ZN611_HUMAN
ID ZN611_HUMAN Reviewed; 705 AA.
AC Q8N823; B3KRD5; Q69YG9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 24-NOV-2009, sequence version 2.
DT 03-AUG-2022, entry version 165.
DE RecName: Full=Zinc finger protein 611;
GN Name=ZNF611;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), AND VARIANT
RP ILE-252.
RC TISSUE=Testis;
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M.,
RA Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J.,
RA Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S.,
RA Turner R., Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H.,
RA Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K.,
RA Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D.,
RA Hunkapiller M.W., Myers E.W., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RC TISSUE=Testis;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 108-705, AND VARIANT ILE-252.
RC TISSUE=Amygdala;
RX PubMed=17974005; DOI=10.1186/1471-2164-8-399;
RA Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U.,
RA Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D.,
RA Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A.,
RA Wiemann S., Schupp I.;
RT "The full-ORF clone resource of the German cDNA consortium.";
RL BMC Genomics 8:399-399(2007).
RN [6]
RP SUMOYLATION [LARGE SCALE ANALYSIS] AT LYS-173 AND LYS-221, AND
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=28112733; DOI=10.1038/nsmb.3366;
RA Hendriks I.A., Lyon D., Young C., Jensen L.J., Vertegaal A.C.,
RA Nielsen M.L.;
RT "Site-specific mapping of the human SUMO proteome reveals co-modification
RT with phosphorylation.";
RL Nat. Struct. Mol. Biol. 24:325-336(2017).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q8N823-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q8N823-2; Sequence=VSP_038425;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK091389; BAG52347.1; -; mRNA.
DR EMBL; AK097434; BAC05052.1; -; mRNA.
DR EMBL; AC022150; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CH471135; EAW72093.1; -; Genomic_DNA.
DR EMBL; BC136343; AAI36344.1; -; mRNA.
DR EMBL; AL834123; CAH10596.1; -; mRNA.
DR CCDS; CCDS12855.1; -. [Q8N823-1]
DR CCDS; CCDS54312.1; -. [Q8N823-2]
DR RefSeq; NP_001154971.1; NM_001161499.1. [Q8N823-1]
DR RefSeq; NP_001154972.1; NM_001161500.1. [Q8N823-1]
DR RefSeq; NP_001154973.1; NM_001161501.1. [Q8N823-2]
DR RefSeq; NP_112234.3; NM_030972.3. [Q8N823-1]
DR AlphaFoldDB; Q8N823; -.
DR SMR; Q8N823; -.
DR BioGRID; 123606; 10.
DR IntAct; Q8N823; 4.
DR STRING; 9606.ENSP00000437616; -.
DR iPTMnet; Q8N823; -.
DR PhosphoSitePlus; Q8N823; -.
DR BioMuta; ZNF611; -.
DR DMDM; 269849530; -.
DR EPD; Q8N823; -.
DR jPOST; Q8N823; -.
DR MassIVE; Q8N823; -.
DR MaxQB; Q8N823; -.
DR PaxDb; Q8N823; -.
DR PeptideAtlas; Q8N823; -.
DR PRIDE; Q8N823; -.
DR ProteomicsDB; 72367; -. [Q8N823-1]
DR ProteomicsDB; 72368; -. [Q8N823-2]
DR Antibodypedia; 32616; 73 antibodies from 18 providers.
DR DNASU; 81856; -.
DR Ensembl; ENST00000319783.5; ENSP00000322427.1; ENSG00000213020.10. [Q8N823-1]
DR Ensembl; ENST00000453741.6; ENSP00000443505.1; ENSG00000213020.10. [Q8N823-2]
DR Ensembl; ENST00000540744.5; ENSP00000439211.1; ENSG00000213020.10. [Q8N823-1]
DR Ensembl; ENST00000543227.5; ENSP00000437616.1; ENSG00000213020.10. [Q8N823-1]
DR Ensembl; ENST00000595798.5; ENSP00000469376.1; ENSG00000213020.10. [Q8N823-2]
DR Ensembl; ENST00000602162.5; ENSP00000472648.1; ENSG00000213020.10. [Q8N823-2]
DR Ensembl; ENST00000652185.1; ENSP00000498713.1; ENSG00000213020.10. [Q8N823-1]
DR GeneID; 81856; -.
DR KEGG; hsa:81856; -.
DR MANE-Select; ENST00000652185.1; ENSP00000498713.1; NM_001161499.2; NP_001154971.1.
DR UCSC; uc002pzz.4; human. [Q8N823-1]
DR CTD; 81856; -.
DR DisGeNET; 81856; -.
DR GeneCards; ZNF611; -.
DR HGNC; HGNC:28766; ZNF611.
DR HPA; ENSG00000213020; Low tissue specificity.
DR MalaCards; ZNF611; -.
DR neXtProt; NX_Q8N823; -.
DR OpenTargets; ENSG00000213020; -.
DR PharmGKB; PA134988282; -.
DR VEuPathDB; HostDB:ENSG00000213020; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000164431; -.
DR HOGENOM; CLU_002678_44_5_1; -.
DR InParanoid; Q8N823; -.
DR OMA; KHTRIHC; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q8N823; -.
DR TreeFam; TF341892; -.
DR PathwayCommons; Q8N823; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q8N823; -.
DR BioGRID-ORCS; 81856; 5 hits in 1022 CRISPR screens.
DR ChiTaRS; ZNF611; human.
DR GenomeRNAi; 81856; -.
DR Pharos; Q8N823; Tdark.
DR PRO; PR:Q8N823; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q8N823; protein.
DR Bgee; ENSG00000213020; Expressed in buccal mucosa cell and 204 other tissues.
DR ExpressionAtlas; Q8N823; baseline and differential.
DR Genevisible; Q8N823; HS.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 15.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 9.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 13.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 17.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Isopeptide bond; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation;
KW Ubl conjugation; Zinc; Zinc-finger.
FT CHAIN 1..705
FT /note="Zinc finger protein 611"
FT /id="PRO_0000234596"
FT DOMAIN 24..97
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 231..253
FT /note="C2H2-type 1; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 259..281
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 287..309
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 315..337
FT /note="C2H2-type 4; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 343..364
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 370..392
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 398..420
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 426..448
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 454..476
FT /note="C2H2-type 9; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 482..504
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 510..532
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 538..560
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 566..588
FT /note="C2H2-type 13"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 594..616
FT /note="C2H2-type 14"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 622..644
FT /note="C2H2-type 15"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 650..672
FT /note="C2H2-type 16"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 678..700
FT /note="C2H2-type 17"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT CROSSLNK 173
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT CROSSLNK 221
FT /note="Glycyl lysine isopeptide (Lys-Gly) (interchain with
FT G-Cter in SUMO2)"
FT /evidence="ECO:0007744|PubMed:28112733"
FT VAR_SEQ 1..69
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039,
FT ECO:0000303|PubMed:15489334"
FT /id="VSP_038425"
FT VARIANT 234
FT /note="N -> I (in dbSNP:rs3884051)"
FT /id="VAR_060429"
FT VARIANT 252
FT /note="P -> I (requires 2 nucleotide substitutions;
FT dbSNP:rs34846371)"
FT /evidence="ECO:0000269|PubMed:14702039,
FT ECO:0000269|PubMed:17974005"
FT /id="VAR_060722"
FT VARIANT 252
FT /note="P -> L (in dbSNP:rs4085566)"
FT /id="VAR_052876"
FT VARIANT 252
FT /note="P -> T (in dbSNP:rs4085565)"
FT /id="VAR_059927"
FT VARIANT 340
FT /note="E -> G (in dbSNP:rs4087790)"
FT /id="VAR_052877"
FT CONFLICT 123
FT /note="N -> D (in Ref. 1; BAC05052)"
FT /evidence="ECO:0000305"
FT CONFLICT 379
FT /note="F -> S (in Ref. 1; BAC05052)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 705 AA; 81449 MW; F11342304C5C0CA8 CRC64;
MLREEAAQKR KGKEPGMALP QGRLTFRDVA IEFSLAEWKC LNPSQRALYR EVMLENYRNL
EAVDISSKCM MKEVLSTGQG NTEVIHTGTL QRHESHHIGD FCFQEIEKEI HDIEFQCQED
ERNGLEAPMT KIKKLTGSTD QHDHRHAGNK PIKDQLGSSF YSHLPELHIF QIKGEIGNQL
EKSTNDAPSV STFQRISCRP QTQISNNYGN NPLNSSLLPQ KQEVHMREKS FQCNKSGKAF
NCSSLLRKHQ IPHLGDKQYK CDVCGKLFNH EQYLACHDRC HTVEKPYKCK ECGKTFSQES
SLTCHRRLHT GVKRYNCNEC GKIFGQNSAL LIDKAIDTGE NPYKCNECDK AFNQQSQLSH
HRIHTGEKPY KCEECDKVFS RKSTIETHKR IHTGEKPYRC KVCDTAFTWH SQLARHRRIH
TAKKTYKCNE CGKTFSHKSS LVCHHRLHGG EKSYKCKVCD KAFVWSSQLA KHTRIDCGEK
PYKCNECGKT FGQNSDLLIH KSIHTGEQPY KCDECEKVFS RKSSLETHKI GHTGEKPYKC
KVCDKAFACH SYLAKHTRIH SGEKPYKCNE CSKTFSHRSY LVCHHRVHSG EKPYKCNECS
KTFSRRSSLH CHRRLHSGEK PYKCNECGNT FRHCSSLIYH RRLHTGEKSY KCTICDKAFV
RNSLLSRHTR IHTAEKPYKC NECGKAFNQQ SHLSRHHRIH TGEKP
