ZN600_HUMAN
ID ZN600_HUMAN Reviewed; 722 AA.
AC Q6ZNG1; Q6MZR0;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 18-MAY-2010, sequence version 2.
DT 03-AUG-2022, entry version 155.
DE RecName: Full=Zinc finger protein 600;
GN Name=ZNF600;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-209.
RC TISSUE=Amygdala;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], AND VARIANT ARG-209.
RC TISSUE=Uterus;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Leukemic T-cell;
RX PubMed=19690332; DOI=10.1126/scisignal.2000007;
RA Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,
RA Rodionov V., Han D.K.;
RT "Quantitative phosphoproteomic analysis of T cell receptor signaling
RT reveals system-wide modulation of protein-protein interactions.";
RL Sci. Signal. 2:RA46-RA46(2009).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6ZNG1; P60371: KRTAP10-6; NbExp=3; IntAct=EBI-3444696, EBI-12012928;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK131231; BAD18414.1; -; mRNA.
DR EMBL; BX640933; CAE45968.1; -; mRNA.
DR EMBL; AC008813; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR CCDS; CCDS12856.1; -.
DR RefSeq; NP_001308795.1; NM_001321866.1.
DR RefSeq; NP_001308796.1; NM_001321867.1.
DR RefSeq; NP_940859.3; NM_198457.3.
DR AlphaFoldDB; Q6ZNG1; -.
DR SMR; Q6ZNG1; -.
DR BioGRID; 127833; 4.
DR IntAct; Q6ZNG1; 2.
DR STRING; 9606.ENSP00000344791; -.
DR iPTMnet; Q6ZNG1; -.
DR PhosphoSitePlus; Q6ZNG1; -.
DR BioMuta; ZNF600; -.
DR DMDM; 296453048; -.
DR EPD; Q6ZNG1; -.
DR jPOST; Q6ZNG1; -.
DR MassIVE; Q6ZNG1; -.
DR MaxQB; Q6ZNG1; -.
DR PaxDb; Q6ZNG1; -.
DR PeptideAtlas; Q6ZNG1; -.
DR PRIDE; Q6ZNG1; -.
DR ProteomicsDB; 68023; -.
DR Antibodypedia; 56950; 42 antibodies from 17 providers.
DR DNASU; 162966; -.
DR Ensembl; ENST00000338230.3; ENSP00000344791.2; ENSG00000189190.11.
DR GeneID; 162966; -.
DR KEGG; hsa:162966; -.
DR UCSC; uc002qab.5; human.
DR CTD; 162966; -.
DR DisGeNET; 162966; -.
DR GeneCards; ZNF600; -.
DR HGNC; HGNC:30951; ZNF600.
DR HPA; ENSG00000189190; Low tissue specificity.
DR neXtProt; NX_Q6ZNG1; -.
DR OpenTargets; ENSG00000189190; -.
DR PharmGKB; PA134977938; -.
DR VEuPathDB; HostDB:ENSG00000189190; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164431; -.
DR HOGENOM; CLU_002678_17_0_1; -.
DR InParanoid; Q6ZNG1; -.
DR OrthoDB; 925064at2759; -.
DR PhylomeDB; Q6ZNG1; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q6ZNG1; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6ZNG1; -.
DR BioGRID-ORCS; 162966; 9 hits in 1091 CRISPR screens.
DR GenomeRNAi; 162966; -.
DR Pharos; Q6ZNG1; Tdark.
DR PRO; PR:Q6ZNG1; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6ZNG1; protein.
DR Bgee; ENSG00000189190; Expressed in pancreatic ductal cell and 175 other tissues.
DR ExpressionAtlas; Q6ZNG1; baseline and differential.
DR Genevisible; Q6ZNG1; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF00096; zf-C2H2; 13.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF57667; SSF57667; 11.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 20.
PE 1: Evidence at protein level;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..722
FT /note="Zinc finger protein 600"
FT /id="PRO_0000234593"
FT ZN_FING 162..184
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 190..212
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 218..240
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 246..268
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 274..296
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 302..324
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 330..352
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 358..380
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 386..408
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 414..436
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 442..464
FT /note="C2H2-type 11; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 470..492
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 498..520
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 526..548
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 554..576
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 582..604
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 610..632
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 638..660
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 666..688
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 694..716
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VARIANT 2
FT /note="M -> V (in dbSNP:rs7252818)"
FT /id="VAR_057427"
FT VARIANT 13
FT /note="T -> R (in dbSNP:rs7252128)"
FT /id="VAR_059925"
FT VARIANT 209
FT /note="C -> R (in dbSNP:rs1820128)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_059926"
FT CONFLICT 508
FT /note="R -> H (in Ref. 1; BAD18414)"
FT /evidence="ECO:0000305"
FT CONFLICT 631
FT /note="I -> V (in Ref. 2; CAE45968)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 722 AA; 83124 MW; E316D2E12AFB59F9 CRC64;
MMKEVLSTGQ GNTEVIHTGT LQRYQSYHIG DFCFQEIEKE IHDIEFQCQE DERNGHEAPM
TKIKKLTGST DQHDHRHAGN KPIKDQLGSS FYSHLPELHI IQIKGKIGNQ FEKSTSDAPS
VSTSQRISPR PQIHISNNYG NNSPNSSLLP QKQEVYMREK SFQCNESGKA FNCSSLLRKH
QIPHLGDKQY KCDVCGKLFN HKQYLTCHCR CHTGEKPYKC NECGKSFSQV SSLTCHRRLH
TAVKSHKCNE CGKIFGQNSA LVIHKAIHTG EKPYKCNECD KAFNQQSNLA RHRRIHTGEK
PYKCEECDKV FSRKSTLESH KRIHTGEKPY KCKVCDTAFT WNSQLARHKR IHTGEKTYKC
NECGKTFSHK SSLVCHHRLH GGEKSYKCKV CDKAFAWNSH LVRHTRIHSG GKPYKCNECG
KTFGQNSDLL IHKSIHTGEQ PYKYEECEKV FSCGSTLETH KIIHTGEKPY KCKVCDKAFA
CHSYLAKHTR IHSGEKPYKC NECSKTFRLR SYLASHRRVH SGEKPYKCNE CSKTFSQRSY
LHCHRRLHSG EKPYKCNECG KTFSHKPSLV HHRRLHTGEK SYKCTVCDKA FVRNSYLARH
TRIHTAEKPY KCNECGKAFN QQSQLSLHHR IHAGEKLYKC ETCDKVFSRK SHLKRHRRIH
PGKKPYKCKV CDKTFGSDSH LKQHTGLHTG EKPYKCNECG KAFSKQSTLI HHQAVHGVGK
LD
