ZN607_HUMAN
ID ZN607_HUMAN Reviewed; 696 AA.
AC Q96SK3; F5H141; Q6ZMN2; Q6ZMN4; Q96C40;
DT 13-APR-2004, integrated into UniProtKB/Swiss-Prot.
DT 16-JUN-2009, sequence version 3.
DT 03-AUG-2022, entry version 166.
DE RecName: Full=Zinc finger protein 607;
GN Name=ZNF607;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3), AND VARIANTS
RP ALA-2 AND ARG-531.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2), AND VARIANT ARG-531.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q96SK3; Q99750: MDFI; NbExp=4; IntAct=EBI-747175, EBI-724076;
CC Q96SK3; Q5JR59: MTUS2; NbExp=3; IntAct=EBI-747175, EBI-742948;
CC Q96SK3-3; Q7Z699: SPRED1; NbExp=3; IntAct=EBI-25932974, EBI-5235340;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=3;
CC Name=1;
CC IsoId=Q96SK3-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q96SK3-2; Sequence=VSP_037503;
CC Name=3;
CC IsoId=Q96SK3-3; Sequence=VSP_046843;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK131557; BAD18691.1; -; mRNA.
DR EMBL; AK131559; BAD18693.1; -; mRNA.
DR EMBL; AK027708; BAB55313.1; -; mRNA.
DR EMBL; AC093227; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; BC014850; AAH14850.1; -; mRNA.
DR CCDS; CCDS33006.1; -. [Q96SK3-1]
DR CCDS; CCDS54259.1; -. [Q96SK3-3]
DR RefSeq; NP_001166148.1; NM_001172677.1. [Q96SK3-3]
DR RefSeq; NP_116078.4; NM_032689.4. [Q96SK3-1]
DR RefSeq; XP_006723498.1; XM_006723435.3. [Q96SK3-1]
DR RefSeq; XP_006723499.1; XM_006723436.2.
DR AlphaFoldDB; Q96SK3; -.
DR SMR; Q96SK3; -.
DR BioGRID; 124252; 11.
DR IntAct; Q96SK3; 8.
DR MINT; Q96SK3; -.
DR STRING; 9606.ENSP00000347338; -.
DR iPTMnet; Q96SK3; -.
DR PhosphoSitePlus; Q96SK3; -.
DR BioMuta; ZNF607; -.
DR DMDM; 239938814; -.
DR jPOST; Q96SK3; -.
DR MassIVE; Q96SK3; -.
DR MaxQB; Q96SK3; -.
DR PaxDb; Q96SK3; -.
DR PeptideAtlas; Q96SK3; -.
DR PRIDE; Q96SK3; -.
DR ProteomicsDB; 25534; -.
DR ProteomicsDB; 78122; -. [Q96SK3-1]
DR ProteomicsDB; 78123; -. [Q96SK3-2]
DR Antibodypedia; 16401; 90 antibodies from 16 providers.
DR DNASU; 84775; -.
DR Ensembl; ENST00000355202.9; ENSP00000347338.2; ENSG00000198182.13. [Q96SK3-1]
DR Ensembl; ENST00000395835.7; ENSP00000438015.1; ENSG00000198182.13. [Q96SK3-3]
DR GeneID; 84775; -.
DR KEGG; hsa:84775; -.
DR MANE-Select; ENST00000355202.9; ENSP00000347338.2; NM_032689.5; NP_116078.4.
DR UCSC; uc002ohb.3; human. [Q96SK3-1]
DR CTD; 84775; -.
DR GeneCards; ZNF607; -.
DR HGNC; HGNC:28192; ZNF607.
DR HPA; ENSG00000198182; Low tissue specificity.
DR neXtProt; NX_Q96SK3; -.
DR OpenTargets; ENSG00000198182; -.
DR PharmGKB; PA134938252; -.
DR VEuPathDB; HostDB:ENSG00000198182; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000163859; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q96SK3; -.
DR OMA; MACRSIT; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q96SK3; -.
DR TreeFam; TF341817; -.
DR PathwayCommons; Q96SK3; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q96SK3; -.
DR BioGRID-ORCS; 84775; 9 hits in 1089 CRISPR screens.
DR GenomeRNAi; 84775; -.
DR Pharos; Q96SK3; Tdark.
DR PRO; PR:Q96SK3; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q96SK3; protein.
DR Bgee; ENSG00000198182; Expressed in secondary oocyte and 133 other tissues.
DR ExpressionAtlas; Q96SK3; baseline and differential.
DR Genevisible; Q96SK3; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 15.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 19.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 12.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 18.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 20.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..696
FT /note="Zinc finger protein 607"
FT /id="PRO_0000047689"
FT DOMAIN 6..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 114..136
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 142..164
FT /note="C2H2-type 2; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 170..192
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 197..219
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 225..247
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 253..275
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 281..303
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 309..331
FT /note="C2H2-type 8; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 365..387
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 393..415
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 421..443
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 449..471
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 477..499
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 505..527
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 533..555
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 561..583
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 589..611
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 617..639
FT /note="C2H2-type 18"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 645..667
FT /note="C2H2-type 19"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 673..695
FT /note="C2H2-type 20"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..325
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_037503"
FT VAR_SEQ 46
FT /note="Missing (in isoform 3)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_046843"
FT VARIANT 2
FT /note="S -> A (in dbSNP:rs2909097)"
FT /evidence="ECO:0000269|PubMed:14702039"
FT /id="VAR_057974"
FT VARIANT 70
FT /note="R -> H (in dbSNP:rs2385006)"
FT /id="VAR_057975"
FT VARIANT 123
FT /note="F -> L (in dbSNP:rs35735839)"
FT /id="VAR_057976"
FT VARIANT 375
FT /note="S -> T (in dbSNP:rs960689)"
FT /id="VAR_057977"
FT VARIANT 433
FT /note="R -> H (in dbSNP:rs2385006)"
FT /id="VAR_058306"
FT VARIANT 531
FT /note="K -> R (in dbSNP:rs958305)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:15489334"
FT /id="VAR_058307"
FT VARIANT 653
FT /note="A -> P (in dbSNP:rs17856468)"
FT /id="VAR_057978"
FT CONFLICT 653..654
FT /note="AF -> GL (in Ref. 3; AAH14850)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 696 AA; 80507 MW; 62ABBBDA26A3F875 CRC64;
MSYGSITFGD VAIDFSHQEW EYLSLVQKTL YQEVMMENYD NLVSLAGHSV SKPDLITLLE
QGKEPWMIVR EETRGECTDL DSRCEIISDG KMQLYRKHSC VTLHQRIHNG QKPYECKQCQ
KSFSHLTELM VHQTIHTSEE PDQCEKFRKA FSHLTDLRKH QKINAREKPY ECEECGKVFS
YPANLAQHGK VHVEKPYECK ECGEAFRTSR QLTVHHRFHY GEKPYECKEC GKAFSVYGRL
SRHQSIHTGE KPFECNKCGK SFRLKAGLKV HQSIHTGEKP HECKECGKAF RQFSHLVGHK
RIHTGEKPYE CKECGKGFTC RYQLTMHQRI YSGEKHYECK ENGEAFSSGH QLTAPHTFES
VEKPYKCEEC GKAFSVHGRL TRHQGIHSGK KPYECNKCGK SFRLNSSLKI HQNIHTGEKP
YKCKECGKAF SQRAHLAHHN RIHTGYKPFE CKECGKSFRC ASYLVIHERI HTGEKPYVCQ
ECGKGFSYSH KLTIHRRVHT GEKPYECKEC GKAFSVSGQL TQHLSIHSGK KPFECNKCGK
SFRFISVLKA HQNIHSAEKP YECKECGKAF RHATSLIYHD RTHAGEKSYE CKECGETFSH
ASHLIIHERI HTSDKPYECK RCGKAFHCAS YLVRHESVHA DGNPYMCEEC GKAFNSSHEL
SIHHRVHTGE KPFKCNKCRR SFRLRSILEV HQRIHI
