC Q96SQ5; Q92753-1: RORB; NbExp=3; IntAct=EBI-6427977, EBI-18560266;
CC Q96SQ5; Q59EK9: RUNDC3A; NbExp=3; IntAct=EBI-6427977, EBI-747225;
CC Q96SQ5; Q59EK9-3: RUNDC3A; NbExp=3; IntAct=EBI-6427977, EBI-11957366;
CC Q96SQ5; Q6GMV2: SMYD5; NbExp=3; IntAct=EBI-6427977, EBI-11057552;
CC Q96SQ5; Q9UN79: SOX13; NbExp=3; IntAct=EBI-6427977, EBI-3928516;
CC Q96SQ5; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-6427977, EBI-5235340;
CC Q96SQ5; O43597: SPRY2; NbExp=3; IntAct=EBI-6427977, EBI-742487;
CC Q96SQ5; O43610: SPRY3; NbExp=3; IntAct=EBI-6427977, EBI-12290641;
CC Q96SQ5; Q9Y2D8: SSX2IP; NbExp=3; IntAct=EBI-6427977, EBI-2212028;
CC Q96SQ5; O75558: STX11; NbExp=8; IntAct=EBI-6427977, EBI-714135;
CC Q96SQ5; P15884: TCF4; NbExp=3; IntAct=EBI-6427977, EBI-533224;
CC Q96SQ5; P15884-3: TCF4; NbExp=3; IntAct=EBI-6427977, EBI-13636688;
CC Q96SQ5; Q6N022: TENM4; NbExp=3; IntAct=EBI-6427977, EBI-12827077;
CC Q96SQ5; Q9UBB9: TFIP11; NbExp=3; IntAct=EBI-6427977, EBI-1105213;
CC Q96SQ5; Q63HR2: TNS2; NbExp=6; IntAct=EBI-6427977, EBI-949753;
CC Q96SQ5; Q13077: TRAF1; NbExp=6; IntAct=EBI-6427977, EBI-359224;
CC Q96SQ5; Q96RU7: TRIB3; NbExp=3; IntAct=EBI-6427977, EBI-492476;
CC Q96SQ5; P36406: TRIM23; NbExp=3; IntAct=EBI-6427977, EBI-740098;
CC Q96SQ5; P14373: TRIM27; NbExp=3; IntAct=EBI-6427977, EBI-719493;
CC Q96SQ5; Q9NQ86: TRIM36; NbExp=3; IntAct=EBI-6427977, EBI-2341518;
CC Q96SQ5; O94972: TRIM37; NbExp=3; IntAct=EBI-6427977, EBI-741602;
CC Q96SQ5; Q8WV44: TRIM41; NbExp=6; IntAct=EBI-6427977, EBI-725997;
CC Q96SQ5; Q9BYV2: TRIM54; NbExp=6; IntAct=EBI-6427977, EBI-2130429;
CC Q96SQ5; Q86WV8: TSC1; NbExp=3; IntAct=EBI-6427977, EBI-12806590;
CC Q96SQ5; Q9BZW7: TSGA10; NbExp=3; IntAct=EBI-6427977, EBI-744794;
CC Q96SQ5; P42681: TXK; NbExp=3; IntAct=EBI-6427977, EBI-7877438;
CC Q96SQ5; Q8N1B4: VPS52; NbExp=3; IntAct=EBI-6427977, EBI-2799833;
CC Q96SQ5; Q2TAL6: VWC2; NbExp=3; IntAct=EBI-6427977, EBI-11957238;
CC Q96SQ5; O43298: ZBTB43; NbExp=3; IntAct=EBI-6427977, EBI-740718;
CC Q96SQ5; Q96BR9: ZBTB8A; NbExp=6; IntAct=EBI-6427977, EBI-742740;
CC Q96SQ5; Q8N5A5-2: ZGPAT; NbExp=3; IntAct=EBI-6427977, EBI-10183064;
CC Q96SQ5; Q9NZV7: ZIM2; NbExp=3; IntAct=EBI-6427977, EBI-11962760;
CC Q96SQ5; Q15776: ZKSCAN8; NbExp=3; IntAct=EBI-6427977, EBI-2602314;
CC Q96SQ5; Q9HBT8: ZNF286A; NbExp=3; IntAct=EBI-6427977, EBI-10754950;
CC Q96SQ5; Q9Y3S2: ZNF330; NbExp=3; IntAct=EBI-6427977, EBI-373456;
CC Q96SQ5; Q8TAU3: ZNF417; NbExp=3; IntAct=EBI-6427977, EBI-740727;
CC Q96SQ5; Q8IVP9: ZNF547; NbExp=3; IntAct=EBI-6427977, EBI-12895421;
CC Q96SQ5; Q6NX45: ZNF774; NbExp=3; IntAct=EBI-6427977, EBI-10251462;
CC Q96SQ5; Q3KNS6-3: ZNF829; NbExp=3; IntAct=EBI-6427977, EBI-18036029;
CC Q96SQ5; Q96EG3: ZNF837; NbExp=3; IntAct=EBI-6427977, EBI-11962574;
CC Q96SQ5; Q9UGI0: ZRANB1; NbExp=3; IntAct=EBI-6427977, EBI-527853;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q96SQ5-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96SQ5-2; Sequence=VSP_046842;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AK027616; BAB55235.1; -; mRNA.
DR EMBL; AC010326; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AC010522; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72537.1; -; Genomic_DNA.
DR EMBL; BC126237; AAI26238.1; -; mRNA.
DR EMBL; BC126239; AAI26240.1; -; mRNA.
DR EMBL; AK160374; BAD18717.1; -; mRNA.
DR CCDS; CCDS12964.1; -. [Q96SQ5-1]
DR CCDS; CCDS56110.1; -. [Q96SQ5-2]
DR RefSeq; NP_001191746.1; NM_001204817.1. [Q96SQ5-2]
DR RefSeq; NP_116217.1; NM_032828.3. [Q96SQ5-1]
DR AlphaFoldDB; Q96SQ5; -.
DR SMR; Q96SQ5; -.
DR BioGRID; 124351; 130.
DR IntAct; Q96SQ5; 127.
DR STRING; 9606.ENSP00000345479; -.
DR iPTMnet; Q96SQ5; -.
DR PhosphoSitePlus; Q96SQ5; -.
DR BioMuta; ZNF587; -.
DR DMDM; 74762694; -.
DR EPD; Q96SQ5; -.
DR MassIVE; Q96SQ5; -.
DR MaxQB; Q96SQ5; -.
DR PaxDb; Q96SQ5; -.
DR PeptideAtlas; Q96SQ5; -.
DR PRIDE; Q96SQ5; -.
DR ProteomicsDB; 32198; -.
DR ProteomicsDB; 78135; -. [Q96SQ5-1]
DR Antibodypedia; 33305; 62 antibodies from 16 providers.
DR DNASU; 84914; -.
DR Ensembl; ENST00000339656.8; ENSP00000345479.4; ENSG00000198466.12. [Q96SQ5-1]
DR Ensembl; ENST00000423137.1; ENSP00000393865.1; ENSG00000198466.12. [Q96SQ5-2]
DR GeneID; 84914; -.
DR KEGG; hsa:84914; -.
DR MANE-Select; ENST00000339656.8; ENSP00000345479.4; NM_032828.4; NP_116217.1.
DR UCSC; uc002qql.4; human. [Q96SQ5-1]
DR CTD; 84914; -.
DR GeneCards; ZNF587; -.
DR HGNC; HGNC:30955; ZNF587.
DR HPA; ENSG00000198466; Low tissue specificity.
DR neXtProt; NX_Q96SQ5; -.
DR OpenTargets; ENSG00000198466; -.
DR PharmGKB; PA134940421; -.
DR VEuPathDB; HostDB:ENSG00000198466; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164176; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q96SQ5; -.
DR OMA; GHTGECK; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96SQ5; -.
DR TreeFam; TF339848; -.
DR PathwayCommons; Q96SQ5; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96SQ5; -.
DR BioGRID-ORCS; 84914; 19 hits in 1011 CRISPR screens.
DR ChiTaRS; ZNF587; human.
DR GenomeRNAi; 84914; -.
DR Pharos; Q96SQ5; Tbio.
DR PRO; PR:Q96SQ5; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96SQ5; protein.
DR Bgee; ENSG00000198466; Expressed in pylorus and 197 other tissues.
DR Genevisible; Q96SQ5; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 11.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 13.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 13.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..575
FT /note="Zinc finger protein 587"
FT /id="PRO_0000233987"
FT DOMAIN 15..88
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 92..114
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 240..262
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 268..290
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 296..318
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 324..346
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 352..374
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 380..402
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 408..430
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 436..458
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 464..486
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 492..514
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 520..542
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 548..570
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT REGION 69..88
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT VAR_SEQ 11
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000305"
FT /id="VSP_046842"
SQ SEQUENCE 575 AA; 65622 MW; 61134F2814963397 CRC64;
MAAAVPRRPT QQGTVTFEDV AVNFSQEEWC LLSEAQRCLY RDVMLENLAL ISSLGCWCGS
KDEEAPCKQR ISVQRESQSR TPRAGVSPKK AHPCEMCGLI LEDVFHFADH QETHHKQKLN
RSGACGKNLD DTAYLHQHQK QHIGEKFYRK SVREASFVKK RKLRVSQEPF VFREFGKDVL
PSSGLCQEEA AVEKTDSETM HGPPFQEGKT NYSCGKRTKA FSTKHSVIPH QKLFTRDGCY
VCSDCGKSFS RYVSFSNHQR DHTAKGPYDC GECGKSYSRK SSLIQHQRVH TGQTAYPCEE
CGKSFSQKGS LISHQLVHTG EGPYECRECG KSFGQKGNLI QHQQGHTGER AYHCGECGKS
FRQKFCFINH QRVHTGERPY KCGECGKSFG QKGNLVHHQR GHTGERPYEC KECGKSFRYR
SHLTEHQRLH TGERPYNCRE CGKLFNRKYH LLVHERVHTG ERPYACEVCG KLFGNKHSVT
IHQRIHTGER PYECSECGKS FLSSSALHVH KRVHSGQKPY KCSECGKSFS ECSSLIKHRR
IHTGERPYEC TKCGKTFQRS STLLHHQSSH RRKAL
