ID   ZN593_XENTR             Reviewed;         128 AA.
AC   B0BLT0;
DT   29-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=Zinc finger protein 593;
GN   Name=znf593;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in pre-60S ribosomal particles maturation by
CC       promoting the nuclear export of the 60S ribosome. Negatively modulates
CC       the DNA binding activity of Oct-2 and therefore its transcriptional
CC       regulatory activity. {ECO:0000250|UniProtKB:O00488}.
CC   -!- SUBUNIT: Associates with pre-60S ribosomal particles.
CC       {ECO:0000250|UniProtKB:O00488}.
CC   -!- SUBCELLULAR LOCATION: Nucleus, nucleolus
CC       {ECO:0000250|UniProtKB:O00488}. Cytoplasm
CC       {ECO:0000250|UniProtKB:Q08004}. Note=Shuttles between the nucleus and
CC       the cytoplasm. {ECO:0000250|UniProtKB:Q08004}.
CC   -!- DOMAIN: The protein is largely disordered, with the exception of the
CC       zinc finger domain. {ECO:0000250|UniProtKB:O00488}.
CC   -!- SIMILARITY: Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein
CC       family. {ECO:0000305}.
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DR   EMBL; BC158149; AAI58150.1; -; mRNA.
DR   RefSeq; NP_001016550.1; NM_001016550.2.
DR   RefSeq; XP_012812435.1; XM_012956981.2.
DR   RefSeq; XP_012812436.1; XM_012956982.2.
DR   AlphaFoldDB; B0BLT0; -.
DR   SMR; B0BLT0; -.
DR   STRING; 8364.ENSXETP00000059122; -.
DR   PaxDb; B0BLT0; -.
DR   Ensembl; ENSXETT00000020167; ENSXETP00000020167; ENSXETG00000009189.
DR   GeneID; 549304; -.
DR   KEGG; xtr:549304; -.
DR   CTD; 51042; -.
DR   Xenbase; XB-GENE-1217394; znf593.
DR   eggNOG; KOG3408; Eukaryota.
DR   HOGENOM; CLU_117291_1_2_1; -.
DR   InParanoid; B0BLT0; -.
DR   OrthoDB; 1445352at2759; -.
DR   PhylomeDB; B0BLT0; -.
DR   Proteomes; UP000008143; Chromosome 2.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000009189; Expressed in liver and 24 other tissues.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR003604; Matrin/U1-like-C_Znf_C2H2.
DR   InterPro; IPR022755; Znf_C2H2_jaz.
DR   InterPro; IPR036236; Znf_C2H2_sf.
DR   InterPro; IPR013087; Znf_C2H2_type.
DR   Pfam; PF12171; zf-C2H2_jaz; 1.
DR   SMART; SM00451; ZnF_U1; 1.
DR   SUPFAM; SSF57667; SSF57667; 1.
DR   PROSITE; PS00028; ZINC_FINGER_C2H2_1; 1.
DR   PROSITE; PS50157; ZINC_FINGER_C2H2_2; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Metal-binding; Nucleus; Reference proteome; Ribosome biogenesis;
KW   Zinc; Zinc-finger.
FT   CHAIN           1..128
FT                   /note="Zinc finger protein 593"
FT                   /id="PRO_0000331295"
FT   ZN_FING         61..85
FT                   /note="C2H2-type"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT   REGION          1..21
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..15
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   128 AA;  15216 MW;  2A0F2456F8DFC969 CRC64;
     MVRSKQVGNH KSDKKKNISK LWKTKRRVKD LDQIHHDMKP ENAKLLLNQE IDYQLPGNAQ
     HYCLHCSRYF VDLKTLKEHF KTKVHKRRLK QLREEPYTQE EAERAAGMGS YIPPKLINVQ
     TQDTMEMS