ZN613_HUMAN
ID ZN613_HUMAN Reviewed; 617 AA.
AC Q6PF04; Q96SS9;
DT 16-MAY-2006, integrated into UniProtKB/Swiss-Prot.
DT 17-OCT-2006, sequence version 2.
DT 03-AUG-2022, entry version 163.
DE RecName: Full=Zinc finger protein 613;
GN Name=ZNF613;
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
RX PubMed=14702039; DOI=10.1038/ng1285;
RA Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H.,
RA Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M.,
RA Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K.,
RA Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T.,
RA Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M.,
RA Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S.,
RA Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H.,
RA Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K.,
RA Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N.,
RA Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y.,
RA Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K.,
RA Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T.,
RA Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T.,
RA Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y.,
RA Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H.,
RA Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y.,
RA Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H.,
RA Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O.,
RA Isogai T., Sugano S.;
RT "Complete sequencing and characterization of 21,243 full-length human
RT cDNAs.";
RL Nat. Genet. 36:40-45(2004).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), AND VARIANT ASN-84.
RC TISSUE=Placenta;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: May be involved in transcriptional regulation.
CC -!- INTERACTION:
CC Q6PF04; Q9BWT7: CARD10; NbExp=3; IntAct=EBI-12062855, EBI-3866279;
CC Q6PF04; Q5TD97: FHL5; NbExp=3; IntAct=EBI-12062855, EBI-750641;
CC Q6PF04; Q6L8G8: KRTAP5-7; NbExp=3; IntAct=EBI-12062855, EBI-11987425;
CC Q6PF04; Q99750: MDFI; NbExp=3; IntAct=EBI-12062855, EBI-724076;
CC Q6PF04; Q5JR59-3: MTUS2; NbExp=3; IntAct=EBI-12062855, EBI-11522433;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=2;
CC Name=1;
CC IsoId=Q6PF04-1; Sequence=Displayed;
CC Name=2;
CC IsoId=Q6PF04-2; Sequence=VSP_018388;
CC -!- SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein
CC family. {ECO:0000305}.
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DR EMBL; AK027565; BAB55201.1; -; mRNA.
DR EMBL; BC057776; AAH57776.1; -; mRNA.
DR CCDS; CCDS12844.1; -. [Q6PF04-2]
DR CCDS; CCDS33089.1; -. [Q6PF04-1]
DR RefSeq; NP_001026891.2; NM_001031721.3. [Q6PF04-1]
DR RefSeq; NP_079116.2; NM_024840.3. [Q6PF04-2]
DR RefSeq; XP_005259326.1; XM_005259269.3. [Q6PF04-1]
DR RefSeq; XP_011525635.1; XM_011527333.2. [Q6PF04-1]
DR RefSeq; XP_016882804.1; XM_017027315.1. [Q6PF04-2]
DR AlphaFoldDB; Q6PF04; -.
DR SMR; Q6PF04; -.
DR BioGRID; 122982; 5.
DR IntAct; Q6PF04; 5.
DR STRING; 9606.ENSP00000293471; -.
DR iPTMnet; Q6PF04; -.
DR PhosphoSitePlus; Q6PF04; -.
DR BioMuta; ZNF613; -.
DR DMDM; 116242862; -.
DR EPD; Q6PF04; -.
DR jPOST; Q6PF04; -.
DR MassIVE; Q6PF04; -.
DR MaxQB; Q6PF04; -.
DR PaxDb; Q6PF04; -.
DR PeptideAtlas; Q6PF04; -.
DR PRIDE; Q6PF04; -.
DR ProteomicsDB; 67093; -. [Q6PF04-1]
DR ProteomicsDB; 67094; -. [Q6PF04-2]
DR Antibodypedia; 19057; 97 antibodies from 16 providers.
DR DNASU; 79898; -.
DR Ensembl; ENST00000293471.11; ENSP00000293471.5; ENSG00000176024.18. [Q6PF04-1]
DR Ensembl; ENST00000391794.8; ENSP00000375671.3; ENSG00000176024.18. [Q6PF04-2]
DR GeneID; 79898; -.
DR KEGG; hsa:79898; -.
DR MANE-Select; ENST00000293471.11; ENSP00000293471.5; NM_001031721.4; NP_001026891.2.
DR UCSC; uc002pxz.3; human. [Q6PF04-1]
DR CTD; 79898; -.
DR DisGeNET; 79898; -.
DR GeneCards; ZNF613; -.
DR HGNC; HGNC:25827; ZNF613.
DR HPA; ENSG00000176024; Tissue enhanced (prostate).
DR neXtProt; NX_Q6PF04; -.
DR OpenTargets; ENSG00000176024; -.
DR PharmGKB; PA134937067; -.
DR VEuPathDB; HostDB:ENSG00000176024; -.
DR eggNOG; KOG1721; Eukaryota.
DR GeneTree; ENSGT00940000162851; -.
DR HOGENOM; CLU_002678_44_0_1; -.
DR InParanoid; Q6PF04; -.
DR OMA; LMDHQRV; -.
DR OrthoDB; 1318335at2759; -.
DR PhylomeDB; Q6PF04; -.
DR TreeFam; TF350804; -.
DR PathwayCommons; Q6PF04; -.
DR Reactome; R-HSA-212436; Generic Transcription Pathway.
DR SignaLink; Q6PF04; -.
DR BioGRID-ORCS; 79898; 10 hits in 1103 CRISPR screens.
DR ChiTaRS; ZNF613; human.
DR GenomeRNAi; 79898; -.
DR Pharos; Q6PF04; Tdark.
DR PRO; PR:Q6PF04; -.
DR Proteomes; UP000005640; Chromosome 19.
DR RNAct; Q6PF04; protein.
DR Bgee; ENSG00000176024; Expressed in ventricular zone and 94 other tissues.
DR ExpressionAtlas; Q6PF04; baseline and differential.
DR Genevisible; Q6PF04; HS.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IBA:GO_Central.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd07765; KRAB_A-box; 1.
DR InterPro; IPR001909; KRAB.
DR InterPro; IPR036051; KRAB_dom_sf.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR Pfam; PF01352; KRAB; 1.
DR Pfam; PF00096; zf-C2H2; 10.
DR SMART; SM00349; KRAB; 1.
DR SMART; SM00355; ZnF_C2H2; 12.
DR SUPFAM; SSF109640; SSF109640; 1.
DR SUPFAM; SSF57667; SSF57667; 7.
DR PROSITE; PS50805; KRAB; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 12.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 12.
PE 1: Evidence at protein level;
KW Alternative splicing; DNA-binding; Metal-binding; Nucleus;
KW Reference proteome; Repeat; Transcription; Transcription regulation; Zinc;
KW Zinc-finger.
FT CHAIN 1..617
FT /note="Zinc finger protein 613"
FT /id="PRO_0000234597"
FT DOMAIN 8..78
FT /note="KRAB"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00119"
FT ZN_FING 204..226
FT /note="C2H2-type 1"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 232..254
FT /note="C2H2-type 2"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 260..282
FT /note="C2H2-type 3"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 288..310
FT /note="C2H2-type 4"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 316..338
FT /note="C2H2-type 5"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 344..366
FT /note="C2H2-type 6"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 372..394
FT /note="C2H2-type 7"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 400..422
FT /note="C2H2-type 8"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 428..450
FT /note="C2H2-type 9"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 456..478
FT /note="C2H2-type 10"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 484..506
FT /note="C2H2-type 11"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT ZN_FING 512..535
FT /note="C2H2-type 12"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00042"
FT VAR_SEQ 1..36
FT /note="Missing (in isoform 2)"
FT /evidence="ECO:0000303|PubMed:14702039"
FT /id="VSP_018388"
FT VARIANT 84
FT /note="D -> N (in dbSNP:rs17854933)"
FT /evidence="ECO:0000269|PubMed:15489334"
FT /id="VAR_028096"
FT VARIANT 93
FT /note="K -> E (in dbSNP:rs8106409)"
FT /id="VAR_028097"
FT VARIANT 135
FT /note="I -> R (in dbSNP:rs16983243)"
FT /id="VAR_028098"
FT VARIANT 163
FT /note="S -> F (in dbSNP:rs33998555)"
FT /id="VAR_057428"
FT VARIANT 611
FT /note="D -> V (in dbSNP:rs16983253)"
FT /id="VAR_057429"
SQ SEQUENCE 617 AA; 70143 MW; 44C6B14BB2060322 CRC64;
MIKSQESLTL EDVAVEFTWE EWQLLGPAQK DLYRDVMLEN YSNLVSVGYQ ASKPDALFKL
EQGEPWTVEN EIHSQICPEI KKVDNHLQMH SQKQRCLKRV EQCHKHNAFG NIIHQRKSDF
PLRQNHDTFD LHGKILKSNL SLVNQNKRYE IKNSVGVNGD GKSFLHAKHE QFHNEMNFPE
GGNSVNTNSQ FIKHQRTQNI DKPHVCTECG KAFLKKSRLI YHQRVHTGEK PHGCSICGKA
FSRKSGLTEH QRNHTGEKPY ECTECDKAFR WKSQLNAHQK IHTGEKSYIC SDCGKGFIKK
SRLINHQRVH TGEKPHGCSL CGKAFSKRSR LTEHQRTHTG EKPYECTECD KAFRWKSQLN
AHQKAHTGEK SYICRDCGKG FIQKGNLIVH QRIHTGEKPY ICNECGKGFI QKGNLLIHRR
THTGEKPYVC NECGKGFSQK TCLISHQRFH TGKTPFVCTE CGKSCSHKSG LINHQRIHTG
EKPYTCSDCG KAFRDKSCLN RHRRTHTGER PYGCSDCGKA FSHLSCLVYH KGMLHAREKC
VGSVKLENPC SESHSLSHTR DLIQDKDSVN MVTLQMPSVA AQTSLTNSAF QAESKVAIVS
QPVARSSVSA DSRICTE
