CCA11_ARATH
ID CCA11_ARATH Reviewed; 460 AA.
AC Q9C6Y3;
DT 15-MAY-2007, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-2001, sequence version 1.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Cyclin-A1-1;
DE AltName: Full=G2/mitotic-specific cyclin-A1-1;
DE Short=CycA1;1;
GN Name=CYCA1-1; OrderedLocusNames=At1g44110; ORFNames=T7O23.18;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA Totoki Y., Seki M., Ishida J., Nakajima M., Enju A., Kamiya A.,
RA Narusaka M., Shin-i T., Nakagawa M., Sakamoto N., Oishi K., Kohara Y.,
RA Kobayashi M., Toyoda A., Sakaki Y., Sakurai T., Iida K., Akiyama K.,
RA Satou M., Toyoda T., Konagaya A., Carninci P., Kawai J., Hayashizaki Y.,
RA Shinozaki K.;
RT "Large-scale analysis of RIKEN Arabidopsis full-length (RAFL) cDNAs.";
RL Submitted (SEP-2004) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=15208425; DOI=10.1104/pp.104.040436;
RA Wang G., Kong H., Sun Y., Zhang X., Zhang W., Altman N., dePamphilis C.W.,
RA Ma H.;
RT "Genome-wide analysis of the cyclin family in Arabidopsis and comparative
RT phylogenetic analysis of plant cyclin-like proteins.";
RL Plant Physiol. 135:1084-1099(2004).
RN [5]
RP DEVELOPMENTAL STAGE, AND INTERACTION WITH FZR1; FZR2 AND FZR3.
RX PubMed=15970679;
RA Fueloep K., Tarayre S., Kelemen Z., Horvath G., Kevei Z., Nikovics K.,
RA Bako L., Brown S., Kondorosi A., Kondorosi E.;
RT "Arabidopsis anaphase-promoting complexes: multiple activators and wide
RT range of substrates might keep APC perpetually busy.";
RL Cell Cycle 4:1084-1092(2005).
RN [6]
RP DEVELOPMENTAL STAGE.
RX PubMed=16517759; DOI=10.1105/tpc.105.039636;
RA Menges M., Samland A.K., Planchais S., Murray J.A.H.;
RT "The D-type cyclin CYCD3;1 is limiting for the G1-to-S-phase transition in
RT Arabidopsis.";
RL Plant Cell 18:893-906(2006).
CC -!- SUBUNIT: Interacts with FZR2/CCS52A1, FZR1/CCS52A2 and FZR3/CCS52B.
CC {ECO:0000269|PubMed:15970679}.
CC -!- DEVELOPMENTAL STAGE: Expressed in the G2/M phases. Remains high in
CC early G1 phase. {ECO:0000269|PubMed:15970679,
CC ECO:0000269|PubMed:16517759}.
CC -!- SIMILARITY: Belongs to the cyclin family. Cyclin AB subfamily.
CC {ECO:0000305}.
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DR EMBL; AC074228; AAG50557.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE32021.1; -; Genomic_DNA.
DR EMBL; AK175406; BAD43169.1; -; mRNA.
DR PIR; D96505; D96505.
DR RefSeq; NP_175077.1; NM_103537.5.
DR AlphaFoldDB; Q9C6Y3; -.
DR SMR; Q9C6Y3; -.
DR BioGRID; 26239; 11.
DR IntAct; Q9C6Y3; 2.
DR STRING; 3702.AT1G44110.1; -.
DR PaxDb; Q9C6Y3; -.
DR PRIDE; Q9C6Y3; -.
DR ProteomicsDB; 239153; -.
DR EnsemblPlants; AT1G44110.1; AT1G44110.1; AT1G44110.
DR GeneID; 841014; -.
DR Gramene; AT1G44110.1; AT1G44110.1; AT1G44110.
DR KEGG; ath:AT1G44110; -.
DR Araport; AT1G44110; -.
DR TAIR; locus:2205871; AT1G44110.
DR eggNOG; KOG0654; Eukaryota.
DR HOGENOM; CLU_020695_13_2_1; -.
DR InParanoid; Q9C6Y3; -.
DR OMA; MDETMSS; -.
DR OrthoDB; 993640at2759; -.
DR PhylomeDB; Q9C6Y3; -.
DR PRO; PR:Q9C6Y3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9C6Y3; baseline and differential.
DR Genevisible; Q9C6Y3; AT.
DR GO; GO:0000307; C:cyclin-dependent protein kinase holoenzyme complex; IBA:GO_Central.
DR GO; GO:0005737; C:cytoplasm; IDA:TAIR.
DR GO; GO:0005634; C:nucleus; IDA:TAIR.
DR GO; GO:0016538; F:cyclin-dependent protein serine/threonine kinase regulator activity; IBA:GO_Central.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0044772; P:mitotic cell cycle phase transition; IBA:GO_Central.
DR GO; GO:0000079; P:regulation of cyclin-dependent protein serine/threonine kinase activity; IBA:GO_Central.
DR CDD; cd00043; CYCLIN; 2.
DR InterPro; IPR039361; Cyclin.
DR InterPro; IPR013763; Cyclin-like.
DR InterPro; IPR036915; Cyclin-like_sf.
DR InterPro; IPR004367; Cyclin_C-dom.
DR InterPro; IPR006671; Cyclin_N.
DR PANTHER; PTHR10177; PTHR10177; 1.
DR Pfam; PF02984; Cyclin_C; 1.
DR Pfam; PF00134; Cyclin_N; 1.
DR PIRSF; PIRSF001771; Cyclin_A_B_D_E; 1.
DR SMART; SM00385; CYCLIN; 2.
DR SMART; SM01332; Cyclin_C; 1.
DR SUPFAM; SSF47954; SSF47954; 2.
DR PROSITE; PS00292; CYCLINS; 1.
PE 1: Evidence at protein level;
KW Cell cycle; Cell division; Cyclin; Reference proteome.
FT CHAIN 1..460
FT /note="Cyclin-A1-1"
FT /id="PRO_0000286987"
FT REGION 1..52
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 95..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..35
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 460 AA; 51904 MW; FE942F7D2D9F46EA CRC64;
MSNILQNRRS SFSSSTKSSL AKRQAPSSSE NSVKLMPAMT KKRAPLSNIT NQKIASRLQN
SDSVHCSNKS AKLKIAPSVC VNASFSSNLQ QSIVPHKVAS SPSKSDDGSV SMDETRSSSD
SYKSPQVEYI ENDDVSAVVS IERKALSNLF ITPNSETIDN YCSRDVLSDM KKMDKNQIVN
IDSNNGDPQL CATFACDIYK HLRASEAKKR PDVDYMERVQ KDVNSSMRGI LVDWLIEVSE
EYRLVPETLY LTVNYIDRYL SGNVISRQKL QLLGVACMMI AAKYEEICAP QVEEFCYITD
NTYLKDEVLD MESDVLNYLK FEMTAPTTKC FLRRFVRAAH GVHEAPLMQL ECMANYIAEL
SLLEYTMLSH SPSLVAASAI FLAKYILDPT RRPWNSTLQH YTQYKAMELR GCVKDLQRLC
STAHGSTLPA VREKYSQHKY KFVAKKFCPS VIPQEFFNNS
